New-onset Diabetes Mellitus After Different Surgical Procedures for Pancreatic Malignant Tumors: A Comparative Study and Construction of a Diabetes Prediction Model

New-onset Diabetes Mellitus After Different Surgical Procedures for Pancreatic Malignant Tumors: A Comparative Study and Construction of a Diabetes Prediction Model | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article New-onset Diabetes Mellitus After Different Surgical Procedures for Pancreatic Malignant Tumors: A Comparative Study and Construction of a Diabetes Prediction Model Aorui Wang, Ruihan Hou, Chengxu Du, Weihong Zhao, Haitao Lv, Jingwei Wei, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-9129483/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 15 You are reading this latest preprint version Abstract Background Pancreatectomy is an invasive procedure. Postoperative new-onset diabetes mellitus (NODM) is a common metabolic complication. There are significant differences in the effects of different surgical types on the function of the pancreas.The study aimed to compare the impact of different surgical procedures on the incidence of new-onset diabetes mellitus and to construct a predictive model for NODM after pancreatic surgery in patients with malignant pancreatic tumors. Methods A retrospective analysis was conducted on data from patients who underwent pancreatic surgeries for malignant pancreatic tumors at the Second Hospital of Hebei Medical University between 2015 and 2025, including general characteristics, surgical type, intraoperative data and postoperative follow-up data. Independent risk factors for NODM were identified through logistic regression analysis, and a predictive model was constructed. The discrimination and calibration of the model were evaluated via ROC curves and calibration curves. Results A total of 376 patients were included. For patients who underwent pancreatoduodenectomy and duodenum-preserving pancreatic head resection (n = 189), the incidence of postoperative NODM (n = 34) was 18.0%. For patients who underwent distal pancreatectomy (n = 187), the incidence (n = 66) was 35.3%. There were significant differences between the two groups. Among the 50 patients who underwent open surgery, 15 (30.0%) developed NODM. Among the 326 patients who underwent laparoscopic surgery, 85 (26.1%) developed NODM. There was no significant difference between the laparoscopic group and the open group after inverse probability weighting. Multivariate analysis revealed that age (OR = 1.027, 95% CI: 1.006–1.048, P = 0.010), body mass index (OR = 1.197, 95% CI: 1.107–1.295, P < 0.001), preoperative glucose (OR = 2.212, 95% CI: 1.731–2.826, P < 0.001), and intraoperative blood loss (OR = 1.001, 95% CI: 1.001–1.001, P = 0.001) were independent risk factors for NODM. The model's C statistic was 0.877. Conclusion Pancreatic head resection (with or without resection of the duodenum) and distal pancreatic resection have different effects on the incidence of NODM. Compared with open surgery, laparoscopic surgery does not increase or decrease the incidence of NODM after pancreatic malignant tumor surgery. The predictive model for NODM after malignant pancreatic tumor surgery constructed in this study can assess the risk of postoperative NODM, providing support for clinical decision-making. pancreatic malignant tumor pancreatic surgeries new-onset diabetes mellitus predictive model laparoscope Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Reviews received at journal 11 May, 2026 Reviews received at journal 10 May, 2026 Reviews received at journal 02 May, 2026 Reviews received at journal 30 Apr, 2026 Reviews received at journal 29 Apr, 2026 Reviewers agreed at journal 27 Apr, 2026 Reviewers agreed at journal 26 Apr, 2026 Reviewers agreed at journal 25 Apr, 2026 Reviewers agreed at journal 25 Apr, 2026 Reviewers agreed at journal 24 Apr, 2026 Reviewers invited by journal 24 Apr, 2026 Editor assigned by journal 23 Apr, 2026 Editor invited by journal 02 Apr, 2026 Submission checks completed at journal 01 Apr, 2026 First submitted to journal 01 Apr, 2026 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9129483","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":634326983,"identity":"51357887-1eb7-490d-86a1-af4316ef8593","order_by":0,"name":"Aorui Wang","email":"","orcid":"","institution":"the Second Hospital of Hebei Medical University","correspondingAuthor":false,"prefix":"","firstName":"Aorui","middleName":"","lastName":"Wang","suffix":""},{"id":634326984,"identity":"9db25c52-d2b9-4a9a-9710-0de30a9032f1","order_by":1,"name":"Ruihan Hou","email":"","orcid":"","institution":"the Second Hospital of Hebei Medical 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Cancer","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"pancreatic malignant tumor, pancreatic surgeries, new-onset diabetes mellitus, predictive model, laparoscope","lastPublishedDoi":"10.21203/rs.3.rs-9129483/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-9129483/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003ePancreatectomy is an invasive procedure. Postoperative new-onset diabetes mellitus (NODM) is a common metabolic complication. There are significant differences in the effects of different surgical types on the function of the pancreas.The study aimed to compare the impact of different surgical procedures on the incidence of new-onset diabetes mellitus and to construct a predictive model for NODM after pancreatic surgery in patients with malignant pancreatic tumors.