Matrine-chitosan hydrogels for treating subclinical bovine mastitis by intramammary infusion—effect on milk microbiome and metabolites

Matrine-chitosan hydrogels for treating subclinical bovine mastitis by intramammary infusion—effect on milk microbiome and metabolites | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Matrine-chitosan hydrogels for treating subclinical bovine mastitis by intramammary infusion—effect on milk microbiome and metabolites Fuxin Wu, Hua Zhang, Hui Niu, Benhai Xiong, Jinjin Tong, Linshu Jiang This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-26655/v1 This work is licensed under a CC BY 4.0 License Status: Under Revision Version 1 posted 12 You are reading this latest preprint version Abstract Background The metabolic processes of cows undergo significant changes during subclinical mastitis, but their molecular mechanisms have not been clearly elucidated. This study investigated the changes in milk metabolites after intramammary infusion of matrine, a plant alkaloid with anticancer properties, in the form of a chitosan hydrogel into bovine mammary glands with subclinical mastitis. Infusions were continued for seven days, and milk samples were collected on day 1 and day 7 for analysis of the microbiome by 16S rRNA gene sequencing and metabolites by liquid chromatography-mass spectrometry. Results Matrine-chitosan hydrogels (MCHs) significantly decreased the somatic cell count on day 7 and the Simpson index indicated that microbial diversity was significantly lower on day 7 than on day 1. On day 7, the numbers of Aerococcus, Corynebacterium_1 and Staphylococcus were significantly lower, while the abundance of Firmicutes was very significantly decreased. The numbers of Probacteria increased, however. In milk samples, we identified 74 differentially expressed metabolites and the MCH infusion group had the most significantly upregulated metabolites including sphingolipids, glycerophospholipids, flavonoids and fatty acyls. Principal component analysis and the orthogonal partial least squares discriminant test confirmed good separation of the milk metabolites. The identification of active milk metabolic pathways after MCH treatment supported the known antimicrobial and anti-inflammatory properties of matrine that are associated with glycerophospholipid metabolism and the sphingolipid metabolic signaling pathways. Conciusions  These insights into the mechanisms and the corresponding biological responses to matrine demonstrate its potential immunoregulatory activity and emphasize the need for continued investigation. Small Animal Medicine Large Animal Medicine matrine-chitosan hydrogels inflammatory factors microbiome metabolomics subclinical-mastitis dairy cows Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 1. Background The udder microbiota plays an important role in the host-pathogen interactions of the innate and adaptive immune system. This is especially true of pathogens that trigger inflammation that is detrimental to mammary tissue and bovine physiology [ 1 ]. Mastitis is an inflammation of the udder most commonly from bacterial infection, and the pathological changes not only affect milk quality but also quantity [ 2 ]. The increasing demand for animal protein has led to substantial growth in the use of antibiotics in food animal production [ 3 ], which can cause antimicrobial resistance that is a global concern for treating human as well as farm animal diseases. Developing an effective drug for mastitis that is safe for use in food animals and for which no resistance exists in the microbial population would be highly desirable for the worldwide dairy industry. Matrine is a polycyclic alkaloid isolated from the plant, Sophora flavescens that has been used in Chinese traditional medicine because of its anticancer, anti-inflammatory, cardioprotective, and opioid effects [ 4 ]. Previous research [ 5 ] found that matrine inhibited the virulence of Staphylococcus aureus, one of the main pathogens of mastitis. Furthermore, matrine attenuated the lipopolysaccharide-induced immune response by downregulating IL-1 and IL-17 and inhibiting production of the proinflammatory compound, malondialdehyde, reducing inflammation and oxidative stress, and enhancing CCR7 expression [ 6 , 7 ]. Chitosan is a natural polymer produced by acetylation and enzymatic cleavage of chitin, which is the most abundant animal polysaccharide in nature.[ 8 ]. The applications for chitosan have continued to increase because of the abundance of its source, its biocompatibility and ease of chemical modification. Studies have also shown that chitosan has anti-inflammatory, antimicrobial, cholesterol-lowering, immunomodulatory, and antitumor properties [ 5 ]. Chitosan can be beneficial at the cellular or molecular level [ 9 ], by reducing intracellular material leakage and triggering an antimicrobial response to enhance the therapeutic effects of mastitis treatment. Chitosan can be formulated to be injectable at room temperature but change into a biodegradable hydrogel at body temperature [ 10 ]. It has been used in drug formulations and delivery vehicles for decades; however, the influence of matrine and chitosan on the udders of dairy cows has received little research attention. Therefore, it is worthwhile to explore the effectiveness of intramammary infusion of matrine-loaded chitosan hydrogels (MCHs) on the udders of dairy cows with mastitis in terms of positively changing the microbial population and metabolic profile of milk. We hypothesized that intramammary injection of MCHs would favor the growth of beneficial microorganisms and cause a shift in the milk microbiota in normal udder quarters. DNA sequencing has become routine for many labs and the advanced software and bioinformatics databases available have created great opportunities for studying pathogenic mechanisms [ 11 , 12 ]. By understanding the host responses to microbial attack, we hope to be able to identify the most effective targets for antimicrobial intervention, to develop new treatments for bovine mastitis and to find sensitive biomarkers for early detection and diagnosis. Metabolomics can also be used for quantitative measurement of the metabolic state of milk, including the biomarkers of lactation [ 13 ], the variation in metabolites associated with mastitis[ 14 ], and differences in metabolism after antibacterial therapy [ 15 ]. Little is known about the changes in milk metabolites in response to MCH treatment of mastitis, and one of the goals of this study was to obtain detailed information on the effect of matrine delivery by chitosan hydrogel injection into bovine mammary glands on milk microbiota and metabolites. We investigated the effects MCHs on subclinical-mastitis and the relationship between milk microbiota diversity and metabolite profiles, to probe the mechanisms of the antibacterial benefits of matrine and chitosan for mastitis, and to provide new knowledge for the development of novel, safe and effective prophylactic and therapeutic compounds for dairy cow operations. 2. Results 2.1. Somatic cell counts in milk Matrine-chitosan hydrogels significantly decreased the somatic cell count on day 7 compared to day 1 (p < 0. 05) (Fig. 1 ). 2.2. Diversity and relative numbers of milk microbiota A total of 1,117,565 high-quality sequences from twelve samples passed quality control and could be used for testing. The sequences averaged 308 bp, and there was greater than ninety-nine percent depth coverage; therefore, the amount of data was sufficient to show differences in all bacterial species. The α-diversity indices of the microbiota are shown in table 1. Although ACE showed a tendency to decrease, no different was observed in the Chao indices, which were all representative of bacterial community richness. Moreover, the Simpson index showed that the bacterial diversity at day 7 was significantly lower than at day 1 (p༜0.05), and there was an overall tendency to decrease (p = 0.06), but this is variable and depends on if the calculations are based on abundance or biomass. No significant differences were seen among the groups for the other α-diversities. Principal component analysis (PCA) on the microbial populations present on day 1 vs day 7 showed clear differences, and the weighted UniFrac values were also determined (Fig. 2 ). Principal coordinates one and two were found to account for 51.76 and 26.2% of total variance, confirming that the milk microbiome after seven days of MCH infusion was remarkably distinct from that on day one. The taxonomic changes in milk samples from day 1 to day 7 were determined. Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes were the three predominant phyla (Fig. 4 A). The abundance of Firmicutes was extremely significantly decreased on day 7 (p = 0.01), whereas the numbers of Proteobacteria increased (p = 0.01) (Fig. 3 A, B). Taxa with a relative abundance of one percent in at least one sample were identified, and the ten most abundant genera are presented (Fig. 3 C, D). On day 7, there was a significantly lower abundance of Aerococcus (p = 0.01), Corynebacterium_1 (p = 0.08) and Staphylococcus (p = 0.03). In contrast, the relative abundances of Pseudomonas (p = 0.01) and Ralstonia (p = 0.02) were significantly increased. 2.3. Identification and comparison of milk metabolites A non-targeted metabolome method was used to evaluate milk metabolites after MCH treatment. Reproducible metabolite data profiles (1001) were obtained and differences between day 1 and day 7 were characterized using VIP metrics from OPLS-DA. Seventy-four milk metabolite signals were obtained that were significantly different between MCH-treated and untreated cows (VIP > 1 and p < 0.05) (table 2). They consisted mainly of sphingolipids, oxanes, glycerophospholipids, flavonoids and fatty acyls. Milk from animals receiving MCHs for seven days had higher levels of steroids and steroid derivatives, prenol lipids, oxanes, macrolides and analogues, hydroxy acids and derivatives, carboxylic acids and derivatives and Benzene and substituted derivatives than milk on day 1. PCA and OPLS-DA were employed to evaluate the differences in metabolomes. The PCA scores showed clear differences between day 1 and day 7 milk samples (Fig. 4 A). Principal components one and two were found to account for 31.70% and 16.10% of the variation. The variables for assessing OPLS-DA model quality are shown in validation plots (Fig. 4 B). The Q2 value of the OPLS-DA model was 0.939, and the R2Y value was 0.963. Q2 represents the model’s prediction ability and the closer these 3 indicators are to 1, the more stable and reliable it is. Q2 > 0.5 indicates that the model’s prediction ability is good, while Q2 < 0.5 indicates poor predictability. The OPLS-DA data confirmed that the two groups had significantly different types and levels of metabolites (Fig. 4 C). OPLS-DA model integrity is shown by validation plots. The day 7 metabolite profiles were significantly different from those of day 1 indicating that the PCA and OPLS-DA results were valid for assessing variations in milk metabolomes between the two days. 2.4. Differences in metabolites resulting from changes in metabolic pathways Comparison of metabolism via changes in pathway activation from MCH treatment on day 1 to 7 was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) for determining enrichment of pathways involved in metabolite production (table 3; Fig. 5 ). Enrichment analysis showed that sphingolipid metabolism, the sphingolipid signaling pathway, glycerophospholipid metabolism and ABC transporters, were significantly affected by MCH injection. Pathway topology analysis (Fig. 6 ) (p < 0.05) revealed 8 key pathways enriched between days 1 and 7. They included sphingolipid, phenylalanine, glycerophospholipid, and starch and sucrose metabolism, synthesis of phenylalanine, tyrosine and tryptophan and linoleic acid metabolism. 3. Discussion The results of this study revealed that MCHs markedly decreased somatic cell count after 7 days of treatment. Although we did not observe any changes in bacterial community richness by the Chao indices, the Simpson index showed a significant decrease in the bacterial diversity. In particular, on day 7, the relative abundance of Firmicutes was significantly decreased, and that of Proteobacteria was significantly increased compared to levels on day 1. It has been reported that the richness and diversity of the milk microbiome reflects the health of the cows and functional performance of the organs [ 16 – 18 ]. Antibacterials are commonly used to treat bovine mastitis, but their efficacy is unclear [ 19 ]. That is why we chose to test the plant-derived compound, matrine, as an intramammary treatment loaded into chitosan hydrogels to see if it would alter the milk microbiota and improve mammary gland function. Measurement of the number of somatic cells in milk is an internationally recognized test for the detection of mastitis. A SCC of more than 200,000 per ml is considered to be evidence of disease[ 20 ]. Recent investigations have shown that the milk microbiota of dairy cows are usually closely associated with the SCC [ 21 , 22 ]. This suggests that modulation of the udder ecosystem through the microbiota could help to maintain homeostasis and enhance the mammary gland’s defense mechanism [ 23 , 24 ]Consistent with these reports, we observed that the udder SCC was significantly increased by in mastitis by common pathogens like Staphylococcus, but was markedly decreased after perfusion of the udder with matrine-chitosan hydrogel. This is in line with previous studies showing that chitosan hydrogels decreased the SCC in milk from dairy cows[ 25 ]. The therapeutic synergy achieved by loading the chitosan hydrogel with matrine suggests potential application in mastitis protection and treatment. The mechanism by which the milk microbiota influences inflammatory and immune responses to decrease the SCC still needs further investigation. The next generation of high-throughput DNA sequencing methods together with updated bioinformatics software is now being used for the in-depth assessment of microbial communities to elucidate how bacterial activity and metabolites affect human and animal health [ 26 ]. We found that the microbial diversity in milk was dramatically decreased after one week of intramammary infusions of matrine-chitosan hydrogels. The relative abundance of Proteobacteria was significantly increased, while Staphylococcus numbers decreased significantly. Staphylococci are internationally recognized as one of the most prevalent mastitis pathogens, accounting for about 70% of the cases [ 2 ].. Moreover, it has been reported that Proteobacteria are significantly more abundant in healthy cows than those with mastitis[ 2 ]. Previous studies also showed that the numbers of Proteobacteria after non-antibiotic hydrogel treatment increased significantly [ 27 ], indicating that hydrogel therapy can effectively return the milk microbial environment to normal diversity and defend against disease. Our investigation provides mechanistic insights into how the microbiota respond to MCH may help in the development of novel prophylactic and therapeutic products as alternatives to antibiotics in dairy cows. Our data are also important for understanding how the regulation of biosynthesis by milk microbiota influences udder health and defense against mastitis. The milk microbiota are usually closely associated with the SCC [ 21 , 22 ]. suggesting that the udder microbiota plays an important part in modulation of the ecosystem and maintenance of homeostasis to resist mammary gland infections [ 23 , 24 ] Metabolomics is a comparatively new research method that has been widely used in the detection of mastitis in recent years due to its more comprehensive test results. Previous studies suggested that metabolomics could provide a more complete understanding of an animal’s physiology and biochemistry .