Recurrent Pancreatic Follicular Dendritic Cell Sarcoma: A Case Report and Literature Review

Background: Follicular Dendritic Cell Sarcoma (FDCS) is a rare malignant tumor originated from follicular dendritic cells. Presently radical resection is the standard treatment; however there is no clear optimal chemotherapy for unresectable lesions. We presented the clinical data, pathological features, imaging features, diagnosis and treatment of a very rare patient with recurrence and metastasis after radical resection of pancreatic FDCS. Case presentation: A 64-year-old male patient was delivered to hospital due to intermittent chest tightness and pain. A pancreatic mass was found after thorough physical examination. Enhanced MRI showed a round solid mass in the head and neck of pancreas. The patient underwent radical resection. The pathological diagnosis was FDCS. CHP regimen was used for consolidation chemotherapy for 6 cycles. Two years later, due to a large amount of effusion, the patient was confirmed to have relapse and extensive abdominal metastasis. Both CHOP regimen and bendamustine were ineffective. Conclusions: : FDCS of pancreas is very rare, and its imaging findings are not specific. If the disease relapses or metastases, though applies a variety of chemotherapy regimens, it is difficult to obtain satisfactory curative effect, and long-term prognosis is pessimistic. This is the first reported case that bendamustine was ineffective in the treatment of FDCS.