Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak

Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak chune zhu, Xiangyan Wang, Youpeng Qi, Baohong Mi, Changze Cui, and 8 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3893649/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Acetyl-CoA carboxylase beta (ACACB) is a rate-limiting enzyme involved in lipid syn-thesis and fatty acid oxidation. The results of our previous study showed that a total of seven SNPs were detected in the exon 37-intron 37, exon 46-intron 46, and intron 47 regions of the yak ACACB, and mutations in the ACACB were found to affect yak meat quality traits. However, the genetic effects of ACACB on yak milk quality traits have not been reported. Therefore, the aim of this study was to investigate the effects of ACACB polymorphisms on yak milk quality traits in Gannan yaks. In this study, A total of 202 Gannan yaks were included in the study. Analyze the different geno-types, diplotypes, and the presence or absence of haplotypes on milk quality. The seven SNPs were named as exon 37-intron 37 (exon 37: SNP1, intron 37: SNP2 and SNP3), exon 46-intron 46 (exon 46: SNP4, intron 46: SNP5), and intron 47 (SNP6 and SNP7). Apart from the SNP1, SNP2, SNP5, and SNP6 loci where the polymorphic information content (PIC) was low (PIC ≤ 0.25), the SNP3, SNP4, and SNP7 loci were all of intermediate polymorphic information status (0.25 < PIC < 0.5). The highest frequency of heterozygosity occurred at the SNP7 locus, and the two alleles were evenly distributed in the population compared to alleles at the other loci. There were no strong linkages between the SNPs (r 2 <0.33) except for a strong linkage disequilibrium observed between SNP1 and SNP2 (r 2 =0.89). Seven effective haplotypes and seven diplotypes were constructed for the Gannan yak ACACB gene. Correlation analysis showed that SNP1 and SNP7 were associated with lactose content ( P <0.05), while SNP3 was significantly associated with the protein and monounsaturated fatty acid contents in the milk ( P <0.05). SNP4 was significantly associated with both saturated and monounsaturated fatty acid contents ( P <0.05 and P <0.01, respectively), while SNPs 5 and 7 were significantly correlated with the fat percentage ( P <0.05) and SNP6 was significantly correlated with total solid content of the milk ( P <0.05). Yaks with the H2H2 diplotype had significantly higher levels of milk fat than other diplotypes ( P <0.05) while milk fat contents in animals carrying hap-lotype H2 were significantly higher than that in yaks carrying the deletion type ( P <0.05). The findings of the present study suggest that polymorphisms in the yak ACACB affect milk quality and can be used as genetic markers for enhancing milk quality in yak populations. The findings provide a theoretical basis for the genetic characterization of milk quality traits in the Gannan yak. Biological sciences/Biological techniques Biological sciences/Genetics Biological sciences/Molecular biology Figures Figure 1 Figure 