[ 28 ]. The metabolomics data from this study highlight the potential function of matrine-chitosan hydrogels in modulating the metabolite levels, which were found to be enriched in sphingolipid metabolic pathways, phenylalanine, glycerophospholipid, and starch and sucrose metabolism. A previous report suggested that sphingolipid metabolites acted as signaling molecules to regulate a diverse group of cellular processes, particularly those related to immunity, inflammation and inflammatory disorders .[ 29 ]. We speculate that this activity might be associated with the decrease in SCC caused by matrine-chitosan hydrogel injection. The metabolic differences we observed gave us a further insight into how MCH affects metabolite levels before and after mastitis treatment, and showed that alterations in the milk metabolome could be used to reveal the therapeutic mechanism of matrine for mastitis treatment and in the recovery of milk production in dairy cows. We found significant changes in concentration of a number of sphingolipids, glycerolipids, fatty acyls, glycerophospholipids, and organo-oxygen compounds that significantly differed from day 1 to day 7. Sphingolipids are major components of cell membranes and are considered to be widely involved in important processes such as cell aging and apoptosis .[ 30 ]. Glycerolipids [ 30 ] and fatty acyls [ 32 ] are both important components of cell membranes. Previous research found that bacterial invasion can induce inflammatory reactions and cause oxidative damage during the development of the breast [ 33 ], accompanied by apoptosis .[ 34 , 35 ]. The reduction in sphingolipids, glycerolipids, and fatty acyls seen in this study indicates that apoptosis caused by inflammatory reactions may have been weakened. The decrease of organooxygen compounds suggests that the oxidative damage caused by inflammatory reactions may also have been reduced. The metabolites were enriched in sphingolipid and glycerophospholipid metabolism[ 36 ], which are both related to apoptosis pathways.[ 37 , 38 ]. Therefore, we conclude that MCHs can inhibit apoptosis by blocking oxidative damage, thereby reducing inflammatory changes to the udder. It is worth noting that L-phenylalanine is involved in many pathways that are significantly changed in this study (table 3). L-phenylalanine is an essential amino acid and a precursor for the synthesis of antiviral and anticancer drugs as well as new sweeteners. It can also be a marker of inflammatory reactions and affect the body's immune response [ 33 ]. Here, the content of L-phenylalanine was significantly increased on day 7, which means that the immune defenses in the mammary gland may have been effectively improved. Previous study [ 35 ] found that tryptophan and phenylalanine are used in the body to synthesize serotonin, L-DOPA derivatives and 5, 6, 7, 8-tetrahydrobiopterin (BH4), which compounds can affect the severity of inflammation. In the study of Smith ,[ 39 ], tyrosine and phenylalanine participated in the regulation of TLR4 signaling pathways, thereby influencing the degree of inflammation. Phenylalanine also is part of the glycolytic and liposynthetic pathways.[ 40 , 41 ]. It has been reported that phenylalanine deficiency can severely affect protein metabolism in the breast and compromise the health of the organ.[ 42 ]. Phenylalanine is an essential amino acid in milk and is also the precursor of tyrosine, which is one of the main amino acids in milk.[ 43 ]. We know that untreated bovine mastitis results in reduced milk fat and milk protein content; therefore, the increase in L-phenylalanine by MCH injection could be effective in restoring normal milk production during lactation. The milk metabolites produced by MCH injection were found to have an intimate relationship with sphingolipid and glycerophospholipid metabolism. A previous study suggested that the sphingolipid metabolic pathways participate in a variety of immune-related signal transductions, inflammation and inflammatory disorders [ 29 ]. The sphingolipid metabolism-related pathways have many functions, such as regulating cell adhesion and cellular immunity, activating cancer repressors, regulating apoptosis, and modulating immune function and the inflammatory response [ 29 ] We speculate that this activity might be associated with the decrease in SCC caused by MCH injection. Furthermore, Cowart et al. [ 44 ] showed that an imbalance in the pathway for sphingolipid metabolism can cause ketosis, mastitis, and metritis in cows. It has been proved that sphingolipid metabolites, especially ceramide and sphingosine-1-phosphate, can regulate a variety of biochemical processes important in immune, inflammation and inflammatory diseases[ 29 ]. In the present study, we found that MCHs could significantly regulate the sphingolipid metabolism-related pathways to improve inflammation; thus, it is reasonable to believe that MCHs could effectively treat bovine mastitis. Despite the documented health-promoting properties of matrine and chitosan, scientific evidence for the efficacy of MCHs in dairy cows is limited. Our study affords many useful insights, but the effect of MCHs on immune regulation still requires further study. Another limitation relates to the mechanistic links involved in the observed significant changes in the microbiota and biomarker metabolites as a result of MCH injection that will need further exploration to be clearly understood. Previous studies suggested that the antimicrobial activity of chitosan can stimulate the innate immune response and hasten the involution process of the mammary gland[ 25 ]. It is not known whether matrine-chitosan complexes could be used in the circulation to regulate the immune system and inhibit inflammation, but our data indicate that future research in this area is strongly warranted. 4. Conclusions Our data indicate that matrine-chitosan hydrogels significantly decrease the somatic cell counts and affect the structures of bacterial communities in the udder, especially the relative abundances of Corynebacterium_1, Aerococcus and Staphylococcus . These findings show significant changes in metabolites and metabolic pathways as a result of intramammary MCH infusion, and some of the resulting 74 milk metabolites may be used as indicators of the response to MCH treatment. The results from the milk metabolic pathway analysis are promising for the investigation of matrine-chitosan’s antimicrobial and anti-inflammatory properties that are closely associated with sphingolipid and glycerophospholipid metabolism. These insights into the complex mechanisms and corresponding biological responses highlight the beneficial action of matrine-chitosan hydrogels and justify continued investigations to identify the immunoregulatory mechanisms for treatment of mastitis dairy cows. 5. Methods 5.1. Preparation of matrine-loaded chitosan hydrogels Matrine (98% purity) was purchased from Sigma-Aldrich Corp., St. Louis, MO, USA, and chitosan was purchased from Shanghai Sunny Biotech Co., Ltd., China. All solutions were prepared with nonpyrogenic products and materials under aseptic conditions in a laminar flow hood. The procedures were similar to those of Lanctôt et al. [ 25 ]. Matrine (0.05 g) and 4 g of chitosan were added to 95 mL of deionized water and heated at 37 °C until the chitosan dissolved to obtain the matrine-loaded chitosan complexes. Ten ml of matrine-chitosan and 5 ml of 4% hydroxyethyl cellulose (2:1 ratio) were put into disposable plastic dishes (60 mm diameter) and mixed thoroughly. The water used was nonpyrogenic with < 0.005 endotoxin units/mL (Lonza, Walkersville, MD). For intramammary infusion, plastic syringes were filled with the 10 ml of MCH, sealed with a cap, and stored at room temperature. 5.2. Animals and experimental design Animals selected in this study were provided by the Beijing Sunlow Livestock Dairy Farming Center (Beijing, China), our animal protocols were reviewed and accepted by the Animal Care Committee of Beijing University of Agriculture in concordance with the guidelines for the use of bovines in research studies of the SSTCC (The State Science and Technology Commission of the P.R. of China, 2017). The dairy farm owner was consent to collect samples from cows for the presnet study. Samplings of untreated milk (n = 580) were received from commercial dairies in Beijing from June to August 2019 with the California mastitis rapid detection reagent (CMT). Six mid-lactation cows with high somatic cell counts (SCC, average 250,000 cells/ml) indicative of subclinical-mastitis were selected according to their milk yield and parity. There were few initial differences in milk yield (27.2 ± 1.8 kg/d), DIM (114.6 ± 7.5 d), parity (2.6 ± 0.4), or body weight (BW; 670 ± 24 kg). The cows were fed a standard basal diet (table 4), had free access to water and were kept in a tie-stall barn. They received daily intramammary infusions of MCHs after each milking, twice daily, (7 AM and 7 PM) for 7 days. Milk samples were collected on the first day (D 1) and the last injection day (D 7) and totaled 15 ml per animal, with about equal volumes from each lactating udder quarter. Somatic cell counts were determined using an automatic cell counter (DeLaval International AB, Tumba, Sweden), and the remaining milk was stored in liquid nitrogen for later analysis. After the period of experimental, all dairy cows were back to the herd of cows after the veterinary examination and ensure they were healthy. 5.3. Bacterial DNA isolated, 16S rRNA genes amplified and sequenced Bacterial DNA was isolated from milk using a Power Soil DNA isolation kit (Qiagen, U.K.) as previously stated by Tong et al.[ 14 ]. In brief, the DNA concentration and 260/280 ratio were measured with a NanoDrop 1000 spectrophotometer (Nanodrop Technologies, U.S.), and integrity was visualized by running aliquots on an agarose gel. The V1-V2 region of the 16S rRNA gene was PCR-amplified by (GeneAmp 9700, ABI, U.S.) using forward (5'-CGTATCGCCT-CCCTCGCGCCATCAG-3') and reverse (5'-CTA-TGCGCCTTGCCAGCCCGCTCAG-3') primers that incorporated adaptors and barcodes [ 14 , 45 ]. Amplicons of about 450 bp were selected and combined in equal concentrations [ 46 ], then electrophoresed and extracted from the gel with GeneJET (ThermoFisher, Waltham, MA, United States). Paired-end libraries were prepared by Majorbio Bio-Pharm (Shanghai, China). Bacterial ribosomal RNA genes were sequenced with Illumina HiSeq (Illumina, U.S.) for paired-end reads of three hundred base pairs. All raw sequence data were uploaded to NCBI (#SRP254162). 5.4. Analytical bioinformatics of milk microbiotas Analyses were conducted with FLASH version 1.2.11 and quantitative insights into microbial ecology (QIIME) version 1.9.1. These programs gave data similar to that published by Tong et al. [ 14 ]. Sequences were assigned to taxa by BLASTing the ribosomal database project (RDP) dbase using a 97% identity cut-off. Operational taxonomic units (OTUs) were normalized to relative abundance and bacterial composition was determined by Majorbio I-Sanger. Within-sample diversity (α-diversity) was measured as bacterial community enrichment (ACE and Chao indices) and diversity (Shannon and Simpson indices) that were measured in a stochastic subset of the OTUs. Between-sample microbial diversity (β-diversity) was determined by phylogenetically-based weighted UniFrac distances [ 47 ]. A more detailed picture of the diversity of the most abundant evolutionary clades in the bovine microbiota was obtained by filtering the OTUs to yield those with a relative abundance of ≥ 1% for at least one sample. 5.5. Milk metabolome determination Milk samples were assessed by Majorbio Bio-Pharm using the LC-MS AB Sciex Triple TOF 5600TM (AB SCIEX, U.S.) according to published procedures [ 14 ] The liquid chromatography conditions were similar to those of a previous study [ 48 ]. Quality controls were run by combining milk samples and injecting them periodically during experimental measurements. The results were analyzed with XCMS (ver. 3.4.4). The retention times, MZ, observations and peak intensities were normalized with Excel. The differentially expressed metabolites were analyzed with the public database ( https://metlin.scripps.edu/ ) on the Majorbio I-Sanger platform ( www.i-sanger.com ) and the KEGG pathway software for differential metabolite profiles ( www.metaboanalyst.ca/ ). 