Could Bisphenol-A have a role in the etiology of neural tube defects?

Abstract Objective: In this study, we aimed to evaluate BPA levels in the maternal serum and amniotic fluid of patients diagnosed with NTD. In addition, we wanted to investigate the relationship between neurodevelopmental defects, such as neural tube defects (NTD), and BPA levels. Study design: The study consisted of 92 patients between the ages of 18-45 who had an amniocentesis at 15-22 weeks of gestation. The patients were divided into two groups according to the indications of amniocentesis. Maternal serum samples taken during the amniocentesis procedure of all patients were delivered to the biochemistry laboratory. The BPA values between groups were compared. Results: In cases with NTD, amniotic fluid BPA levels and maternal blood BPA levels were significantly higher than the control group. Conclusion: Plastic, which is indispensable for modern life, may negatively affect fetal development in intrauterine life. This study says that high maternal blood BPA may be associated with NTD.