Characterizing the association between asthma and clinical outcomes in emergency department patients with symptomatic COVID-19

Characterizing the association between asthma and clinical outcomes in emergency department patients with symptomatic COVID-19 | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Characterizing the association between asthma and clinical outcomes in emergency department patients with symptomatic COVID-19 Bachar Al Mazloum, Corrine Hohl, Harriet Richardson, Yingwei Peng, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4714177/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Few studies have investigated the risks of developing intubation and death in patients seen in the ED with COVID-19 and pre-existing asthma. We conducted a retrospective cohort study using data from the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) from March 1st, 2020, to December 31st, 2021. Inclusion criteria were age ≥18 and a positive SARS CoV-2 test. The primary outcome was a composite of intubation or death, and the secondary outcome was severe COVID-19 as defined by the World Health Organization. Multivariable modified Poisson regression was used to assess the association between asthma and outcomes, adjusted for possible confounding. Out of 38,139 patients, 2,826 (7.41%) had asthma, and 17.1% were using inhaled corticosteroids (ICS). The study found no significant evidence suggesting an association between asthma and intubation or death in the hospital (RR: 0.97; 95% CI: 0.86, 1.1). The highest risk group for the primary outcome was patients aged 80+ years (RR: 10.54; 95% CI: 7.01, 15.85), compared to the reference group 18-29 years. Users of ICS agents had a slightly higher risk of the primary outcome compared to non-ICS users (RR: 1.12; 95% CI: 1.01, 1.25). Clinical Trial Registration ClinicalTrials.gov NCT04702945 Health sciences/Diseases/Respiratory tract diseases Health sciences/Diseases/Respiratory tract diseases/Asthma Health sciences/Health care/Public health/Epidemiology Severe acute respiratory syndrome coronavirus 2 COVID-19 asthma emergency department inhaled corticosteroids observational study Full Text Additional Declarations Competing interest reported. During this study, Dr. Rowe was the Scientific Director of the Institute of Circulatory and Respiratory Health (ICRH) at CIHR. The Institute’s mandate includes respiratory health. Dr. Rowe’s research is supported by a Scientific Director’s Grant from CIHR Operating Grant (CIHR SOP#: 168483). Other authors declare that they have no conflict of interest Supplementary Files SupplementarryMaterial.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4714177","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":336758237,"identity":"2bea8a40-7188-4f59-82bd-97dddd318cf1","order_by":0,"name":"Bachar Al Mazloum","email":"","orcid":"","institution":"Queen's University","correspondingAuthor":false,"prefix":"","firstName":"Bachar","middleName":"Al","lastName":"Mazloum","suffix":""},{"id":336758238,"identity":"6ec13ee5-6bec-42dc-9a85-3285f96d5de5","order_by":1,"name":"Corrine Hohl","email":"","orcid":"","institution":"University of British Columbia","correspondingAuthor":false,"prefix":"","firstName":"Corrine","middleName":"","lastName":"Hohl","suffix":""},{"id":336758239,"identity":"73f0264a-85e2-4f6a-9a18-7673aa326870","order_by":2,"name":"Harriet Richardson","email":"","orcid":"","institution":"Queen's University","correspondingAuthor":false,"prefix":"","firstName":"Harriet","middleName":"","lastName":"Richardson","suffix":""},{"id":336758240,"identity":"1271a75c-8cc5-45f8-b9af-272acc434b78","order_by":3,"name":"Yingwei Peng","email":"","orcid":"","institution":"Queen's University","correspondingAuthor":false,"prefix":"","firstName":"Yingwei","middleName":"","lastName":"Peng","suffix":""},{"id":336758241,"identity":"e8d771f5-4f2b-4c2b-a937-6f9dc266d38d","order_by":4,"name":"Brian H Rowe","email":"","orcid":"","institution":"University of Alberta","correspondingAuthor":false,"prefix":"","firstName":"Brian","middleName":"H","lastName":"Rowe","suffix":""},{"id":336758242,"identity":"4ac8174b-19a4-4ba8-aade-f4c803efe04e","order_by":5,"name":"Vlad Latiu","email":"","orcid":"","institution":"Queen's University","correspondingAuthor":false,"prefix":"","firstName":"Vlad","middleName":"","lastName":"Latiu","suffix":""},{"id":336758243,"identity":"8834355f-73d5-4da1-9b65-5cce9566d4b5","order_by":6,"name":"Dryden Chadwick","email":"","orcid":"","institution":"Queen's University","correspondingAuthor":false,"prefix":"","firstName":"Dryden","middleName":"","lastName":"Chadwick","suffix":""},{"id":336758244,"identity":"afbe4398-6dcb-41b7-93a2-cd35f44d97f9","order_by":7,"name":"Kavish Chandra","email":"","orcid":"","institution":"Dalhousie University","correspondingAuthor":false,"prefix":"","firstName":"Kavish","middleName":"","lastName":"Chandra","suffix":""},{"id":336758245,"identity":"6c727cbf-9b40-45f9-bb94-9868ee0eb95a","order_by":8,"name":"Steven Brooks","email":"data:image/png;base64,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","orcid":"","institution":"Queen's University","correspondingAuthor":true,"prefix":"","firstName":"Steven","middleName":"","lastName":"Brooks","suffix":""}],"badges":[],"createdAt":"2024-07-09 19:53:21","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4714177/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4714177/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":64589376,"identity":"46c990e7-689a-44f5-a513-55e5379ef5a4","added_by":"auto","created_at":"2024-09-16 09:00:05","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":388087,"visible":true,"origin":"","legend":"","description":"","filename":"NatureScientificreportsmanuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4714177/v1_covered_54e4331c-63d2-4577-a079-533d05cc6aa6.pdf"},{"id":62058333,"identity":"f8edb833-ca03-47d6-aefc-e2c7d5316993","added_by":"auto","created_at":"2024-08-08 20:44:43","extension":"pdf","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":206260,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementarryMaterial.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4714177/v1/fb55f85982469250061e148a.pdf"}],"financialInterests":"Competing interest reported. 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