5.6. Multivariate statistics Comparisons were validated by Student’s t and p < 0.05 was defined as significant. Hierarchical clustering was conducted using the Bray-Curtis similarity index and the unweighted pair-group method with arithmetic averages. The SPSS software v.21.0 (IBM, Armonk, NY) was used. The α-diversity indices are given as mean ± SD. A p < 0.05 was considered statistically significant, and a p < 0.10 suggested a trend. Principal component analysis and orthogonal partial least-squares-discriminant analysis (OPLS-DA) were carried out to show the metabolism changes among the experimental groups after mean centering and unit variance scaling. Parameters with variable importance in the projection (VIP) values > 1.0 were allowed for group discriminant testing. Our OPLS-DA model was confirmed by 7-fold permutation testing. Significantly different metabolites among groups were assessed and identified by Wilcoxon rank-sum tests. Abbreviations MCHs: Matrine-chitosan hydrogels; PCA:Principal component analysis; OPLS-DA:Orthogonal partial least squares discriminant analysis; KEGG:Kyoto Encyclopedia of Genes and Genomes; M: metabolism; HD: human diseases; EIP: environmental information processing; OS: organismal systems; GIP: genetic information processing; SCC: somatic cell counts; CMT: California mastitis rapid detection reagent; RDP:Ribosomal database project; OTUs: Operational taxonomic units Declarations Acknowledgements The authors thank the dairy barn staff for taking care of the cows, especially Kangkang Chu for providing technical assistance. The authors are grateful to Dandan He, from Shanghai Majorbio Bio-pharm Technology Co.,Ltd, for her assistant of the multivariate statistics analysis. Authors' contributions JJT, FXW and LSJ developed hypothesis, conceived the project and responsible for all data, figures and text. JJT, HZ, HN and FXW performed the experiments. FXW and HZ conducted data analysis. JJT and FXW wrote the manuscript. JJT, HZ, LSJ and BHX revised the paper. All authors carefully read the manuscript and agree to be held accountable for all aspects of the work. Funding This study was funded by the Project of the National Natural Science Foundation of China (Grant Nos. 31802091, 31702302 and 31772629) and the National Key Research and Development Plan (2016YFD0700205, 2016YFD0700201, and 2017YFD0701604). Jinjin Tong also thanks the China Postdoctoral Science Foundation and the Beijing Postdoctoral Science Foundation. Linshu Jiang thanks for the Beijing million Talents Project. Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Ethics approval and consent to participate The animal protocols were reviewed and accepted by the Animal Care Committee of Beijing University of Agriculture in concordance with the guidelines for the use of bovines in research studies of the SSTCC (The State Science and Technology Commission of the P.R. of China, 2017). Consent for publication Not Applicable. Conflicts of Interest The authors declare no conflicts of interest regarding this work Author details References Derakhshani H, Plaizier JC, De Buck J, Barkema HW, Khafipour E: Association of bovine major histocompatibility complex ( BoLA ) gene polymorphism with colostrum and milk microbiota of dairy cows during the first week of lactation . MICROBIOME 2018, 6 (1):203. Gao J, Barkema HW, Zhang L, Liu G, Deng Z, Cai L, Shan R, Zhang S, Zou J, Kastelic JP, et al. 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J DAIRY SCI. 2014;97(7):4208–15. Li Y, Hu X, Shuang Y, Zhou J, Lei Q, Sun X, Fan M, Xu S, Muha C, Zhang M. Comparison Between the Fecal Bacterial Microbiota of Healthy and Diarrheic Captive Musk Deer. FRONT MICROBIOL. 2018;9:300. Lozupone C, Knight R. UniFrac: a New Phylogenetic Method for Comparing Microbial Communities. Applied Environmental Microbiology. 2006;71(12):8228–35. Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T, Xie Z, Chu X, Yang J, Wang H, et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression. CELL RES. 2019;29(10):787–803. Tables Table 1. Alpha diversity indices for milk microbiota Item D 1 D 7 p values ACE 1769.86±189.07 1211.79±196.29 0.08 Chao 1675.43±201.72 1176.47±196.24 0.11 Simpson 0.47±0.09 0.19±0.07 0.05* Shannon 3.35±0.52 1.92±0.36 0.06 Coverage 0.99±0.01 0.99±0.02 0.57 Table 2. Milk metabolites on day 1 compared to day 7 after MCH treatment Metabolite M/Z Retention time Mass Error VIP FC(d1/d7) P value Tendency Steroids and steroid derivatives 12b-Hydroxy-5b-cholanoic acid 418.35 9.43 1.12 4.42 0.48 0.01 ↑ Pregnanetriolone 349.24 8.8 -0.06 1.79 0.43 0.026 ↑ Aginoside progenin 814.46 2.51 -2.8 1.02 0.04 ＜0.01 ↑ Sphingolipids SM(d18:0/24:1(15Z)) 859.7 13.36 5.06 1.58 3208275862 ＜0.01 ↓ SM(d18:1/23:0) 845.68 12.95 5.27 2.26 11748.6 ＜0.01 ↓ SM(d18:1/22:1(13Z)) 829.65 11.92 4.59 1.72 369.77 ＜0.01 ↓ SM(d18:0/22:1(13Z)) 831.66 12.73 4.91 4.9 212.45 ＜0.01 ↓ Glucosylceramide (d18:1/16:0) 744.57 11 3.44 1.89 34.01 ＜0.01 ↓ Galactosylceramide (d18:1/14:0) 706.51 10.5 3.07 1.29 27.94 ＜0.01 ↓ Glucosylceramide (d18:1/25:0) 790.69 14.01 -0.89 3.78 21.09 ＜0.01 ↓ stearoyl sphingomyelin 775.6 11.48 4.77 1.32 19.61 ＜0.01 ↓ N-hexadecanoylsphinganine-1-phosphocholine 749.58 11.16 2.57 2.76 16.13 ＜0.01 ↓ Galabiosylceramide (d18:1/16:0) 906.62 10.86 5.8 1.9 9.04 ＜0.01 ↓ SM(d18:0/14:0) 721.55 10.62 3.35 2.94 7.99 ＜0.01 ↓ SM(d18:0/16:1(9Z)) 747.57 10.92 4.52 6.89 3.62 ＜0.01 ↓ N-Glycoloylganglioside GM2 708.61 12.75 -0.87 9.56 2.38 ＜0.01 ↓ SM(d18:1/14:0) 719.54 10.42 3.7 5.12 2.34 ＜0.01 ↓ Araliacerebroside 776.55 10.75 -6.85 1.95 1.49 ＜0.01 ↓ Ganglioside GM1 (d18:1/18:1(11Z)) 772.43 4.33 -7.63 1 0.28 0.02 ↑ nLc6Cer 696.82 3.25 -1.78 2.36 0.09 ＜0.01 ↑ Prenol lipids Hoduloside VI 819.43 2.96 -3.62 1.42 0.05 0.01 ↑ Oxanes D-1,5-Anhydrofructose 325.11 0.78 -0.78 1.1 0.78 ＜0.01 ↑ Organooxygen compounds 3,4,5-trihydroxy-6-(2-hydroxyethoxy)oxane-2-carboxylic acid 475.13 0.7 -1.46 1.13 2.62 ＜0.01 ↓ N6-Galacturonyl-L-lysine 357.11 2.4 8.9 2.54 1.56 0.02 ↓ Lactulose 365.11 0.62 1.53 6.7 0.56 ＜0.01 ↑ Macrolides and analogues Pectenotoxin 7 909.37 2.45 -1.88 1.95 0.1 ＜0.01 ↑ 31-O-Demethyltacrolimus 810.44 0.75 -1.37 1.15 0.03 ＜0.01 ↑ Indoles and derivatives Indole-3-carboxilic acid-O-sulphate 240 2.27 -1 3.13 1.74 ＜0.01 ↓ Hydroxy acids and derivatives 2-Hydroxy-3-methoxyestrone 442.35 9.08 1.05 2.9 0.43 0.01 ↑ Glycerophospholipids PE(15:0/22:0) 806.6 11.84 5.06 2.5 48.31 ＜0.01 ↓ PE(14:0/22:0) 792.58 11.45 8.49 1.14 15.03 ＜0.01 ↓ PS(DiMe(11,3)/MonoMe(11,5)) 880.54 12.16 2.74 1.21 8.01 ＜0.01 ↓ PE(15:0/24:1(15Z)) 832.61 11.77 5.01 4.77 6.11 ＜0.01 ↓ lysoPC(6:0) 400.17 3.01 -1.21 2.04 5.51 ＜0.01 ↓ PE(16:0/16:0) 736.52 10.42 2.96 2.16 2.26 ＜0.01 ↓ PS(18:0/18:1(9Z)) 810.53 11.5 5.99 2.68 2.12 ＜0.01 ↓ PE(18:2(9Z,12Z)/18:1(11Z)) 786.53 12.04 4.76 7.92 1.99 ＜0.01 ↓ PE(15:0/16:0) 722.5 10.33 5.04 3.2 1.85 ＜0.01 ↓ PE(15:0/14:0) 694.47 9.94 3.99 1.33 1.72 ＜0.01 ↓ PE(15:0/22:1(13Z)) 804.58 11.24 5.01 4 1.67 ＜0.01 ↓ PS(16:0/18:0) 784.52 11.45 7.51 3.58 1.63 ＜0.01 ↓ LysoPE(0:0/18:2(9Z,12Z)) 476.28 7.75 -0.17 1.66 1.53 0.05 ↓ PE(18:1(9Z)/16:0) 718.54 11.44 0.48 1.83 1.5 0.03 ↓ PE(15:0/20:2(11Z,14Z)) 774.53 10.37 4.68 1.03 1.39 0.02 ↓ LysoPE(16:0/0:0) 452.28 8.32 0.26 1.84 1.36 0.01 ↓ PS(15:0/24:1(15Z)) 830.6 11.21 4.84 1.71 1.3 0.02 ↓ LysoPC(18:1(9Z)) 566.35 8.31 0.06 3.94 0.68 0.01 ↑ LysoPC(18:2(9Z,12Z)) 564.33 7.79 -1.16 5.06 0.56 0.01 ↑ LysoPC(16:1(9Z)/0:0) 538.32 7.58 1.76 1.12 0.55 0.02 ↑ LysoPE(20:3(11Z,14Z,17Z)/0:0) 502.29 8.11 0.14 1.65 0.5 0.02 ↑ PC(18:2(9Z,12Z)/P-18:0) 814.6 11.07 4.43 1.18 0.47 0.01 ↑ LysoPE(20:4(5Z,8Z,11Z,14Z)/0:0) 500.28 7.8 -0.15 3.45 0.41 ＜0.01 ↑ LysoPE(18:2(9Z,12Z)/0:0) 478.29 7.77 2 2.75 0.35 ＜0.01 ↑ LysoPC(18:1(11Z)) 522.36 8.2 0.69 4.22 0.31 ＜0.01 ↑ LysoPE(0:0/22:5(7Z,10Z,13Z,16Z,19Z)) 562.27 5.39 -0.86 1.06 0.3 ＜0.01 ↑ 1-Linoleoylglycerophosphocholine 520.34 7.69 0.61 4.27 0.17 0.01 ↑ 1-(8Z,11Z,14Z-eicosatrienoyl)-glycero-3-phosphate 502.29 7.7 -0.01 1.27 0.14 ＜0.01 ↑ LysoPC(P-18:0) 552.37 8.59 0.37 1.31 0.09 ＜0.01 ↑ TG(16:1(9Z)/16:1(9Z)/16:1(9Z)) 845.68 13.12 -9.94 3.56 1607.82 ＜0.01 ↓ MG(0:0/16:0/0:0) 365.25 8.94 -0.54 3.43 0.53 0.027 ↑ Flavonoids Menthoside 723.2 0.7 4.79 4.57 2.69 ＜0.01 ↓ Isoscoparin 2''-(6-(E)-ferulylglucoside) 781.2 0.84 -0.3 2.37 1.31 0.02 ↓ Kaempferol 3-(2''-rhamnosylgalactoside) 7-rhamnoside 777.16 0.7 -1.93 4.24 0.49 ＜0.01 ↑ Licorice glycoside C1 765.18 0.64 0.82 2.27 0.19 ＜0.01 ↑ Fatty Acyls cis-Uvariamicin IB 627.48 11.55 2.27 1.32 1268.67 ＜0.01 ↓ 3,4-Dimethyl-5-pentyl-2-furanpentadecanoic acid 857.68 12.57 -9.88 1.54 130.24 ＜0.01 ↓ 15-hydroxyicosanoic acid 698.63 13.78 -0.76 4.76 11.33 ＜0.01 ↓ 2-hydroxyhexadecanoic acid 271.23 8.73 0.84 2.08 0.47 0.01 ↑ 3-hydroxyhexadecanoyl carnitine 416.34 8.99 2.02 2.15 0.43 0.01 ↑ Aminocaproic acid 132.1 1.17 0.75 1.42 0.04 ＜0.01 ↑ Carboxylic acids and derivatives Tyrosyl-Isoleucine 293.15 2.31 -0.33 1.53 0.22 ＜0.01 ↑ L-Phenylalanine 164.07 1.71 0.73 1.03 0.09 ＜0.01 ↑ Benzene and substituted derivatives fluvoxamino acid 360.15 0.86 -8.35 2.72 0.53 ＜0.01 ↑ Table 3. Differences in metabolites enriched from specific pathways in milk of dairy cows receiving MCH infusions (7 days). Metabolic Pathway Metabolite Metabolic pathways (14) Maltose;SM(d18:1/22:1(13Z));SM(d18:0/22:1(13Z));Aminocaproic acid;9R, 10S-EpOME;Glucosylceramide (d18:1/16:0);L-Phenylalanine;SM(d18:0/16:1(9Z));Glucosylceramide (d18:1/25:0);SM(d18:0/24:1(15Z));SM(d18:1/23:0);SM(d18:0/14:0);PS(18:0/18:1(9Z));Galactosylceramide (d18:1/14:0) Sphingolipid metabolism (10) Galabiosylceramide (d18:1/16:0);SM(d18:1/22:1(13Z));SM(d18:0/22:1(13Z));Glucosylceramide (d18:1/16:0);SM(d18:0/16:1(9Z));Glucosylceramide (d18:1/25:0);SM(d18:0/24:1(15Z));Galactosylceramide (d18:1/14:0);SM(d18:0/14:0);SM(d18:1/23:0) Sphingolipid signaling pathway (6) SM(d18:1/22:1(13Z));SM(d18:0/22:1(13Z));SM(d18:0/16:1(9Z));SM(d18:0/24:1(15Z));SM(d18:0/14:0);SM(d18:1/23:0) Glycerophospholipid metabolism (6) LysoPC(P-18:0);LysoPC(18:1(11Z));LysoPC(18:1(9Z));PS(18:0/18:1(9Z));LysoPC(16:1(9Z)/0:0);LysoPC(20:4(5Z, 8Z, 11Z, 14Z)) ABC transporters (2) L-Phenylalanine; Maltose 2-Oxocarboxylic acid metabolism (1) L-Phenylalanine Aminoacyl-tRNA biosynthesis (1) L-Phenylalanine Amoebiasis (1) PS(18:0/18:1(9Z)) Biosynthesis of amino acids (1) L-Phenylalanine Carbohydrate digestion and absorption (1) Maltose Glycine, serine and threonine metabolism (1) PS(18:0/18:1(9Z)) Leishmaniasis (1) PS(18:0/18:1(9Z)) Linoleic acid metabolism (1) 9R, 10S-EpOME Mineral absorption (1) L-Phenylalanine Phenylalanine metabolism (1) L-Phenylalanine Phenylalanine, tyrosine and tryptophan biosynthesis (1) L-Phenylalanine Protein digestion and absorption (1) L-Phenylalanine Starch and sucrose metabolism (1) Maltose Systemic lupus erythematosus (1) PS(18:0/18:1(9Z)) Taste transduction (1) Maltose Table 4. Components and nutritional analysis of the total mixed rations (dry matter basis) Items Content Alfalfa hay 13. 34 Leymus chinensis 11. 20 Corn 15. 73 Whole cottonseed 3. 19 Maize silage 28. 57 DDGS 2. 99 Steam-flaked corn 7. 16 Soybean meal 11. 53 Cottonseed meal 3. 87 Premix1) 1. 96 NaCl 0. 46 Total 100. 00 Nutrient levels NEL/(MJ/kg)2) 7. 26 EE 4. 97 CP 17. 35 Neutral Washing Fiber NDF 30. 8 ADF 16. 5 Ca 0. 74 P 0. 41 Supplementary Files renamede61c7.docx Cite Share Download PDF Status: Under Revision Version 1 posted Editorial decision: Major revision 02 Sep, 2020 Review # 3 received at journal 01 Sep, 2020 Review # 2 received at journal 24 Aug, 2020 Reviewer # 4 agreed at journal 05 Aug, 2020 Reviewer # 2 agreed at journal 03 Aug, 2020 Reviewer # 3 agreed at journal 03 Aug, 2020 Review # 1 received at journal 21 Jul, 2020 Reviewer # 1 agreed at journal 01 Jul, 2020 Editor assigned by journal 17 May, 2020 Reviewers invited by journal 17 May, 2020 Submission checks completed at journal 16 May, 2020 Editor invited by journal 16 May, 2020 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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(A) Phylum level. (B) Relative abundance of the main bacterial phyla. (C) Differences in genera. (D) Differences in relative abundance of the main bacterial genera. The extended error bar plot was created with STAMP (Version v.2.1.3). Welch’s two-sided test was used, and Welch’s inverted test yielded 0.95.","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-26655/v1/3.png"},{"id":1152843,"identity":"c615cd3b-5782-46e6-9300-3749630544bb","added_by":"auto","created_at":"2020-05-21 19:10:17","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":178356,"visible":true,"origin":"","legend":"Principal component analysis score plot (A), permutation test plot (B) and orthogonal partial least squares discriminant analysis (OPLS-DA) (C) for days 1 and 7 based on milk metabolite profiles. The variation in the principal components is indicated on the axes. Each spot is one sample, and the days are shown as green circles for day 1 and blue triangles for day 7.","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-26655/v1/4.png"},{"id":1152844,"identity":"bd039f64-8b51-42cc-8565-d8ee9c2017f6","added_by":"auto","created_at":"2020-05-21 19:10:17","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":284606,"visible":true,"origin":"","legend":"Metabolic pathway enrichment analysis between day 1 and day 7. M, HD, EIP, OS and GIP are the names of the metabolic pathways in KEGG annotation. M, metabolism; HD, human diseases; EIP, environmental information processing; OS, organismal systems; GIP, genetic information processing.","description":"","filename":"5.png","url":"https://assets-eu.researchsquare.com/files/rs-26655/v1/5.png"},{"id":1152845,"identity":"1a9af53c-424c-4acb-a013-1474274d61d6","added_by":"auto","created_at":"2020-05-21 