Adaptive Pharmacokinetic-Guided Blood Pressure Control: A Simulator for Personalized, Multi-Daily Ramipril Dosing

2025 · doi:10.22541/au.175915737.75305427/v1
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Abstract

Despite decades of pharmacologic research, hypertension management remains constrained by rigid, stepwise dose adjustments that fail to account for inter-individual variability. Inspired by continuous glucose monitoring in diabetes, we present a novel simulator of adaptive ramipril dosing based on pharmacokinetic accumulation, patient-specific sensitivity, circadian patterns, and stochastic variability. Multi-daily drug administrations are simulated with incremental dose adjustments to achieve systolic and diastolic blood pressure (BP) targets. Simulations demonstrate that personalized, multi-daily dosing maintains BP within ideal ranges more effectively than standard fixed-dose regimens. This work provides a conceptual foundation for wearableguided, real-time antihypertensive therapy.
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Abstract

Despite decades of pharmacologic research, hypertension management remains constrained by rigid, stepwise dose adjustments that fail to account for inter-individual variability. Inspired by continuous glucose monitoring in diabetes, we present a novel simulator of adaptive ramipril dosing based on pharmacokinetic accumulation, patient-specific sensitivity, circadian patterns, and stochastic variability. Multi-daily drug administrations are simulated with incremental dose adjustments to achieve systolic and diastolic blood pressure (BP) targets. Simulations demonstrate that personalized, multi-daily dosing maintains BP within ideal ranges more effectively than standard fixed-dose regimens. This work provides a conceptual foundation for wearableguided, real-time antihypertensive therapy. Supplementary Material File (4b84185e-973e-4eb0-ba80-e7415239ad01-2.pdf) - Download - 49.59 KB Information & Authors Information Version history Copyright This work is licensed under a Non Exclusive No Reuse License.

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Authors Metrics & Citations Metrics Article Usage 123views 107downloads Citations Download citation Edoardo Cervoni, Oliver Alessandro Cervoni. Adaptive Pharmacokinetic-Guided Blood Pressure Control: A Simulator for Personalized, Multi-Daily Ramipril Dosing. Authorea. 29 September 2025. DOI: https://doi.org/10.22541/au.175915737.75305427/v1 DOI: https://doi.org/10.22541/au.175915737.75305427/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu.

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