Endothelial c-Myc and doxorubicin-induced metabolic alterations: a multi-organ optical imaging study

Endothelial c-Myc and doxorubicin-induced metabolic alterations: a multi-organ optical imaging study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Journal of Biophotonics This is a preprint and has not been peer reviewed. Data may be preliminary. 13 February 2025 V1 Latest version Share on Endothelial c-Myc and doxorubicin-induced metabolic alterations: a multi-organ optical imaging study Authors : Parisa Nategh 0009-0009-2974-7742 , Mehrnoosh Neghabi , Busenur Ceyhan , Jacqueline F. Machi , Homan A. Rahbar , Maya S. Rodriguez , Aline G. Santana , Claudia O. Rodrigues , and Mahsa Ranji [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.173944468.86460960/v1 Published Journal of Biophotonics Version of record Peer review timeline 530 views 182 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Significance: Endothelial c-Myc plays a critical role in redox homeostasis, with its deletion potentially exacerbating oxidative stress, particularly during chemotherapy. Aim: To assess the metabolic impact of endothelial c-Myc knockout (KO) and doxorubicin (DOXO) treatment on kidneys, hearts, and livers using 3D optical cryo-imaging. Approach: Redox ratios (NADH/FAD) were analyzed in control (CT) and KO mice treated with DOXO or saline to evaluate mitochondrial function and oxidative states. Results: KO tissues showed significant reductions in redox ratios, indicating an oxidized state, with kidneys exhibiting up to a 51.42% decrease. DOXO treatment further exacerbated oxidative stress in KO tissues, while CT groups demonstrated protective effects. Conclusions: Endothelial c-Myc is crucial for redox balance and protection against chemotherapy-induced oxidative damage, offering insights for targeted therapeutic strategies. Supplementary Material File (final version-journal of biophotonics.docx) Download 3.26 MB Information & Authors Information Version history V1 Version 1 13 February 2025 Peer review timeline Published Journal of Biophotonics Version of Record 21 Apr 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Journal of Biophotonics Keywords cancer chemotherapy toxicity doxorubicin endothelial c-myc optical metabolic imaging redox ratio Authors Affiliations Parisa Nategh 0009-0009-2974-7742 Florida Atlantic University College of Engineering and Computer Science View all articles by this author Mehrnoosh Neghabi Florida Atlantic University College of Engineering and Computer Science View all articles by this author Busenur Ceyhan Florida Atlantic University College of Engineering and Computer Science View all articles by this author Jacqueline F. Machi Florida Atlantic University Charles E Schmidt College of Medicine View all articles by this author Homan A. Rahbar Florida Atlantic University Charles E Schmidt College of Medicine View all articles by this author Maya S. Rodriguez Florida Atlantic University Charles E Schmidt College of Medicine View all articles by this author Aline G. Santana Florida Atlantic University Charles E Schmidt College of Medicine View all articles by this author Claudia O. Rodrigues Florida Atlantic University Charles E Schmidt College of Medicine View all articles by this author Mahsa Ranji [email protected] Florida Atlantic University College of Engineering and Computer Science View all articles by this author Metrics & Citations Metrics Article Usage 530 views 182 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Parisa Nategh, Mehrnoosh Neghabi, Busenur Ceyhan, et al. Endothelial c-Myc and doxorubicin-induced metabolic alterations: a multi-organ optical imaging study. Authorea . 13 February 2025. DOI: https://doi.org/10.22541/au.173944468.86460960/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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