The Influence of Geographic Environmental Factors on the Distribution of Cholinesterase Reference Value in Healthy Chinese People

This paper screened the factors that may influence the distribution of Cholinesterase (CHE) reference value in healthy people in China, and explored the space distribution trend of CHE reference value in China. We collected the CHE of 17,633 healthy people in 172 cities and counties. Spearman regression analysis was used to analyze the correlation between CHE and 22 geography secondary indexes. We extracted 6 indexes with significant correlation, built a ridge regression model, and predicted the CHE reference value of countrys urban healthy people. By using the disjunctive Kriging method, we obtained the geographical distribution trend of CHE reference value of healthy people. The CHE reference value of healthy Chinese was significantly correlated with the 6 secondary indexes, namely, Latitude (°), Altitude(m), Annual average temperature (℃), Annual average relative humidity (%) and annual precipitation (mm),Topsoil sand gravel percentage(% wt).The geographical distribution of CHE reference value of healthy Chinese showed a trend of being high in the southeast and low in the northwest of China.This study lays a foundation for further research on the mechanism of different influencing factors on the reference value of CHE index. A ridge regression model composed of significant influencing factors has been established to provide the basis for formulating reference criteria for the treatment factors of the liver damage diseases and liver cancer using CHE reference value in different regions.