2 Introduction The yak, Bos grunniens , is the largest ruminant unique to the Tibetan Plateau and its neighboring high-altitude regions, where it can survive in the harsh environmental conditions, including low oxygen levels 1 . The yak provides products such as meat, milk, wool, and fleece, as well as animal power, fuel, and transportation, for local herders 2 and is thus an indispensable livestock species in the local economy. Yak milk is thick, sweet, and rich in nutrients, and is known as "natural concentrated milk". The milk also contains higher levels of dry matter, protein, fatty acids, minerals, and other nutrients than cow’s milk, and yak milk is also rich in vitamins A and C, has significant antioxidant properties, and is one of the best raw milks for the processing of cream products 3 . Yak milk is rich in protein, with a protein fraction of 5.32% 4 and enhances the gastrointestinal immune function, absorption of calcium and phosphorus absorption, and has significant potential for the development of infant milk products 5 . It is known that milk production in mammals such as cows is affected by factors such as the genetics, breed, and nutritional level of the animal, as well as the calving litter size, calving age, and lactation season. Genetic studies of milk production have mainly focused on improving the yield and protein and fat contents of the mill. Milk fat is mainly composed of triglycerides and small amounts of cholesterol, diglycerides, monoglycerides, and free fatty acids, mostly short-chain saturated fatty acids (SFAs) together with phospholipids, sterols, pigments, and fat-soluble vitamins, all of which are easy for the body to digest and absorb. Furthermore, milk fat has an aromatic odor and is an important source of flavor in dairy products. Therefore, the percentage of milk represents a key indicator of the nutritional value of the milk, and reflects the production performance of dairy cows with economic consequences. In this study, we analyzed candidate genes associated with milk fat traits in the yak and investigated the effects of genetic mutation on milk quality. Genes associated with milk fats are mostly associated with fatty acid and triglyceride synthesis. Lactation is regulated by multiple genes. For example, polymorphisms in exon 1 G>C and exon 34 A>G of the fatty acid synthase FASN gene are associated with milk fat content in Chinese Holstein cows 6 . While polymorphisms in signal transducer and activator of transcription 5A ( STAT5A ) influence both milk yield and fat percentage 7 and polymorphisms in fatty acid-binding protein 3 ( FABP3 ) were found to be significantly correlated with milk fat traits in Mehsana buffaloes 8 . Acetyl-coenzyme A carboxylase (ACC) was discovered in the late 1950s by Salih et al. It is a biotin-dependent carboxylase, belonging to the intermolecular carboxylation transfer family, which catalyzes the carboxylation of acetyl-coenzyme A to malonyl-monoacyl-coenzyme A during fatty acid synthesis and metabolism. ACC consists of two