Different brain regions support deliberation during food choice in disordered and healthy eating

Different brain regions support deliberation during food choice in disordered and healthy eating | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Different brain regions support deliberation during food choice in disordered and healthy eating Akram Bakkour, Alexandra Muratore, Eileen Hartnett, Karin Foerde, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7753169/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The brain is wired to drive behavior towards foods that are high in sugar and fat. This natural pattern is reversed in individuals with anorexia nervosa (AN), who prefer low-sugar and low-fat foods to the point of starvation and even death. Here, we aimed to understand how changes in the brain contribute to the pattern of maladaptive food-related decisions in AN. We combined decision-making tasks with computational modeling of behavior and fMRI to examine food and non food-related decisions in individuals with AN and healthy controls (HC). Results from this pre-registered study suggest that patients with AN employ a decision process that relies on sampling and evaluating evidence that is similar to that in healthy individuals, regardless of the type of decision. However, when deliberating about what to eat, while HC engage the hippocampus, individuals with AN engage the striatum in addition to the hippocampus, apparently as sources of evidence in the decision process. These findings suggest that the maladaptive reversal of preferences in AN is related to reliance on different inputs to the process that leads to choice of food, rather than a maladaptive decision process per se . Biological sciences/Neuroscience/Cognitive neuroscience/Decision Health sciences/Diseases/Psychiatric disorders anorexia nervosa decision-making food choice restrictive eating fMRI computational psychiatry Full Text Additional Declarations Yes there is potential conflict of interest. Supplementary Files MuratoreANDMSsupplement.pdf Supplemental Material MuratoreANDMSsupplement.pdf Supplemetary Information Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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