Modulation of Neural Correlates of Model-based Performance with Impulsivity and Compulsivity

Modulation of Neural Correlates of Model-based Performance with Impulsivity and Compulsivity | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Modulation of Neural Correlates of Model-based Performance with Impulsivity and Compulsivity Kerstin Dück, Raoul Wüllhorst, Rebecca Overmeyer, Tanja Endrass This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4465677/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 10 Sep, 2024 Read the published version in Scientific Reports → Version 1 posted 12 You are reading this latest preprint version Abstract Impaired goal-directed behavior is associated with a range of mental disorders, implicating underlying transdiagnostic factors. While compulsivity has been linked to reduced model-based (MB) control, impulsivity has rarely been studied in the context of reinforcement learning despite its links to reward processing and cognitive control. This study investigated the neural mechanisms underlying MB control and the influence of impulsivity and compulsivity. We analyzed EEG data from 238 individuals during a two-step decision making task. Single-trial analyses revealed that while feedback-related negativity (FRN) amplitudes were higher after common transitions and negative/neutral reward prediction error (RPE), the P3a and P3b were enhanced after rare transitions and both positive and negative RPE. In a second step, we regressed the mean b values of the effect of RPE on the EEG signals onto self-reported impulsivity and compulsivity and weighting parameter w (representing behavioral MB control). The effect of RPE on FRN-related activity was mainly associated with higher w scores. The interaction of impulsivity and w influenced both FRN- and P3a-related activity. The modulation of P3a by RPE was also negatively associated with compulsivity, pointing to a deficient mental model in highly compulsive individuals. Further research is needed to understand these alterations in decision-making processes. Biological sciences/Psychology Biological sciences/Psychology/Human behaviour Biological sciences/Neuroscience/Computational neuroscience Biological sciences/Neuroscience/Reward Biological sciences/Neuroscience/Cognitive neuroscience Biological sciences/Neuroscience/Cognitive neuroscience/Cognitive control Full Text Additional Declarations No competing interests reported. Supplementary Files 2stepSupp.docx Cite Share Download PDF Status: Published Journal Publication published 10 Sep, 2024 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 11 Jul, 2024 Reviews received at journal 10 Jul, 2024 Reviews received at journal 07 Jul, 2024 Reviewers agreed at journal 01 Jul, 2024 Reviewers agreed at journal 01 Jul, 2024 Reviewers agreed at journal 30 Jun, 2024 Reviewers agreed at journal 28 Jun, 2024 Reviewers invited by journal 27 Jun, 2024 Editor assigned by journal 27 Jun, 2024 Editor invited by journal 28 May, 2024 Submission checks completed at journal 24 May, 2024 First submitted to journal 23 May, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4465677","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":310513824,"identity":"f5e8b626-20d0-4f1b-b16b-f8ae5f6818f5","order_by":0,"name":"Kerstin Dück","email":"data:image/png;base64,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","orcid":"","institution":"Technische Universität Dresden","correspondingAuthor":true,"prefix":"","firstName":"Kerstin","middleName":"","lastName":"Dück","suffix":""},{"id":310513826,"identity":"151fb2f2-296a-41cd-ab3d-2ae07b5f06b2","order_by":1,"name":"Raoul Wüllhorst","email":"","orcid":"","institution":"Technische Universität Dresden","correspondingAuthor":false,"prefix":"","firstName":"Raoul","middleName":"","lastName":"Wüllhorst","suffix":""},{"id":310513827,"identity":"dca927a2-d483-4542-a4c0-ed1b4d152774","order_by":2,"name":"Rebecca Overmeyer","email":"","orcid":"","institution":"Technische Universität Dresden","correspondingAuthor":false,"prefix":"","firstName":"Rebecca","middleName":"","lastName":"Overmeyer","suffix":""},{"id":310513828,"identity":"d911c5e0-5da0-4c3c-8041-2853b0f15523","order_by":3,"name":"Tanja Endrass","email":"","orcid":"","institution":"Technische Universität Dresden","correspondingAuthor":false,"prefix":"","firstName":"Tanja","middleName":"","lastName":"Endrass","suffix":""}],"badges":[],"createdAt":"2024-05-23 09:10:38","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4465677/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4465677/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41598-024-71692-w","type":"published","date":"2024-09-10T15:57:30+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":64619077,"identity":"3fa60ada-391d-41a5-9919-201ef9e83684","added_by":"auto","created_at":"2024-09-16 16:11:14","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":986649,"visible":true,"origin":"","legend":"","description":"","filename":"2steppapertextSC.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4465677/v1_covered_f76be23f-d574-4d18-8aa0-66695dbb95cb.pdf"},{"id":57789600,"identity":"91d85e07-d37a-417b-b7d4-10b61650c860","added_by":"auto","created_at":"2024-06-05 17:16:58","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":467499,"visible":true,"origin":"","legend":"","description":"","filename":"2stepSupp.docx","url":"https://assets-eu.researchsquare.com/files/rs-4465677/v1/b152d65a2b3d7f9b3ffdad90.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Modulation of Neural Correlates of Model-based Performance with Impulsivity and Compulsivity","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4465677/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4465677/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eImpaired goal-directed behavior is associated with a range of mental disorders, implicating underlying transdiagnostic factors. While compulsivity has been linked to reduced model-based (MB) control, impulsivity has rarely been studied in the context of reinforcement learning despite its links to reward processing and cognitive control. This study investigated the neural mechanisms underlying MB control and the influence of impulsivity and compulsivity. We analyzed EEG data from 238 individuals during a two-step decision making task. Single-trial analyses revealed that while feedback-related negativity (FRN) amplitudes were higher after common transitions and negative/neutral reward prediction error (RPE), the P3a and P3b were enhanced after rare transitions and both positive and negative RPE. In a second step, we regressed the mean \u003cem\u003eb\u003c/em\u003e values of the effect of RPE on the EEG signals onto self-reported impulsivity and compulsivity and weighting parameter \u003cem\u003ew \u003c/em\u003e(representing behavioral MB control). 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