19:10:17","extension":"png","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":177435,"visible":true,"origin":"","legend":"Metabolome mapping of the differences in metabolite expression from day 1 to day 7. The abscissa shows pathway impact and the ordinate gives the p value. The bigger the circles the greater the number of metabolites enriched in the pathway. Darker colors indicate smaller p values.","description":"","filename":"6.png","url":"https://assets-eu.researchsquare.com/files/rs-26655/v1/6.png"},{"id":13532421,"identity":"8b51004b-d029-4a5f-b620-fad2409da6aa","added_by":"auto","created_at":"2021-09-17 01:17:00","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1613273,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-26655/v1/da1402ea-89c2-46f7-9f10-3ac841664024.pdf"},{"id":1152840,"identity":"b36d3d77-68e2-4bf6-b30b-0e56f8a3f206","added_by":"auto","created_at":"2020-05-21 19:10:16","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":638623,"visible":true,"origin":"","legend":"","description":"","filename":"renamede61c7.docx","url":"https://assets-eu.researchsquare.com/files/rs-26655/v1/renamede61c7.docx"}],"financialInterests":"","formattedTitle":"Matrine-chitosan hydrogels for treating subclinical bovine mastitis by intramammary infusion—effect on milk microbiome and metabolites","fulltext":[{"header":"1. Background","content":" \u003cp\u003eThe udder microbiota plays an important role in the host-pathogen interactions of the innate and adaptive immune system. This is especially true of pathogens that trigger inflammation that is detrimental to mammary tissue and bovine physiology [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. Mastitis is an inflammation of the udder most commonly from bacterial infection, and the pathological changes not only affect milk quality but also quantity [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. The increasing demand for animal protein has led to substantial growth in the use of antibiotics in food animal production [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e], which can cause antimicrobial resistance that is a global concern for treating human as well as farm animal diseases. Developing an effective drug for mastitis that is safe for use in food animals and for which no resistance exists in the microbial population would be highly desirable for the worldwide dairy industry.\u003c/p\u003e \u003cp\u003eMatrine is a polycyclic alkaloid isolated from the plant, Sophora flavescens that has been used in Chinese traditional medicine because of its anticancer, anti-inflammatory, cardioprotective, and opioid effects [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. Previous research [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e] found that matrine inhibited the virulence of Staphylococcus aureus, one of the main pathogens of mastitis. Furthermore, matrine attenuated the lipopolysaccharide-induced immune response by downregulating IL-1 and IL-17 and inhibiting production of the proinflammatory compound, malondialdehyde, reducing inflammation and oxidative stress, and enhancing CCR7 expression [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. Chitosan is a natural polymer produced by acetylation and enzymatic cleavage of chitin, which is the most abundant animal polysaccharide in nature.[\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. The applications for chitosan have continued to increase because of the abundance of its source, its biocompatibility and ease of chemical modification. Studies have also shown that chitosan has anti-inflammatory, antimicrobial, cholesterol-lowering, immunomodulatory, and antitumor properties [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. Chitosan can be beneficial at the cellular or molecular level [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e], by reducing intracellular material leakage and triggering an antimicrobial response to enhance the therapeutic effects of mastitis treatment. Chitosan can be formulated to be injectable at room temperature but change into a biodegradable hydrogel at body temperature [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e]. It has been used in drug formulations and delivery vehicles for decades; however, the influence of matrine and chitosan on the udders of dairy cows has received little research attention. Therefore, it is worthwhile to explore the effectiveness of intramammary infusion of matrine-loaded chitosan hydrogels (MCHs) on the udders of dairy cows with mastitis in terms of positively changing the microbial population and metabolic profile of milk. We hypothesized that intramammary injection of MCHs would favor the growth of beneficial microorganisms and cause a shift in the milk microbiota in normal udder quarters.\u003c/p\u003e \u003cp\u003eDNA sequencing has become routine for many labs and the advanced software and bioinformatics databases available have created great opportunities for studying pathogenic mechanisms [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. By understanding the host responses to microbial attack, we hope to be able to identify the most effective targets for antimicrobial intervention, to develop new treatments for bovine mastitis and to find sensitive biomarkers for early detection and diagnosis. Metabolomics can also be used for quantitative measurement of the metabolic state of milk, including the biomarkers of lactation [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e], the variation in metabolites associated with mastitis[\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e], and differences in metabolism after antibacterial therapy [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]. Little is known about the changes in milk metabolites in response to MCH treatment of mastitis, and one of the goals of this study was to obtain detailed information on the effect of matrine delivery by chitosan hydrogel injection into bovine mammary glands on milk microbiota and metabolites. We investigated the effects MCHs on subclinical-mastitis and the relationship between milk microbiota diversity and metabolite profiles, to probe the mechanisms of the antibacterial benefits of matrine and chitosan for mastitis, and to provide new knowledge for the development of novel, safe and effective prophylactic and therapeutic compounds for dairy cow operations.\u003c/p\u003e "},{"header":"2. Results","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e\n\u003ch2\u003e2.1. Somatic cell counts in milk\u003c/h2\u003e\n\u003cp\u003eMatrine-chitosan hydrogels significantly decreased the somatic cell count on day 7 compared to day 1 (p\u0026thinsp;\u0026lt;\u0026thinsp;0. 05) (Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e1\u003c/span\u003e).\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec4\" class=\"Section2\"\u003e\n\u003ch2\u003e2.2. Diversity and relative numbers of milk microbiota\u003c/h2\u003e\n\u003cp\u003eA total of 1,117,565 high-quality sequences from twelve samples passed quality control and could be used for testing. The sequences averaged 308\u0026nbsp;bp, and there was greater than ninety-nine percent depth coverage; therefore, the amount of data was sufficient to show differences in all bacterial species. The \u0026alpha;-diversity indices of the microbiota are shown in table 1. Although ACE showed a tendency to decrease, no different was observed in the Chao indices, which were all representative of bacterial community richness. Moreover, the Simpson index showed that the bacterial diversity at day 7 was significantly lower than at day 1 (p༜0.05), and there was an overall tendency to decrease (p\u0026thinsp;=\u0026thinsp;0.06), but this is variable and depends on if the calculations are based on abundance or biomass. No significant differences were seen among the groups for the other \u0026alpha;-diversities.\u003c/p\u003e\n\u003cp\u003ePrincipal component analysis (PCA) on the microbial populations present on day 1 vs day 7 showed clear differences, and the weighted UniFrac values were also determined (Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e2\u003c/span\u003e). Principal coordinates one and two were found to account for 51.76 and 26.2% of total variance, confirming that the milk microbiome after seven days of MCH infusion was remarkably distinct from that on day one.\u003c/p\u003e\n\u003cp\u003eThe taxonomic changes in milk samples from day 1 to day 7 were determined. \u003cem\u003eProteobacteria, Firmicutes, Actinobacteria\u003c/em\u003e and \u003cem\u003eBacteroidetes\u003c/em\u003e were the three predominant phyla (Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003eA). The abundance of \u003cem\u003eFirmicutes\u003c/em\u003e was extremely significantly decreased on day 7 (p\u0026thinsp;=\u0026thinsp;0.01), whereas the numbers of \u003cem\u003eProteobacteria\u003c/em\u003e increased (p\u0026thinsp;=\u0026thinsp;0.01) (Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003eA, B). Taxa with a relative abundance of one percent in at least one sample were identified, and the ten most abundant genera are presented (Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e3\u003c/span\u003eC, D). On day 7, there was a significantly lower abundance of Aerococcus (p\u0026thinsp;=\u0026thinsp;0.01), Corynebacterium_1 (p\u0026thinsp;=\u0026thinsp;0.08) and Staphylococcus (p\u0026thinsp;=\u0026thinsp;0.03). In contrast, the relative abundances of Pseudomonas (p\u0026thinsp;=\u0026thinsp;0.01) and Ralstonia (p\u0026thinsp;=\u0026thinsp;0.02) were significantly increased.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec5\" class=\"Section2\"\u003e\n\u003ch2\u003e2.3. Identification and comparison of milk metabolites\u003c/h2\u003e\n\u003cp\u003eA non-targeted metabolome method was used to evaluate milk metabolites after MCH treatment. Reproducible metabolite data profiles (1001) were obtained and differences between day 1 and day 7 were characterized using VIP metrics from OPLS-DA. Seventy-four milk metabolite signals were obtained that were significantly different between MCH-treated and untreated cows (VIP\u0026thinsp;\u0026gt;\u0026thinsp;1 and p\u0026thinsp;\u0026lt;\u0026thinsp;0.05) (table 2). They consisted mainly of sphingolipids, oxanes, glycerophospholipids, flavonoids and fatty acyls. Milk from animals receiving MCHs for seven days had higher levels of steroids and steroid derivatives, prenol lipids, oxanes, macrolides and analogues, hydroxy acids and derivatives, carboxylic acids and derivatives and Benzene and substituted derivatives than milk on day 1.\u003c/p\u003e\n\u003cp\u003ePCA and OPLS-DA were employed to evaluate the differences in metabolomes. The PCA scores showed clear differences between day 1 and day 7 milk samples (Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003eA). Principal components one and two were found to account for 31.70% and 16.10% of the variation. The variables for assessing OPLS-DA model quality are shown in validation plots (Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003eB). The Q2 value of the OPLS-DA model was 0.939, and the R2Y value was 0.963. Q2 represents the model\u0026rsquo;s prediction ability and the closer these 3 indicators are to 1, the more stable and reliable it is. Q2\u0026thinsp;\u0026gt;\u0026thinsp;0.5 indicates that the model\u0026rsquo;s prediction ability is good, while Q2\u0026thinsp;\u0026lt;\u0026thinsp;0.5 indicates poor predictability. The OPLS-DA data confirmed that the two groups had significantly different types and levels of metabolites (Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e4\u003c/span\u003eC). OPLS-DA model integrity is shown by validation plots. The day 7 metabolite profiles were significantly different from those of day 1 indicating that the PCA and OPLS-DA results were valid for assessing variations in milk metabolomes between the two days.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec6\" class=\"Section2\"\u003e\n\u003ch2\u003e2.4. Differences in metabolites resulting from changes in metabolic pathways\u003c/h2\u003e\n\u003cp\u003eComparison of metabolism via changes in pathway activation from MCH treatment on day 1 to 7 was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) for determining enrichment of pathways involved in metabolite production (table 3; Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e5\u003c/span\u003e). Enrichment analysis showed that sphingolipid metabolism, the sphingolipid signaling pathway, glycerophospholipid metabolism and ABC transporters, were significantly affected by MCH injection.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003ePathway topology analysis (Fig.\u0026nbsp;\u003cspan class=\"InternalRef\"\u003e6\u003c/span\u003e) (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05) revealed 8 key pathways enriched between days 1 and 7. They included sphingolipid, phenylalanine, glycerophospholipid, and starch and sucrose metabolism, synthesis of phenylalanine, tyrosine and tryptophan and linoleic acid metabolism.\u003c/p\u003e\n\u003c/div\u003e"},{"header":"3. Discussion","content":" \u003cp\u003eThe results of this study revealed that MCHs markedly decreased somatic cell count after 7 days of treatment. Although we did not observe any changes in bacterial community richness by the Chao indices, the Simpson index showed a significant decrease in the bacterial diversity. In particular, on day 7, the relative abundance of \u003cem\u003eFirmicutes\u003c/em\u003e was significantly decreased, and that of \u003cem\u003eProteobacteria\u003c/em\u003e was significantly increased compared to levels on day 1. It has been reported that the richness and diversity of the milk microbiome reflects the health of the cows and functional performance of the organs [\u003cspan additionalcitationids=\"CR17\" citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. \u003cem\u003eAntibacterials\u003c/em\u003e are commonly used to treat bovine mastitis, but their efficacy is unclear [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. That is why we chose to test the plant-derived compound, matrine, as an intramammary treatment loaded into chitosan hydrogels to see if it would alter the milk microbiota and improve mammary gland function.