The role of an interdisciplinary approach to the treatment of patients with reduced ovarian reserve, premature ovarian insufficiency and mood disorders

Yu. S. Absatarova, Yu. S. Evseeva, T. A. Zelenkova-Zakharchuk, Е. Н. Андреева, E. V. Sheremetyeva, O. R. Grigoryan
In: Problems of Endocrinology · 2025 · vol. 71(3) , pp. 68–74 · doi:10.14341/probl13576 · PMID:40734303 · W4412628402
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Abstract

Diminished ovarian reserve and premature ovarian insufficiency (POI) are the pathologies associated with poor reproductive prognosis, decreased estrogen production, and the development of multiple complications of hypoestrogenism. Currently, in the absence of a response to superovulation stimulation, the most likely way for patients with these conditions to achieve pregnancy is through the use of a donor oocyte. In addition, the condition of the patient presented in the second clinical description is aggravated the pathology of carbohydrate metabolism. However, the management of these women often overlooks their mental exhausting which exacerbates the underlying condition. In this publication, we present descriptions of patients with diminished ovarian reserve and POI with concomitant mood disorders who wish to become pregnant. Both patients were treated under dynamic monitoring by a psychotherapist with positive results. Moreover, spontaneous pregnancy occurred in both women described in this article. These clinical cases highlight the importance of a multidisciplinary approach in managing women with ovarian insufficiency to enhance treatment effectiveness and restore reproductive function.

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