子宫内膜细胞及干细胞分离培养和鉴别方法的研究进展
article
OA: closed
CC0
Abstract
子宫内膜异位症(endometriosis,EMS)是子宫内膜间质细胞和腺上皮细胞种植于子宫腔外的雌激素依赖性疾病,具有易复发、侵袭性等恶性肿瘤样生物学特性[1].1978年,Prianishnikov[2]提出了子宫内膜干细胞的概念并认为其发展与干细胞相关.有学者报道,体外培养的异位子宫内膜细胞仍具有形成集落及分化能力提示异位的子宫内膜中可能存在干细胞[3-4].Du与Taylor[5]在异位内膜移入骨髓来源干细胞可分化为内膜细胞,也表明干细胞能够促进病变发展.尽管干细胞处于异位,但内膜本身能够转递信号直接复位干细胞.异位干细胞移行和分化可能是EMS发病的一种新机制.因此,建立体外研究的干细胞模型对于进一步研究EMS的分子发病机制具有重要意义[6]. 关键词：子宫内膜/细胞学;干细胞;细胞分离;细胞培养技术;综述
My notes (saved in your browser only)
Condition tags
Citation neighborhood (no data yet)
We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0
· commercial use OK