\u003c/p\u003e \u003cp\u003eMeasurement of the number of somatic cells in milk is an internationally recognized test for the detection of mastitis. A SCC of more than 200,000 per ml is considered to be evidence of disease[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. Recent investigations have shown that the milk microbiota of dairy cows are usually closely associated with the SCC [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e, \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. This suggests that modulation of the udder ecosystem through the microbiota could help to maintain homeostasis and enhance the mammary gland\u0026rsquo;s defense mechanism [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]Consistent with these reports, we observed that the udder SCC was significantly increased by in mastitis by common pathogens like Staphylococcus, but was markedly decreased after perfusion of the udder with matrine-chitosan hydrogel. This is in line with previous studies showing that chitosan hydrogels decreased the SCC in milk from dairy cows[\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. The therapeutic synergy achieved by loading the chitosan hydrogel with matrine suggests potential application in mastitis protection and treatment. The mechanism by which the milk microbiota influences inflammatory and immune responses to decrease the SCC still needs further investigation.\u003c/p\u003e \u003cp\u003eThe next generation of high-throughput DNA sequencing methods together with updated bioinformatics software is now being used for the in-depth assessment of microbial communities to elucidate how bacterial activity and metabolites affect human and animal health [\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]. We found that the microbial diversity in milk was dramatically decreased after one week of intramammary infusions of matrine-chitosan hydrogels. The relative abundance of \u003cem\u003eProteobacteria\u003c/em\u003e was significantly increased, while \u003cem\u003eStaphylococcus\u003c/em\u003e numbers decreased significantly. \u003cem\u003eStaphylococci\u003c/em\u003e are internationally recognized as one of the most prevalent mastitis pathogens, accounting for about 70% of the cases [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e].. Moreover, it has been reported that \u003cem\u003eProteobacteria\u003c/em\u003e are significantly more abundant in healthy cows than those with mastitis[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. Previous studies also showed that the numbers of \u003cem\u003eProteobacteria\u003c/em\u003e after non-antibiotic hydrogel treatment increased significantly [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e], indicating that hydrogel therapy can effectively return the milk microbial environment to normal diversity and defend against disease. Our investigation provides mechanistic insights into how the microbiota respond to MCH may help in the development of novel prophylactic and therapeutic products as alternatives to antibiotics in dairy cows. Our data are also important for understanding how the regulation of biosynthesis by milk microbiota influences udder health and defense against mastitis. The milk microbiota are usually closely associated with the SCC [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e, \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. suggesting that the udder microbiota plays an important part in modulation of the ecosystem and maintenance of homeostasis to resist mammary gland infections [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]\u003c/p\u003e \u003cp\u003eMetabolomics is a comparatively new research method that has been widely used in the detection of mastitis in recent years due to its more comprehensive test results. Previous studies suggested that metabolomics could provide a more complete understanding of an animal\u0026rsquo;s physiology and biochemistry .[\u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e]. The metabolomics data from this study highlight the potential function of matrine-chitosan hydrogels in modulating the metabolite levels, which were found to be enriched in sphingolipid metabolic pathways, phenylalanine, glycerophospholipid, and starch and sucrose metabolism. A previous report suggested that sphingolipid metabolites acted as signaling molecules to regulate a diverse group of cellular processes, particularly those related to immunity, inflammation and inflammatory disorders .[\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e]. We speculate that this activity might be associated with the decrease in SCC caused by matrine-chitosan hydrogel injection. The metabolic differences we observed gave us a further insight into how MCH affects metabolite levels before and after mastitis treatment, and showed that alterations in the milk metabolome could be used to reveal the therapeutic mechanism of matrine for mastitis treatment and in the recovery of milk production in dairy cows.\u003c/p\u003e \u003cp\u003eWe found significant changes in concentration of a number of sphingolipids, glycerolipids, fatty acyls, glycerophospholipids, and organo-oxygen compounds that significantly differed from day 1 to day 7. Sphingolipids are major components of cell membranes and are considered to be widely involved in important processes such as cell aging and apoptosis .[\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e]. Glycerolipids [\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e] and fatty acyls [\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e] are both important components of cell membranes. Previous research found that bacterial invasion can induce inflammatory reactions and cause oxidative damage during the development of the breast [\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e], accompanied by apoptosis .[\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e, \u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e]. The reduction in sphingolipids, glycerolipids, and fatty acyls seen in this study indicates that apoptosis caused by inflammatory reactions may have been weakened. The decrease of organooxygen compounds suggests that the oxidative damage caused by inflammatory reactions may also have been reduced. The metabolites were enriched in sphingolipid and glycerophospholipid metabolism[\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e], which are both related to apoptosis pathways.[\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e, \u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e]. Therefore, we conclude that MCHs can inhibit apoptosis by blocking oxidative damage, thereby reducing inflammatory changes to the udder.\u003c/p\u003e \u003cp\u003eIt is worth noting that L-phenylalanine is involved in many pathways that are significantly changed in this study (table 3). L-phenylalanine is an essential amino acid and a precursor for the synthesis of antiviral and anticancer drugs as well as new sweeteners. It can also be a marker of inflammatory reactions and affect the body's immune response [\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e]. Here, the content of L-phenylalanine was significantly increased on day 7, which means that the immune defenses in the mammary gland may have been effectively improved. Previous study [\u003cspan citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e] found that tryptophan and phenylalanine are used in the body to synthesize serotonin, L-DOPA derivatives and 5, 6, 7, 8-tetrahydrobiopterin (BH4), which compounds can affect the severity of inflammation. In the study of Smith ,[\u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e39\u003c/span\u003e], tyrosine and phenylalanine participated in the regulation of TLR4 signaling pathways, thereby influencing the degree of inflammation. Phenylalanine also is part of the glycolytic and liposynthetic pathways.[\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e, \u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e]. It has been reported that phenylalanine deficiency can severely affect protein metabolism in the breast and compromise the health of the organ.[\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e]. Phenylalanine is an essential amino acid in milk and is also the precursor of tyrosine, which is one of the main amino acids in milk.[\u003cspan citationid=\"CR43\" class=\"CitationRef\"\u003e43\u003c/span\u003e]. We know that untreated bovine mastitis results in reduced milk fat and milk protein content; therefore, the increase in L-phenylalanine by MCH injection could be effective in restoring normal milk production during lactation.\u003c/p\u003e \u003cp\u003eThe milk metabolites produced by MCH injection were found to have an intimate relationship with sphingolipid and glycerophospholipid metabolism. A previous study suggested that the sphingolipid metabolic pathways participate in a variety of immune-related signal transductions, inflammation and inflammatory disorders [\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e]. The sphingolipid metabolism-related pathways have many functions, such as regulating cell adhesion and cellular immunity, activating cancer repressors, regulating apoptosis, and modulating immune function and the inflammatory response [\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e] We speculate that this activity might be associated with the decrease in SCC caused by MCH injection. Furthermore, Cowart et al. [\u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e] showed that an imbalance in the pathway for sphingolipid metabolism can cause ketosis, mastitis, and metritis in cows. It has been proved that sphingolipid metabolites, especially ceramide and sphingosine-1-phosphate, can regulate a variety of biochemical processes important in immune, inflammation and inflammatory diseases[\u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e]. In the present study, we found that MCHs could significantly regulate the sphingolipid metabolism-related pathways to improve inflammation; thus, it is reasonable to believe that MCHs could effectively treat bovine mastitis.\u003c/p\u003e \u003cp\u003eDespite the documented health-promoting properties of matrine and chitosan, scientific evidence for the efficacy of MCHs in dairy cows is limited. Our study affords many useful insights, but the effect of MCHs on immune regulation still requires further study. Another limitation relates to the mechanistic links involved in the observed significant changes in the microbiota and biomarker metabolites as a result of MCH injection that will need further exploration to be clearly understood. Previous studies suggested that the antimicrobial activity of chitosan can stimulate the innate immune response and hasten the involution process of the mammary gland[\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. It is not known whether matrine-chitosan complexes could be used in the circulation to regulate the immune system and inhibit inflammation, but our data indicate that future research in this area is strongly warranted.\u003c/p\u003e "},{"header":"4. Conclusions","content":" \u003cp\u003eOur data indicate that matrine-chitosan hydrogels significantly decrease the somatic cell counts and affect the structures of bacterial communities in the udder, especially the relative abundances of \u003cem\u003eCorynebacterium_1, Aerococcus\u003c/em\u003e and \u003cem\u003eStaphylococcus\u003c/em\u003e. These findings show significant changes in metabolites and metabolic pathways as a result of intramammary MCH infusion, and some of the resulting 74 milk metabolites may be used as indicators of the response to MCH treatment. The results from the milk metabolic pathway analysis are promising for the investigation of matrine-chitosan\u0026rsquo;s antimicrobial and anti-inflammatory properties that are closely associated with sphingolipid and glycerophospholipid metabolism. These insights into the complex mechanisms and corresponding biological responses highlight the beneficial action of matrine-chitosan hydrogels and justify continued investigations to identify the immunoregulatory mechanisms for treatment of mastitis dairy cows.\u003c/p\u003e "},{"header":"5. Methods","content":"\u003cdiv id=\"Sec10\" class=\"Section2\"\u003e\n\u003ch2\u003e5.1. Preparation of matrine-loaded chitosan hydrogels\u003c/h2\u003e\n\u003cp\u003eMatrine (98% purity) was purchased from Sigma-Aldrich Corp., St. Louis, MO, USA, and chitosan was purchased from Shanghai Sunny Biotech Co., Ltd., China. All solutions were prepared with nonpyrogenic products and materials under aseptic conditions in a laminar flow hood. The procedures were similar to those of Lanct\u0026ocirc;t et al. [\u003cspan class=\"CitationRef\"\u003e25\u003c/span\u003e]. Matrine (0.05\u0026nbsp;g) and 4\u0026nbsp;g of chitosan were added to 95\u0026nbsp;mL of deionized water and heated at 37\u0026nbsp;\u0026deg;C until the chitosan dissolved to obtain the matrine-loaded chitosan complexes. Ten ml of matrine-chitosan and 5\u0026nbsp;ml of 4% hydroxyethyl cellulose (2:1 ratio) were put into disposable plastic dishes (60\u0026nbsp;mm diameter) and mixed thoroughly. The water used was nonpyrogenic with \u0026lt;\u0026thinsp;0.005 endotoxin units/mL (Lonza, Walkersville, MD). For intramammary infusion, plastic syringes were filled with the 10\u0026nbsp;ml of MCH, sealed with a cap, and stored at room temperature.