isomers, α and β, and plays a major regulatory role in the regulation of fatty acid metabolism 9,10 . Acetyl-CoA carboxylase beta is encoded by the acetyl-CoA carboxylase beta gene ( ACACB ). The protein is localized outside the mitochondria and regulates the activity of carnitine palmitoyltransferase1 (CPT-1), preventing the transport of fatty acids into the mitochondria for fatty acid beta-oxidation 11 . It is a rate-limiting enzyme that promotes lipid synthesis and plays a key regulatory role in lipid metabolism. Studies have shown that the ACACB gene is located in a quantitative trait locus (QTL) region known to significantly influence fat yield 12,13 . Much of the current research on ACACB has focused on diseases such as cancer and obesity in humans and mice. The ACACB protein is abundantly expressed in skeletal and cardiac muscle 14-17 , as well as in the liver, and is also found in mammalian brown adipose tissue, mammary glands, and pancreatic islets 11,17 . Common polymorphisms in ACACB are associated with diseases such as obesity. Harwood et al. found that persistent fatty acid oxidation in adipocytes in ACACB -knockout mice protects against obesity and diabetes and is accompanied by reductions in abdominal fat stores 18,19 . Han et al. showed that single nucleotide polymorphisms (SNPs) in ACACB in Chinese Holstein cows were significantly correlated with the overall yield, fat yield, fat percentage, protein yield, and protein percentage in the milk 20 . Currently, genetic breeding is an important initiative to improve milk production in yaks. However, most studies on ACACB have focused on its role in cancer and obesity-related diseases, with only a few studies focusing on animal production traits. In the present study, polymorphisms in the key ACACB gene were investigated in a population of Gannan yaks, with the aim of assessing the effects of ACACB genetic variation and its haplotypes on milk quality traits, and provide a theoretical basis for genetic breeding to enhance the butterfat content of the milk to improve the quality of milk-based products. Results 1. ACACB PCR Products As shown by analysis of 1.5% agarose gels (Figure 1) it can be seen that the amplification products in the lanes are clear and bright with good specificity. Three bands at 455 bp, 362 bp, and 790 bp were observed. 2. Genetic Characterization of SNPs in ACACB The results of our previous study showed that seven SNPs were detected in three regions of ACACB and each SNP had three genotypes 21 . The results of the genotype frequency, allele frequency, and population genetic polymorphism analyses of the SNPs are shown in Table 1. The dominant genotypes of the SNP1, SNP2, SNP3, SNP4, SNP5, SNP6, and SNP7 loci were GG, CC, GC, CC, CC, GG, and GA, respectively; the PIC contents were all of moderate polymorphic information status (0.25<PIC<0.5), and the SNP1, SNP2, SNP5, and SNP6 loci showed low polymorphism (PIC≤0.25), indicating that the three SNP loci, SNP3, SNP4, and SNP7, had high genetic variance and strong selection