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eA retrospective analysis was conducted on data from patients who underwent pancreatic surgeries for malignant pancreatic tumors at the Second Hospital of Hebei Medical University between 2015 and 2025, including general characteristics, surgical type, intraoperative data and postoperative follow-up data. Independent risk factors for NODM were identified through logistic regression analysis, and a predictive model was constructed. The discrimination and calibration of the model were evaluated via ROC curves and calibration curves.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eA total of 376 patients were included. For patients who underwent pancreatoduodenectomy and duodenum-preserving pancreatic head resection (n\u0026thinsp;=\u0026thinsp;189), the incidence of postoperative NODM (n\u0026thinsp;=\u0026thinsp;34) was 18.0%. For patients who underwent distal pancreatectomy (n\u0026thinsp;=\u0026thinsp;187), the incidence (n\u0026thinsp;=\u0026thinsp;66) was 35.3%. There were significant differences between the two groups. Among the 50 patients who underwent open surgery, 15 (30.0%) developed NODM. Among the 326 patients who underwent laparoscopic surgery, 85 (26.1%) developed NODM. There was no significant difference between the laparoscopic group and the open group after inverse probability weighting. Multivariate analysis revealed that age (OR\u0026thinsp;=\u0026thinsp;1.027, 95% CI: 1.006\u0026ndash;1.048, \u003cem\u003eP\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.010), body mass index (OR\u0026thinsp;=\u0026thinsp;1.197, 95% CI: 1.107\u0026ndash;1.295, \u003cem\u003eP\u0026thinsp;\u0026lt;\u003c/em\u003e\u0026thinsp;0.001), preoperative glucose (OR\u0026thinsp;=\u0026thinsp;2.212, 95% CI: 1.731\u0026ndash;2.826, \u003cem\u003eP\u0026thinsp;\u0026lt;\u003c/em\u003e\u0026thinsp;0.001), and intraoperative blood loss (OR\u0026thinsp;=\u0026thinsp;1.001, 95% CI: 1.001\u0026ndash;1.001, \u003cem\u003eP\u0026thinsp;=\u003c/em\u003e\u0026thinsp;0.001) were independent risk factors for NODM. The model's C statistic was 0.877.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003ePancreatic head resection (with or without resection of the duodenum) and distal pancreatic resection have different effects on the incidence of NODM. Compared with open surgery, laparoscopic surgery does not increase or decrease the incidence of NODM after pancreatic malignant tumor surgery. The predictive model for NODM after malignant pancreatic tumor surgery constructed in this study can assess the risk of postoperative NODM, providing support for clinical decision-making.\u003c/p\u003e","manuscriptTitle":"New-onset Diabetes Mellitus After Different Surgical Procedures for Pancreatic Malignant Tumors: A Comparative Study and Construction of a Diabetes Prediction Model","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-05-05 17:00:59","doi":"10.21203/rs.3.rs-9129483/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2026-05-11T06:37:53+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-10T12:57:12+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-02T21:26:05+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-01T01:44:03+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-04-29T22:50:03+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"173638236592018260595831825022791197538","date":"2026-04-27T13:04:48+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"161838805706193322472080214551161008657","date":"2026-04-26T12:19:38+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"222632133985741199948943619761641336550","date":"2026-04-25T17:05:04+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"164295004233091735657480037206284441501","date":"2026-04-25T07:58:42+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"195923128134370555006975947816227418834","date":"2026-04-24T21:20:34+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2026-04-24T17:47:11+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2026-04-23T07:26:34+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2026-04-02T09:55:15+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2026-04-01T15:45:04+00:00","index":"","fulltext":""},{"type":"submitted","content":"BMC Cancer","date":"2026-04-01T13:29:15+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-cancer","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"bcan","sideBox":"Learn more about [BMC Cancer](http://bmccancer.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/bcan/default.aspx","title":"BMC Cancer","twitterHandle":"BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"66cfeba7-216c-4c9c-8bdc-4cf4d02cb7b8","owner":[],"postedDate":"May 5th, 2026","published":true,"recentEditorialEvents":[{"type":"editorInvitedReview","content":"","date":"2026-05-11T06:37:53+00:00","index":63,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-10T12:57:12+00:00","index":62,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-02T21:26:05+00:00","index":61,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-05-01T01:44:03+00:00","index":60,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-04-29T22:50:03+00:00","index":59,"fulltext":""}],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-05-05T17:00:59+00:00","versionOfRecord":[],"versionCreatedAt":"2026-05-05 17:00:59","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-9129483","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-9129483","identity":"rs-9129483","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}