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec11\" class=\"Section2\"\u003e\n\u003ch2\u003e5.2. Animals and experimental design\u003c/h2\u003e\n\u003cp\u003eAnimals selected in this study were provided by the Beijing Sunlow Livestock Dairy Farming Center (Beijing, China), our animal protocols were reviewed and accepted by the Animal Care Committee of Beijing University of Agriculture in concordance with the guidelines for the use of bovines in research studies of the SSTCC (The State Science and Technology Commission of the P.R. of China, 2017). The dairy farm owner was consent to collect samples from cows for the presnet study. Samplings of untreated milk (n\u0026thinsp;=\u0026thinsp;580) were received from commercial dairies in Beijing from June to August 2019 with the California mastitis rapid detection reagent (CMT). Six mid-lactation cows with high somatic cell counts (SCC, average 250,000 cells/ml) indicative of subclinical-mastitis were selected according to their milk yield and parity. There were few initial differences in milk yield (27.2\u0026thinsp;\u0026plusmn;\u0026thinsp;1.8\u0026nbsp;kg/d), DIM (114.6\u0026thinsp;\u0026plusmn;\u0026thinsp;7.5 d), parity (2.6\u0026thinsp;\u0026plusmn;\u0026thinsp;0.4), or body weight (BW; 670\u0026thinsp;\u0026plusmn;\u0026thinsp;24\u0026nbsp;kg). The cows were fed a standard basal diet (table 4), had free access to water and were kept in a tie-stall barn. They received daily intramammary infusions of MCHs after each milking, twice daily, (7 AM and 7 PM) for 7 days. Milk samples were collected on the first day (D 1) and the last injection day (D 7) and totaled 15\u0026nbsp;ml per animal, with about equal volumes from each lactating udder quarter. Somatic cell counts were determined using an automatic cell counter (DeLaval International AB, Tumba, Sweden), and the remaining milk was stored in liquid nitrogen for later analysis. After the period of experimental, all dairy cows were back to the herd of cows after the veterinary examination and ensure they were healthy.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec12\" class=\"Section2\"\u003e\n\u003ch2\u003e5.3. Bacterial DNA isolated, 16S rRNA genes amplified and sequenced\u003c/h2\u003e\n\u003cp\u003eBacterial DNA was isolated from milk using a Power Soil DNA isolation kit (Qiagen, U.K.) as previously stated by Tong et al.[\u003cspan class=\"CitationRef\"\u003e14\u003c/span\u003e]. In brief, the DNA concentration and 260/280 ratio were measured with a NanoDrop 1000 spectrophotometer (Nanodrop Technologies, U.S.), and integrity was visualized by running aliquots on an agarose gel. The V1-V2 region of the 16S rRNA gene was PCR-amplified by (GeneAmp 9700, ABI, U.S.) using forward (5'-CGTATCGCCT-CCCTCGCGCCATCAG-3') and reverse (5'-CTA-TGCGCCTTGCCAGCCCGCTCAG-3') primers that incorporated adaptors and barcodes [\u003cspan class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e45\u003c/span\u003e]. Amplicons of about 450\u0026nbsp;bp were selected and combined in equal concentrations [\u003cspan class=\"CitationRef\"\u003e46\u003c/span\u003e], then electrophoresed and extracted from the gel with GeneJET (ThermoFisher, Waltham, MA, United States). Paired-end libraries were prepared by Majorbio Bio-Pharm (Shanghai, China). Bacterial ribosomal RNA genes were sequenced with Illumina HiSeq (Illumina, U.S.) for paired-end reads of three hundred base pairs. All raw sequence data were uploaded to NCBI (#SRP254162).\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec13\" class=\"Section2\"\u003e\n\u003ch2\u003e5.4. Analytical bioinformatics of milk microbiotas\u003c/h2\u003e\n\u003cp\u003eAnalyses were conducted with FLASH version 1.2.11 and quantitative insights into microbial ecology (QIIME) version 1.9.1. These programs gave data similar to that published by Tong et al. [\u003cspan class=\"CitationRef\"\u003e14\u003c/span\u003e]. Sequences were assigned to taxa by BLASTing the ribosomal database project (RDP) dbase using a 97% identity cut-off. Operational taxonomic units (OTUs) were normalized to relative abundance and bacterial composition was determined by Majorbio I-Sanger. Within-sample diversity (\u0026alpha;-diversity) was measured as bacterial community enrichment (ACE and Chao indices) and diversity (Shannon and Simpson indices) that were measured in a stochastic subset of the OTUs. Between-sample microbial diversity (\u0026beta;-diversity) was determined by phylogenetically-based weighted UniFrac distances [\u003cspan class=\"CitationRef\"\u003e47\u003c/span\u003e]. A more detailed picture of the diversity of the most abundant evolutionary clades in the bovine microbiota was obtained by filtering the OTUs to yield those with a relative abundance of \u0026ge;\u0026thinsp;1% for at least one sample.\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec14\" class=\"Section2\"\u003e\n\u003ch2\u003e5.5. Milk metabolome determination\u003c/h2\u003e\n\u003cp\u003eMilk samples were assessed by Majorbio Bio-Pharm using the LC-MS AB Sciex Triple TOF 5600TM (AB SCIEX, U.S.) according to published procedures [\u003cspan class=\"CitationRef\"\u003e14\u003c/span\u003e] The liquid chromatography conditions were similar to those of a previous study [\u003cspan class=\"CitationRef\"\u003e48\u003c/span\u003e]. Quality controls were run by combining milk samples and injecting them periodically during experimental measurements. The results were analyzed with XCMS (ver. 3.4.4). The retention times, MZ, observations and peak intensities were normalized with Excel. The differentially expressed metabolites were analyzed with the public database (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://metlin.scripps.edu/\u003c/span\u003e\u003c/span\u003e) on the Majorbio I-Sanger platform (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e\u003ca href=\"https://metlin.scripps.edu/\" target=\"_blank\"\u003ewww.i-sanger.com\u003c/a\u003e\u003c/span\u003e\u003c/span\u003e) and the KEGG pathway software for differential metabolite profiles (\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e\u003ca href=\"https://metlin.scripps.edu/\" target=\"_blank\"\u003ewww.metaboanalyst.ca/\u003c/a\u003e\u003c/span\u003e\u003c/span\u003e).\u003c/p\u003e\n\u003c/div\u003e\n\u003cdiv id=\"Sec15\" class=\"Section2\"\u003e\n\u003ch2\u003e5.6. Multivariate statistics\u003c/h2\u003e\n\u003cp\u003eComparisons were validated by Student\u0026rsquo;s t and p\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was defined as significant. Hierarchical clustering was conducted using the Bray-Curtis similarity index and the unweighted pair-group method with arithmetic averages. The SPSS software v.21.0 (IBM, Armonk, NY) was used. The \u0026alpha;-diversity indices are given as mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD. A p\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was considered statistically significant, and a p\u0026thinsp;\u0026lt;\u0026thinsp;0.10 suggested a trend. Principal component analysis and orthogonal partial least-squares-discriminant analysis (OPLS-DA) were carried out to show the metabolism changes among the experimental groups after mean centering and unit variance scaling. Parameters with variable importance in the projection (VIP) values\u0026thinsp;\u0026gt;\u0026thinsp;1.0 were allowed for group discriminant testing. Our OPLS-DA model was confirmed by 7-fold permutation testing. Significantly different metabolites among groups were assessed and identified by Wilcoxon rank-sum tests.\u0026nbsp;\u003c/p\u003e\n\u003c/div\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eMCHs: Matrine-chitosan hydrogels; PCA:Principal component analysis; OPLS-DA:Orthogonal partial least squares discriminant analysis; KEGG:Kyoto Encyclopedia of Genes and Genomes; M: metabolism; HD: human diseases; EIP: environmental information processing; OS: organismal systems; GIP: genetic information processing; SCC: somatic cell counts; CMT: California mastitis rapid detection reagent; RDP:Ribosomal database project; OTUs: Operational taxonomic units\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors thank the dairy barn staff for taking care of the cows, especially Kangkang Chu for providing technical assistance. The authors are grateful to Dandan He, from Shanghai Majorbio Bio-pharm Technology Co.,Ltd, for her assistant of the multivariate statistics analysis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eJJT, FXW and LSJ developed hypothesis, conceived the project and responsible for all data, figures and text. JJT, HZ, HN and FXW performed the experiments. FXW and HZ conducted data analysis. JJT and FXW wrote the manuscript. JJT, HZ, LSJ and BHX revised the paper. All authors carefully read the manuscript and agree to be held accountable for all aspects of the work.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was funded by the Project of the National Natural Science Foundation of China (Grant Nos. 31802091, 31702302 and 31772629) and the National Key Research and Development Plan (2016YFD0700205, 2016YFD0700201, and 2017YFD0701604). Jinjin Tong also thanks the China Postdoctoral Science Foundation and the Beijing Postdoctoral Science Foundation. Linshu Jiang thanks for the Beijing million Talents Project.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe animal protocols were reviewed and accepted by the Animal Care Committee of Beijing University of Agriculture in concordance with the guidelines for the use of bovines in research studies of the SSTCC (The State Science and Technology Commission of the P.R. of China, 2017).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot Applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflicts of Interest\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no conflicts of interest regarding this work\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor details\u003c/strong\u003e\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e \u003cspan\u003eDerakhshani H, Plaizier JC, De Buck J, Barkema HW, Khafipour E: \u003cb\u003eAssociation of bovine major histocompatibility complex\u003c/b\u003e (\u003cb\u003eBoLA\u003c/b\u003e) \u003cb\u003egene polymorphism with colostrum and milk microbiota of dairy cows during the first week of lactation\u003c/b\u003e. \u003cem\u003eMICROBIOME\u003c/em\u003e 2018, \u003cb\u003e6\u003c/b\u003e(1):203.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eGao J, Barkema HW, Zhang L, Liu G, Deng Z, Cai L, Shan R, Zhang S, Zou J, Kastelic JP, et al. 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J DAIRY SCI. 2014;97(7):4208\u0026ndash;15.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eLi Y, Hu X, Shuang Y, Zhou J, Lei Q, Sun X, Fan M, Xu S, Muha C, Zhang M. Comparison Between the Fecal Bacterial Microbiota of Healthy and Diarrheic Captive Musk Deer. FRONT MICROBIOL. 2018;9:300.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eLozupone C, Knight R. UniFrac: a New Phylogenetic Method for Comparing Microbial Communities. Applied Environmental Microbiology. 2006;71(12):8228\u0026ndash;35.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eWang X, Sun G, Feng T, Zhang J, Huang X, Wang T, Xie Z, Chu X, Yang J, Wang H, et al. Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer\u0026rsquo;s disease progression. CELL RES. 2019;29(10):787\u0026ndash;803.\u003c/span\u003e \u003c/li\u003e\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10px; line-height: 26.666664123535156px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003eTable 1. Alpha diversity indices for milk microbiota\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width: 399.15pt;border-collapse: collapse;\" width=\"532\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.4pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5.4pt;height: 16pt;\" width=\"24.390243902439025%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eItem\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118.2pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 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style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eShannon\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118.2pt;padding: 0in 5.4pt;height: 15.2pt;\" width=\"29.643527204502814%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.35\u0026plusmn;0.52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118.2pt;padding: 0in 5.4pt;height: 15.2pt;\" width=\"29.643527204502814%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.92\u0026plusmn;0.36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.35pt;padding: 0in 5.4pt;height: 15.2pt;\" width=\"16.322701688555348%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 97.4pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5.4pt;height: 15.6pt;\" width=\"24.390243902439025%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCoverage\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118.2pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5.4pt;height: 15.6pt;\" width=\"29.643527204502814%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.99\u0026plusmn;0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 118.2pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5.4pt;height: 15.6pt;\" width=\"29.643527204502814%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.99\u0026plusmn;0.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.35pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in 5.4pt;height: 15.6pt;\" width=\"16.322701688555348%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e\u003cstrong\u003eTable 2.\u003c/strong\u003e\u0026nbsp;Milk metabolites on day 1 compared to day 7 after MCH treatment\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse: collapse;\" width=\"830\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMetabolite\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eM/Z\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eRetention time\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMass Error\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eVIP\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFC(d1/d7)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eP value\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTendency\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSteroids and steroid derivatives\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e12b-Hydroxy-5b-cholanoic acid\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e418.35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePregnanetriolone\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e349.24\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-0.