potentials. The heterozygosity results showed the highest frequency at the SNP7 locus, and the number of effective alleles showed that the two alleles at the SNP7 locus were evenly distributed in the population compared with those at the other loci. Table 1. Analysis of genetic polymorphism in yak ACACB . SNPs Genotype Frequency/% Allele Frequency/% PIC He Ho Ne SNP1 AA（6） 2.97 GA（30） 14.85 GG（166） 82.18 A 10.40 G 89.61 0.1690 0.1863 0.8137 1.2290 SNP2 AA（2） 0.99 CA（34）16.83 CC（166） 82.18 A 9.41 C 90.60 0.1559 0.1704 0.8296 1.2054 SNP3 CC（71） 35.15 GC（91） 45.05 GG（40） 19.80 C 57.68 G 42.32 0.3690 0.4882 0.5118 1.9540 SNP4 CC（129） 63.86 CT（63） 31.19 TT（10） 4.95 C 79.46 T 20.54 0.2732 0.3265 0.6735 1.4847 SNP5 CC（149） 73.76 CT（49） 24.26 TT（4） 1.98 C 85.89 T 24.11 0.2130 0.2424 0.7576 1.3199 SNP6 AA（6） 2.97 GA（57） 28.22 GG（139） 68.81 A 17.08 G 82.92 0.2431 0.2832 0.7168 1.3952 SNP7 AA（46） 22.77 GA（97） 48.02 GG（59） 29.21 A 46.78 G 53.22 0.3740 0.4979 0.5021 1.9918 3. Linkage Disequilibrium and Haplotype Analysis of SNPs The results of the linkage disequilibrium analysis of the loci of the seven SNPs in ACACB are shown in Figure 2. Strong linkage disequilibrium was seen between SNP1 and SNP2 (r 2 =0.89), while no strong linkage was observed between the other SNPs (r 2 <0.33). The results of haplotype analysis are shown in Table 2; excluding haplotypes with frequencies lower than 3% in the Gannan yak population, a total of seven haplotypes with frequencies greater than 3% were detected, of which, haplotype H2 had the highest frequency of 29.20%, followed by 19.50% for H3, and 14.60% for H4, while H1, H5, H6, and H7 had lower frequencies of 7.10%, 9.40%, 3.40% and 3.90% respectively. A total of 28 diplotypes were found for the seven haplotypes. After exclusion of diplotypes with frequencies lower than 5%, seven were identified, namely, H1H2, H2H2, H2H3, H2H4, H2H5, H3H3, and H3H4, with the frequencies of 5.23, 14.38, 9.15, 11.76, 7.19, 6.54, and 9.15%, respectively. The values of r 2 represent coefficient of LD between two sites, r 2 > 0.33 indicates a strong LD between sites. Table 2. Haplotype analysis of ACACB mutation sites in yak. Haplotype Mutation site Frequency/% diplotypes Frequency/% SNP1 SNP2 SNP3 SNP4 SNP5 SNP6 SNP7 H1 G C G C T G A 7.10 H1H2 5.23 H2 G C C C C G G 29.20 H2H2 14.38 H3 G C C T C G A 19.50 H2H3 9.15 H4 G C G C C A G 14.60 H2H4 11.76 H5 A A G C C G A 9.40 H2H5 7.19 H6 G C G C C G G 3.40 H3H3 6.54 H7 G C G C C G A 3.90 H3H4 9.15 4. Analysis of the Correlation between ACACB Genotype and Milk Quality traits in Gannan Yak The association analysis of ACACB genotypes with milk quality traits in Gannan yaks is shown in Table 3. The results indicate that the lactose contents of milk from individual yaks of the AA genotype at the SNP1 locus were significantly higher than those present in the GG genotype ( P <0.05). The milk protein contents in yaks with the GC genotype at the SNP3 locus were significantly higher than those with the GG genotype ( P <0.05), while the levels of milk fat