Medication administration time: an independent risk predictor for hypotension after induction of general anaesthesia for non-cardiac surgery: a retrospective observational study

Background: Hypotension following induction of general anaesthesia (GAIH) is common, and it's associated with adverse outcomes. Although demographic and dose-related factors have been investigated, it is unknown whether administration time has an effect. Methods: Our analysis included 142 individuals who underwent elective otorhinolaryngologic procedures between March 1, 2017 and August 31, 2017. Under intravenous anaesthesia, patients were intubated using a single lumen endotracheal tube. The occurrence of GAIH, defined as a 30% decline in MAP from baseline, was recorded, and the risk variables for GAIH, including demographical, dose-related, and time-related factors, were investigated. Results: The final analysis includes 123 of the 142 participants that were enrolled in our trial. GAIH occurred 15.45 percent of the time between entering the operating room and intubation, and 55.28 percent of the time between intubation and the commencement of surgery. Propofol's time to peak effect (P propofol ) (less than -0.4 min or more than 0.6 min) was associated with a lower risk of GAIH (OR 0.354, 95 percent CI, 0.142–0.884, p =0.026). Conclusions: Medication administration, especially P propofol , is a risk factor for GAIH. Trial registration Chinese Clinical Trial Registry, registered 04/05/2021 - Retrospectively registered, http://www.chictr.org.cn/edit.aspx?pid=125840&htm=4