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.026\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAginoside progenin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e814.46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-2.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSphingolipids\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n 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0);\"\u003e859.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e13.36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3208275862\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSM(d18:1/23:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e845.68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e12.95\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.26\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11748.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSM(d18:1/22:1(13Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e829.65\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.59\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e369.77\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSM(d18:0/22:1(13Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e831.66\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e12.73\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGlucosylceramide (d18:1/16:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e744.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: 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0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e27.94\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGlucosylceramide (d18:1/25:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e790.69\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003estearoyl sphingomyelin\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e775.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11.48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, 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Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e19.61\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN-hexadecanoylsphinganine-1-phosphocholine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e749.58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e16.13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGalabiosylceramide (d18:1/16:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e906.62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSM(d18:0/14:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e721.55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: 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0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e6.89\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN-Glycoloylganglioside GM2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e708.61\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAraliacerebroside\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e776.55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGanglioside GM1 (d18:1/18:1(11Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e772.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003enLc6Cer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e696.82\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: 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0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n 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style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.96\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-3.62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e325.11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-0.78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eOrganooxygen compounds\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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rgb(0, 0, 0);\"\u003e475.13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-1.46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eN6-Galacturonyl-L-lysine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e357.11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e365.11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e6.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMacrolides and analogues\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePectenotoxin 7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e909.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-1.88\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.95\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e31-O-Demethyltacrolimus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e810.44\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-1.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.03\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIndoles and derivatives\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIndole-3-carboxilic acid-O-sulphate\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e240\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eHydroxy acids and derivatives\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2-Hydroxy-3-methoxyestrone\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e442.35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9.08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGlycerophospholipids\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePE(15:0/22:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e806.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11.84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e48.31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePE(14:0/22:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e792.58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11.45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8.49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePS(DiMe(11,3)/MonoMe(11,5))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e880.54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: 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0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11.77\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.77\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e6.11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003elysoPC(6:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e400.17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-1.21\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.51\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.96\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePE(18:2(9Z,12Z)/18:1(11Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e786.53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e12.04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e7.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.99\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePE(15:0/16:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e722.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e10.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.85\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9.94\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.99\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11.24\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e5.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePS(16:0/18:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e784.52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLysoPE(0:0/18:2(9Z,12Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePE(18:1(9Z)/16:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.03\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" 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style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.03\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.71\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" 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style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8.31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.94\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.45\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.41\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" 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5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLysoPE(18:2(9Z,12Z)/0:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e478.29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLysoPE(0:0/22:5(7Z,10Z,13Z,16Z,19Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" 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style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e520.34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e7.69\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1-(8Z,11Z,14Z-eicosatrienoyl)-glycero-3-phosphate\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e502.29\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: 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style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 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style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8.59\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTG(16:1(9Z)/16:1(9Z)/16:1(9Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 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10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMG(0:0/16:0/0:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e365.25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8.94\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-0.54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.027\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFlavonoids\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMenthoside\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e723.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.69\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eIsoscoparin 2\u0026#39;\u0026#39;-(6-(E)-ferulylglucoside)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e781.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-0.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.37\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eKaempferol 3-(2\u0026#39;\u0026#39;-rhamnosylgalactoside) 7-rhamnoside\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e777.16\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-1.93\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.24\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLicorice glycoside C1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e765.18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.82\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.19\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eFatty Acyls\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ecis-Uvariamicin IB\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e627.48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11.55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1268.67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3,4-Dimethyl-5-pentyl-2-furanpentadecanoic acid\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e857.68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e12.57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-9.88\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e130.24\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e15-hydroxyicosanoic acid\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e698.63\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e13.78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-0.76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e4.76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026darr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2-hydroxyhexadecanoic acid\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e271.23\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8.73\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.84\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3-hydroxyhexadecanoyl carnitine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e416.34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e8.99\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAminocaproic acid\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e132.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCarboxylic acids and derivatives\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTyrosyl-Isoleucine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e293.15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-0.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eL-Phenylalanine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e164.07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.71\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.73\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e1.03\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"8\" style=\"width: 622.45pt;padding: 0in 5.4pt;height: 21.1pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eBenzene and substituted derivatives\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 212.1pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"34.096385542168676%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003efluvoxamino acid\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"10.240963855421686%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e360.15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"10%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 57.