associated with the CC genotype at the SNP5 locus were markedly greater than those of the TT genotype ( P <0.05). The total solid contents in the milk from individual yaks of the GG genotype at the SNP6 locus were significantly greater than those of the GA genotype ( P <0.05), while the milk fat levels in yaks of the GG genotype at the SNP7 locus were markedly increased in comparison with yaks of the GA genotype and lactose levels in yaks with the AA genotype were significantly higher than those with the and the GG genotype ( P 0.05). The results indicated that the genotypes at the SNP loci in the ACACB gene were significantly associated with milk quality traits, suggesting their potential use as genetic markers for milk quality improvement in Gannan yaks. Table 3. Correlations between ACACB genotypes and milk quality traits in Gannan yak. SNPs Genetypes Milk quality No. Protein rate/% P -value Fat rate/% P -value Lactose rate/% P -value Total solids/% P -value Non-fat solids/% P -value SNP1 AA 6 4.94±0.34 0.923 5.08±0.67 0.880 5.27±0.20 a 0.043 16.44±1.18 0.688 11.46±0.55 0.924 GA 30 5.07±0.17 4.82±0.33 4.92±0.10 ab 16.44±0.59 11.37±0.27 GG 166 5.02±0.10 4.97±0.20 4.82±0.06 b 16.00±0.35 11.29±0.16 SNP2 AA 2 4.80±0.58 0.896 5.86±1.12 0.612 5.18±0.33 0.213 17.16±2.00 0.641 11.22±0.93 0.921 CA 34 5.06±0.16 4.81±0.32 4.93±0.09 16.40±0.56 11.39±0.26 CC 166 5.02±0.10 4.97±0.20 4.81±0.06 16.00±0.35 11.29±0.16 SNP3 CC 71 4.98±0.13 ab 0.047 5.15±0.25 0.326 4.82±0.08 0.173 16.47±0.45 0.191 11.27±0.21 0.247 GC 91 5.17±0.12 a 4.79±0.23 4.78±0.07 16.11±0.40 11.46±0.19 GG 40 4.81±0.15 b 5.02±0.25 4.94±0.08 15.50±0.51 11.06±0.23 SNP4 CC 129 5.02±0.11 0.424 5.00±0.21 0.584 4.83±0.06 0.066 16.19±0.37 0.552 11.30±0.17 0.306 CT 63 5.00±0.13 4.90±0.26 4.74±0.08 15.73±0.46 11.24±0.21 TT 10 5.35±0.27 4.49±0.52 5.10±0.15 16.23±0.93 11.91±0.43 SNP5 CC 149 5.09±0.11 0.263 5.13±0.21 a 0.045 4.81±0.06 0.870 16.23±0.37 0.212 11.39±0.17 0.448 CT 49 4.97±0.15 4.79±0.28 ab 4.79±0.09 16.21±0.51 11.19±0.23 TT 4 4.48±0.41 3.36±0.78 b 4.91±0.23 13.67±1.40 10.76±0.65 SNP6 AA 6 5.00±0.11 0.212 5.71±0.67 0.492 4.78±0.20 0.353 16.19±0.38 ab 0.042 11.13±0.54 0.207 GA 57 4.88±0.13 4.91±0.25 4.75±0.08 15.34±0.44 b 11.09±0.21 GG 139 5.11±0.11 4.94±0.21 4.85±0.06 16.45±0.38 a 11.44±0.17 SNP7 AA 46 5.04±0.14 0.383 4.74±0.27 bc 0.040 4.93±0.08 a 0.040 16.08±0.49 0.792 11.43±0.23 0.433 GA 97 4.95±0.12 4.81±0.22 b 4.82±0.07 ab 15.94±0.40 11.18±0.19 GG 59 5.14±0.13 5.39±0.26 a 4.70±0.08 b 16.26±0.46 11.41±0.21 Data are shown as Mean ± SE; different lowercase letters in the same column indicate significant differences ( P <0.05). 