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Endometriosis can cause infertility through four mechanisms, including inflammation and obstruction of the fallopian tubes, which impede fertilization.
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This chapter examines the idea that endometriosis is a cause of infertility by outlining four isolated or combined mechanisms, focusing in detail on inflammatory and obstructive pathways. It describes how early pelvic endometriotic implants trigger local and spreading inflammation, associated with dysmenorrhea and linked to the (total or partial) effectiveness of anti-inflammatory drugs for pain, while noting that an inflammatory genital environment—especially in the fallopian tubes—can impair fertilization even though this effect varies over time. It also explains how disease progression can lead to adhesions that obstruct the fallopian tubes either internally or via external compression/stricture, and that adhesions commonly form between the ovary and the tubal end. This paper is centrally about endometriosis — it reviews mechanisms (inflammatory and obstructive) by which endometriosis can contribute to infertility.
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