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.27710843373494%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e-8.35\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58.75pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.397590361445783%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2.72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.25pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.879518072289157%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0.53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"8.072289156626505%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e＜0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.6pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 22.45pt;vertical-align: top;\" valign=\"top\" width=\"9.036144578313253%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u0026uarr;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e\u003cstrong\u003eTable 3.\u0026nbsp;\u003c/strong\u003eDifferences in metabolites enriched from specific pathways in milk of dairy cows receiving MCH infusions (7 days).\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse: collapse;\" width=\"100%\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;border-top-width: 1.5pt;border-style: solid none;border-top-color: black;border-bottom-width: 1.5pt;border-bottom-color: black;padding: 0in 5.4pt;height: 14.65pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMetabolic Pathway\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;border-top-width: 1.5pt;border-style: solid none;border-top-color: black;border-bottom-width: 1.5pt;border-bottom-color: black;padding: 0in 5.4pt;height: 14.65pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMetabolite\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMetabolic pathways (14)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMaltose;SM(d18:1/22:1(13Z));SM(d18:0/22:1(13Z));Aminocaproic acid;9R, 10S-EpOME;Glucosylceramide (d18:1/16:0);L-Phenylalanine;SM(d18:0/16:1(9Z));Glucosylceramide (d18:1/25:0);SM(d18:0/24:1(15Z));SM(d18:1/23:0);SM(d18:0/14:0);PS(18:0/18:1(9Z));Galactosylceramide (d18:1/14:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSphingolipid metabolism (10)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGalabiosylceramide (d18:1/16:0);SM(d18:1/22:1(13Z));SM(d18:0/22:1(13Z));Glucosylceramide (d18:1/16:0);SM(d18:0/16:1(9Z));Glucosylceramide (d18:1/25:0);SM(d18:0/24:1(15Z));Galactosylceramide (d18:1/14:0);SM(d18:0/14:0);SM(d18:1/23:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSphingolipid signaling pathway (6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSM(d18:1/22:1(13Z));SM(d18:0/22:1(13Z));SM(d18:0/16:1(9Z));SM(d18:0/24:1(15Z));SM(d18:0/14:0);SM(d18:1/23:0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGlycerophospholipid metabolism (6)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLysoPC(P-18:0);LysoPC(18:1(11Z));LysoPC(18:1(9Z));PS(18:0/18:1(9Z));LysoPC(16:1(9Z)/0:0);LysoPC(20:4(5Z, 8Z, 11Z, 14Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eABC transporters (2)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eL-Phenylalanine; Maltose\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2-Oxocarboxylic acid metabolism (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eL-Phenylalanine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAminoacyl-tRNA biosynthesis (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eL-Phenylalanine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAmoebiasis (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePS(18:0/18:1(9Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eBiosynthesis of amino acids (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eL-Phenylalanine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCarbohydrate digestion and absorption (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMaltose\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eGlycine, serine and threonine metabolism (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePS(18:0/18:1(9Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLeishmaniasis (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePS(18:0/18:1(9Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLinoleic acid metabolism (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e9R, 10S-EpOME\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMineral absorption (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eL-Phenylalanine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePhenylalanine metabolism (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eL-Phenylalanine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePhenylalanine, tyrosine and tryptophan biosynthesis (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eL-Phenylalanine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eProtein digestion and absorption (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eL-Phenylalanine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eStarch and sucrose metabolism (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMaltose\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSystemic lupus erythematosus (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;padding: 0in 5.4pt;height: 13.9pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003ePS(18:0/18:1(9Z))\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 289.5625px;border-style: none none solid;border-bottom-width: 1.5pt;border-bottom-color: black;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"33.333333333333336%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eTaste transduction (1)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 1571.328125px;border-style: none none solid;border-bottom-width: 1.5pt;border-bottom-color: black;padding: 0in 5.4pt;height: 14.25pt;vertical-align: bottom;\" valign=\"bottom\" width=\"66.66666666666667%\"\u003e\n \u003cp style=\"margin: 0in 0in 0.0001pt;font-size:14px;font-family: Calibri, sans-serif;text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMaltose\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: left; font-size: 14px; font-family: Calibri, sans-serif; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e\u003cstrong\u003eTable 4.\u0026nbsp;\u003c/strong\u003eComponents and nutritional analysis of the total mixed rations (dry matter basis)\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse: collapse;border: none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eItems\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border-top-width: 1pt;border-style: solid none;border-top-color: windowtext;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;line-height: 16.100000381469727px;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"line-height: 15.333332061767578px;\"\u003eContent\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eAlfalfa hay\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e13. 34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eLeymus chinensis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e11. 20\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCorn\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e15. 73\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eWhole cottonseed\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e3. 19\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eMaize silage\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e28. 57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eDDGS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e2. 99\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eSteam-flaked corn\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 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Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e16. 5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eCa\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border: none;padding: 0in 5.4pt;height: 14.2pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e0. 74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 259.1pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 3.15pt;vertical-align: top;\" valign=\"top\" width=\"61.49732620320856%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003eP\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 161.9pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: windowtext;padding: 0in 5.4pt;height: 3.15pt;vertical-align: top;\" valign=\"top\" width=\"38.50267379679144%\"\u003e\n \u003cp style='margin: 0in 0in 0.0001pt;font-size:14px;font-family: \"Times New Roman\", serif;text-align: left;'\u003e\u003cspan style=\"color: rgb(0, 0, 0); font-size: 10px; font-family: Verdana, Geneva, sans-serif;\"\u003e0. 41\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-veterinary-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"Learn more about [BMC Veterinary Research](http://bmcvetres.biomedcentral.com/)","snPcode":"12917","submissionUrl":"https://submission.nature.com/new-submission/12917/3?","title":"BMC Veterinary Research","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"matrine-chitosan hydrogels, inflammatory factors, microbiome, metabolomics, subclinical-mastitis, dairy cows","lastPublishedDoi":"10.21203/rs.3.rs-26655/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-26655/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eBackground\u003c/p\u003e\u003cp\u003eThe metabolic processes of cows undergo significant changes during subclinical mastitis, but their molecular mechanisms have not been clearly elucidated. This study investigated the changes in milk metabolites after intramammary infusion of matrine, a plant alkaloid with anticancer properties, in the form of a chitosan hydrogel into bovine mammary glands with subclinical mastitis. Infusions were continued for seven days, and milk samples were collected on day 1 and day 7 for analysis of the microbiome by 16S rRNA gene sequencing and metabolites by liquid chromatography-mass spectrometry.\u003c/p\u003e\u003cp\u003eResults\u003c/p\u003e\u003cp\u003eMatrine-chitosan hydrogels (MCHs) significantly decreased the somatic cell count on day 7 and the Simpson index indicated that microbial diversity was significantly lower on day 7 than on day 1. On day 7, the numbers of \u003cem\u003eAerococcus, Corynebacterium_1\u003c/em\u003e and \u003cem\u003eStaphylococcus\u003c/em\u003e were significantly lower, while the abundance of \u003cem\u003eFirmicutes\u003c/em\u003e was very significantly decreased. The numbers of \u003cem\u003eProbacteria\u003c/em\u003e increased, however. In milk samples, we identified 74 differentially expressed metabolites and the MCH infusion group had the most significantly upregulated metabolites including sphingolipids, glycerophospholipids, flavonoids and fatty acyls. Principal component analysis and the orthogonal partial least squares discriminant test confirmed good separation of the milk metabolites. The identification of active milk metabolic pathways after MCH treatment supported the known antimicrobial and anti-inflammatory properties of matrine that are associated with glycerophospholipid metabolism and the sphingolipid metabolic signaling pathways.\u003c/p\u003e\u003cp\u003eConciusions\u003c/p\u003e\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"ql-cursor\"\u003e\u003c/span\u003e\u003c/strong\u003eThese insights into the mechanisms and the corresponding biological responses to matrine demonstrate its potential immunoregulatory activity and emphasize the need for continued investigation.\u003c/p\u003e","manuscriptTitle":"Matrine-chitosan hydrogels for treating subclinical bovine mastitis by intramammary infusion—effect on milk microbiome and metabolites","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-05-21 19:10:16","doi":"10.21203/rs.3.rs-26655/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Major revision","date":"2020-09-02T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-01T12:00:00+00:00","index":3,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's policy.\n"},{"type":"editorInvitedReview","content":"","date":"2020-08-24T12:00:00+00:00","index":2,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's policy.\n"},{"type":"reviewerAgreed","content":"","date":"2020-08-05T12:00:00+00:00","index":4,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-08-03T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-08-03T12:00:00+00:00","index":3,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-07-21T12:00:00+00:00","index":1,"fulltext":"Recommendation: Reviewer's comments unavailable due to the journal's policy.\n"},{"type":"reviewerAgreed","content":"","date":"2020-07-01T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorAssigned","content":"","date":"2020-05-17T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-05-17T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-05-16T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-05-16T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-veterinary-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"Learn more about [BMC Veterinary Research](http://bmcvetres.biomedcentral.com/)","snPcode":"12917","submissionUrl":"https://submission.nature.com/new-submission/12917/3?","title":"BMC Veterinary Research","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"7f8bac4e-5dc0-4ad9-a4b3-cd213d7ff6dd","owner":[],"postedDate":"May 21st, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"in-revision","subjectAreas":[{"id":104355,"name":"Small Animal Medicine"},{"id":104356,"name":"Large Animal Medicine"}],"tags":[],"updatedAt":"2020-09-03T23:32:57+00:00","versionOfRecord":[],"versionCreatedAt":"2020-05-21 19:10:16","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-26655","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-26655","identity":"rs-26655","version":["v1"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}