5. Effects of ACACB Genotype on Different Fatty acid Contents The effects of ACACB genotypes of Gannan yak on the contents of different kinds of fatty acids are shown in Tables 4-8. The results showed that different genotypes at different SNP loci affected the levels of various types of fatty acids. Specifically, the C20:3n8C contents in individual yaks of the AA genotype at the SNP1 locus were significantly higher than that of the GG and GA genotypes ( P <0.05), and the C11:0, C18:0, and C20:3n8C contents in yaks with the AA genotype at the SNP2 locus was significantly greater than those of the CC and CA genotypes ( P <0.05 and P <0.01, respectively). C11:0, C18:0, and C20:3n8C were also markedly increased compared with the CC and CA genotypes ( P <0.05 and P <0.01, respectively) while C14:0 and C16:0 were significantly higher in yaks with the GC genotype compared with the CC genotype at the SNP3 locus ( P <0.05), and C23:0 was significantly higher than in the GG genotype in yak individuals of both GC and CC genotypes ( P <0.05). In terms of monounsaturated fatty acids (MUFAs), the MUFA levels were significantly higher in the CC genotype compared with the GC and GG genotypes ( P =0.05) while the C10:0, C14:0, C16:0, and SFA contents in SNP4 locus/CC and CT genotype yak individuals were significantly greater than those of the TT genotype ( P <0.05, P <0.01) and the TT genotype was associated with markedly higher ( P <0.05, P <0.01) levels of C17:1C, C18:1C, C18:3n6, and MUFA than the CC and CT genotypes. The SNP5 locus/CT genotype yak individuals had significantly ( P <0.05) higher levels of C16:0 and C18:0 than those with the CC and TT genotypes, while genotypes associated with the SNP6 and SNP7 loci showed no significant associations with the levels of different types of fatty acids ( P >0.05). The results indicated that the genotypes at the SNP loci of the Gannan yak ACACB gene that were significantly or highly significantly associated with the contents of different types of fatty acids could be used as markers for the improvement of the fatty acid contents of Gannan yak milk. Table 4. Correlations between ACACB genotypes and contents of different fatty acids in Gannan yak. SNPs Genetypes Fatty acid (%) No. C4:0 P C6:0 P C8:0 P C10:0 P C11:0 P C12:0 P C13:0 P C14:0 P C14:1C P SNP1 AA 6 1.24±0.22 0.611 1.86±0.34 0.390 1.08±0.22 0.529 2.02±0.33 0.623 0.39±0.18 0.606 1.48±0.26 0.870 0.28±0.07 0.682 7.31±0.76 0.709 0.67±0.17 0.443 GA 30 1.41±0.11 2.34±0.17 1.33±0.11 2.36±0.17 0.21±0.09 1.63±0.13 0.23±0.04 7.96±0.38 0.60±0.09 GG 166 1.32±0.07 2.20±0.10 1.27±0.06 2.29±0.10 0.21±0.05 1.62±0.08 0.22±0.02 7.88±0.23 0.52±0.05 SNP2 AA 2 0.99±0.37 0.433 1.22±0.57 0.157 0.64±0.36 0.168 1.11±0.56 0.083 1.03±0.30 a 0.026 1.05±0.44 0.432 0.12±0.12 0.535 5.35±1.27 0.122 0.53±0.29 0.451 CA 34 1.41±0.10 2.32±0.16 1.33±0.10 2.37±0.16 0.20±0.09 b 1.63±0.13 0.24±0.03 7.99±0.36 0.62±0.08 CC 166 1.32±0.07 2.20±0.10 1.27±0.06 2.29±0.10 0.22±0.05 b 1.61±0.08 0.22±0.02 7.87±0.22 0.52±0.05 SNP3 CC 71 1.29±0.08 0.686 2.06±0.13 0.125 1.22±0.08 0.193 2.18±0.13 0.323 0.28±0.07 0.147 1.64±0.10 0.906 0.20±0.03 0.249 7.41±0.28 b 0.010 0.48±0.07 0.059 GC 91 1.36±0.08 2.32±0.12 1.35±0.07 2.37±0.11 0.15±0.06 1.61±0.09 0.22±0.02 8.25±0.25 a 0.61±0.06 GG 40 1.33±0.10 2.21±0.15 1.22±0.09 2.29±0.14 0.26±0.08 1.58±0.11 0.26±0.03 7.73±0.32 ab 0.46±0.07 SNP4 CC 129 1.35±0.07 0.315 2.26±0.11 0.136 1.30±0.07 0.219 2.34±0.10 a 0.043 0.22±0.06 0.430 1.65±0.08 