Shear Wave Elastography: Is the potential method in Assessing Anal Fistulas and Perianal Tissue strain？

Shear Wave Elastography: Is the potential method in Assessing Anal Fistulas and Perianal Tissue strain？ | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Short Report Shear Wave Elastography: Is the potential method in Assessing Anal Fistulas and Perianal Tissue strain？ Xiaochun Tao, Meng Hu, Haoqiang Yin, Jing Li, Jichun Si, Hongtao Liang, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7896382/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract BACKGROUND Shear wave elastography, an ultrasound-based technique, has been widely used in China to assess tissue stiffness, but its application in perianal tissues remains limited. This study investigates its potential for diagnosing anal fistulas and evaluating perianal tissue characteristics. METHOD Between January 1st, 2022, and April 30th, 2023, shear wave elastography was performed in 152 patients with single-site simple anal fistulas to evaluate normal perianal tissue, fistula tissue, and postoperative scar tissue following lay-open surgery. Statistical analyses, including receiver operating characteristic (ROC) curve analysis and logistic regression, were employed to establish reference thresholds for differentiating among these tissue types. RESULTS Young’s modulus can serve as a key indicator for differentiating perianal tissues of different types, including normal tissue, fistula tissue, and scar tissue, and its values are not affected by sex, age, or BMI. However, the measurement location significantly influenced the results. When distinguishing normal tissue from fistula tissue, a measurement at the 7 ~ 5 o’clock position (lithotomy position) yielded a threshold of > 40.08 kPa for identifying fistula tissue (preset threshold = 0.45), whereas a measurement at the 5 ~ 7 o’clock position suggested fistula tissue at a threshold of > 54.95 kPa. For scar tissue, Young’s modulus was independent of measurement location, with values > 104.34 kPa indicating fistula tissue. CONCLUSION Shecar wave elastography shows potential for diagnosing anal fistulas, differentiating tissues of different types, and evaluating postoperative prognosis, enhancing diagnostic accuracy and providing a convenient tool for clinical assessment. ultrasonic shear wave elastography anal fistula perianal tissue reference values evaluation tool Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7896382","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Short Report","associatedPublications":[],"authors":[{"id":544991667,"identity":"74e9cd7c-9f26-4a8b-a084-588875ee6e44","order_by":0,"name":"Xiaochun Tao","email":"","orcid":"","institution":"Longhua Hospital Shanghai University of TCM","correspondingAuthor":false,"prefix":"","firstName":"Xiaochun","middleName":"","lastName":"Tao","suffix":""},{"id":544991668,"identity":"f67d31e9-6d04-4e06-b6a5-3e96600ef1eb","order_by":1,"name":"Meng Hu","email":"","orcid":"","institution":"Longhua Hospital Shanghai University of 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strain？\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"ultrasonic shear wave elastography, anal fistula, perianal tissue, reference values, evaluation tool","lastPublishedDoi":"10.21203/rs.3.rs-7896382/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7896382/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBACKGROUND\u003c/h2\u003e\u003cp\u003eShear wave elastography, an ultrasound-based technique, has been widely used in China to assess tissue stiffness, but its application in perianal tissues remains limited. This study investigates its potential for diagnosing anal fistulas and evaluating perianal tissue characteristics.\u003c/p\u003e\u003ch2\u003eMETHOD\u003c/h2\u003e\u003cp\u003eBetween January 1st, 2022, and April 30th, 2023, shear wave elastography was performed in 152 patients with single-site simple anal fistulas to evaluate normal perianal tissue, fistula tissue, and postoperative scar tissue following lay-open surgery. Statistical analyses, including receiver operating characteristic (ROC) curve analysis and logistic regression, were employed to establish reference thresholds for differentiating among these tissue types.\u003c/p\u003e\u003ch2\u003eRESULTS\u003c/h2\u003e\u003cp\u003eYoung\u0026rsquo;s modulus can serve as a key indicator for differentiating perianal tissues of different types, including normal tissue, fistula tissue, and scar tissue, and its values are not affected by sex, age, or BMI. However, the measurement location significantly influenced the results. When distinguishing normal tissue from fistula tissue, a measurement at the 7\u0026thinsp;~\u0026thinsp;5 o\u0026rsquo;clock position (lithotomy position) yielded a threshold of \u0026gt;\u0026thinsp;40.08 kPa for identifying fistula tissue (preset threshold\u0026thinsp;=\u0026thinsp;0.45), whereas a measurement at the 5\u0026thinsp;~\u0026thinsp;7 o\u0026rsquo;clock position suggested fistula tissue at a threshold of \u0026gt;\u0026thinsp;54.95 kPa. For scar tissue, Young\u0026rsquo;s modulus was independent of measurement location, with values\u0026thinsp;\u0026gt;\u0026thinsp;104.34 kPa indicating fistula tissue.\u003c/p\u003e\u003ch2\u003eCONCLUSION\u003c/h2\u003e\u003cp\u003eShecar wave elastography shows potential for diagnosing anal fistulas, differentiating tissues of different types, and evaluating postoperative prognosis, enhancing diagnostic accuracy and providing a convenient tool for clinical assessment.\u003c/p\u003e","manuscriptTitle":"Shear Wave Elastography: Is the potential method in Assessing Anal Fistulas and Perianal Tissue strain？","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-19 23:36:47","doi":"10.21203/rs.3.rs-7896382/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"1b493d40-b89b-4a90-b2cc-ede3e72ef9da","owner":[],"postedDate":"November 19th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-03-10T22:38:15+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-19 23:36:47","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7896382","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7896382","identity":"rs-7896382","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}