0.368 0.24±0.02 0.387 7.94±0.23 a 0.000 0.53±0.05 0.682 CT 63 1.31±0.09 2.16±0.13 1.26±0.08 2.25±0.13 a 0.20±0.07 1.57±0.10 0.20±0.03 8.03±0.28 a 0.56±0.07 TT 10 1.10±0.17 1.75±0.27 1.01±0.17 1.71±0.26 b 0.39±0.14 1.39±0.21 0.20±0.06 5.54±0.57 b 0.44±0.14 SNP5 CC 149 1.24±0.22 0.060 2.17±0.11 0.183 1.26±0.07 0.428 2.25±0.10 0.439 0.24±0.06 0.293 1.60±0.08 0.487 0.22±0.02 0.977 7.78±0.23 0.055 0.55±0.05 0.376 CT 49 1.41±0.11 2.13±0.15 1.24±0.09 2.36±0.14 0.14±0.08 1.55±0.11 0.23±0.03 8.45±0.32 0.57±0.07 TT 4 1.32±0.07 2.93±0.40 1.60±0.25 2.65±0.39 0.14±0.22 1.94±0.31 0.22±0.09 7.29±0.89 0.27±0.20 SNP6 AA 6 1.41±0.22 0.556 2.55±0.34 0.356 1.05±0.22 0.517 2.24±0.33 0.692 0.38±0.18 0.658 1.59±0.26 0.577 0.30±0.07 0.413 7.61±0.76 0.890 0.53±0.17 0.949 GA 57 1.27±0.08 2.11±0.13 1.27±0.08 2.23±0.13 0.21±0.07 1.55±0.10 0.23±0.03 7.95±0.29 0.55±0.07 GG 139 1.36±0.07 2.25±0.11 1.29±0.07 2.33±0.11 0.21±0.06 1.65±0.08 0.22±0.02 7.85±0.24 0.53±0.06 SNP7 AA 46 1.24±0.09 0.367 2.04±0.14 0.221 1.20±0.09 0.297 2.15±0.14 0.238 0.28±0.08 0.406 1.48±0.11 0.143 0.23±0.03 0.497 7.37±0.31 0.061 0.53±0.07 0.997 GA 97 1.37±0.07 2.28±0.12 1.33±0.07 2.39±0.11 0.18±0.06 1.70±0.09 0.21±0.02 8.12±0.25 0.54±0.06 GG 59 1.35±0.09 2.25±0.13 1.24±0.08 2.26±0.13 0.24±0.07 1.59±0.10 0.24±0.03 7.90±0.29 0.53±0.07 Data in shown as “Mean ± SE”; Data in the same column with different lowercase letters on the shoulders indicate significant differences ( P <0.05). Table 5. Correlations between ACACB genotypes and contents of different fatty acids in Gannan yak. SNPs Genetypes Fatty acid (%) No. C15:0 P C15:1C P C16:0 P C16:1C P C17:0 P C17:1C P C18:0 P C18:1T P C18:1C P SNP1 AA 6 0.90±0.26 0.667 0.33±0.13 0.683 28.85±2.92 0.731 0.62±0.23 0.206 0.89±0.18 0.316 0.28±0.51 0.793 24.82±2.55 0.308 1.75±0.59 0.584 17.50±3.12 0.321 GA 30 1.03±0.13 0.21±0.07 31.01±1.46 0.87±0.12 0.99±0.09 0.46±0.25 23.72±1.27 1.11±0.29 15.79±1.55 GG 166 1.09±0.08 1.09±0.08 30.18±0.87 0.98±0.07 0.86±0.05 0.56±0.15 22.27±0.76 1.20±0.18 17.99±0.93 SNP2 AA 2 0.11±0.44 0.080 0.37±0.22 0.779 23.26±4.92 0.277 0.30±0.40 0.130 0.92±0.30 0.356 0.18±0.86 0.800 38.40±4.17 a 0.001 0.69±1.00 0.864 15.39±5.28 0.364 CA 34 1.06±0.12 0.22±0.06 31.06±1.39 0.86±0.11 0.97±0.08 0.46±0.24 23.11±1.18 b 1.24±0.28 16.10±1.49 CC 166 1.09±0.08 0.21±0.04 30.16±0.87 0.98±0.07 0.86±0.05 0.56±0.15 22.32±0.74 b 1.19±0.18 17.98±0.93 SNP3 CC 71 1.07±0.10 0.868 0.22±0.05 0.998 28.25±1.10 b 0.018 0.94±0.09 0.192 0.87±0.07 0.845 0.83±0.19 0.070 23.36±0.97 0.400 1.26±0.23 0.887 19.11±1.19 0.180 GC 91 1.07±0.09 0.22±0.05 30.89±0.98 a 1.03±0.08 0.87±0.06 0.45±0.17 22.28±0.87 1.15±0.20 17.03±1.07 GG 40 1.13±0.11 0.21±0.06 31.54±1.24 a 0.84±0.10 0.91±0.07 0.36±0.22 21.92±1.10 1.20±0.26 17.22±1.34 SNP4 CC 129 1.12±0.08 0.518 0.21±0.04 0.674 30.50±0.89 a 0.025 0.97±0.07 0.822 0.88±0.05 0.093 0.46±0.16 b 0.024 22.40±0.80 0.630 1.21±0.18 0.988 17.28±0.93 b 0.000 CT 63 1.02±0.10 0.23±0.05 30.43±1.11 a 0.95±0.09 0.85±0.07 0.63±0.19 b 22.95±0.99 1.18±0.23 17.44±1.16 b TT 10 0.98±0.21 0.29±0.11 24.46±2.27 b 0.85±0.19 1.15±0.14 1.49±0.39 a 21.11±2.02 1.22±0.47 27.53±2.36 a SNP5 CC 149 1.05±0.08 0.565 0.22±0.04 0.938 29.58±0.90 b 0.038 0.99±0.07 0.445 0.87±0.06 0.242 0.61±0.16 0.244 23.13±0.79 a 0.046 1.08±0.18 0.175 17.89±0.98 0.794 CT 49 1.11±0.11 0.20±0.06 32.44±1.24 a 0.90±0.10 0.81±0.08 0.28±0.22 20.76±1.09 b 1.26±0.25 17.74±1.35 TT 4 1.36±0.31 0.24±0.16 31.44±3.42 ab 0.74±0.28 1.18±0.21 0.61±0.60 20.81±2.99 b 2.34±0.70 15.28±3.72 SNP6 AA 6 0.88±0.26 0.625 0.21±0.13 0.870 29.00±2.93 0.594 0.64±0.24 0.221 0.83±0.18 0.824 0.61±0.51 0.775 24.07±2.56 0.654 0.98±0.59 0.218 16.63±3.15 0.927 GA 57 1.13±0.10 0.23±0.05 30.97±1.11 1.03±0.09 0.86±0.07 0.45±0.19 22.03±0.97 0.97±0.22 17.87±1.20 GG 139 1.07±0.08 0.21±0.04 29.94±0.94 0.93±0.08 0.89±0.06 0.59±0.16 22.70±0.82 1.34±0.19 17.65±1.01 SNP7 AA 46 1.03±0.11 0.821 0.24±0.06 0.551 29.81±1.22 0.816 0.90±0.09 0.284 0.97±0.07 0.109 0.62±0.21 0.831 22.28±1.06 0.533 1.37±0.25 0.606 19.21±1.29 0.086 GA 97 1.10±0.09 0.23±0.05 30.57±0.99 0.93±0.08 0.88±0.06 0.54±0.17 22.99±0.87 1.16±0.20 16.52±1.05 GG 59 1.09±0.10 0.18±0.05 30.13±1.15 1.05±0.09 0.80±0.07 0.48±0.20 21.91±1.00 1.12±0.23 18.37±1.22 Data in shown as “Mean ± SE”; Data in the same column with different lowercase letters on the shoulders indicate significant differences ( P <0.05). Table 6. Correlations between ACACB genotypes and contents of different fatty acids in Gannan yak. SNPs Genetypes Fatty acid (%) No. C18:2T P C18:2C P C20:0 P C18:3n6 P C20:1C P C18:3n9 P C21:0 P C20:2C P C22:0 P SNP1 AA 6 0.64±0.18 0.815 1.17±0.26 0.844 0.56±0.10 0.565 0.41±0.20 0.380 0.98±0.35 0.524 0.83±0.31 0.832 1.21±0.35 0.926 0.23±0.10 0.579 0.27±0.14 0.647 GA 30 0.58±0.09 1.20±0.13 0.61±0.05 0.13±0.10 0.68±0.18 1.03±0.15 1.15±0.18 0.23±0.05 0.14±0.07 GG 166 0.54±0.06 1.26±0.08 0.55±0.03 0.23±0.06 0.86±0.11 1.00±0.09 1.21±0.11 0.28±0.03 0.19±0.04 SNP2 AA 2 0.86±0.31 0.568 0.75±0.44 0.492 0.60±0.17 0.608 0.41±0.35 0.683 0.80±0.60 0.706 0.31±0.52 0.399 0.90±0.60 0.524 0.30±0.18 0.537 0.53±0.24 0.262 CA 34 0.57±0.09 1.22±0.12 0.60±0.05 0.17±0.10 0.73±0.17 1.03±0.15 1.17±0.17 0.23±0.05 0.14±0.07 CC 166 0.54±0.06 1.25±0.08 0.55±0.03 0.23±0.06 0.80±0.60 1.00±0.09 1.21±0.11 0.28±0.03 0.19±0.43 SNP3 CC 71 0.52±0.07 0.747 1.29±0.11 0.561 0.54±0.04 0.676 0.26±0.08 0.525 0.97±0.13 0.068 1.02±0.12 0.327 1.15±0.13 0.287 0.31±0.04 0.356 0.24±0.06 0.137 GC 91 0.57±0.06 1.20±0.09 0.57±0.04 0.18±0.07 0.88±0.12 0.92±0.11 1.14±0.12 0.27±0.04 0.14±0.05 GG 40 0.54±0.08 1.29±0.10 0.57±0.04 0.24±0.09 0.59±0.15 1.12±0.13 1.38±0.15 0.24±0.05 0.22±0.06 SNP4 CC 129 0.53±0.06 0.441 1.30±0.04 0.154 0.57±0.03 0.817 0.21±0.06 b 0.043 0.77±0.11 0.074 1.05±0.10 0.252 1.27±0.11 0.284 0.28±0.03 0.782 0.18±0.05 0.919 CT 63 0.58±0.07 1.15±0.10 0.55±0.04 0.19±0.08 b 0.93±0.14 0.90±0.12 1.07±0.14 0.27±0.04 0.19±0.06 TT 10 0.68±0.14 1.02±0.20 0.55±0.08 0.59±0.16 a 1.35±0.28 0.78±0.24 1.11±0.28 0.22±0.08 0.23±0.11 SNP5 CC 149 0.55±0.06 0.243 1.23±0.08 0.836 0.55±0.03 0.296 0.22±0.06 0.825 0.88±0.11 0.600 0.99±0.10 0.909 1.18±0.11 0.742 0.29±0.03 0.173 0.21±0.05 0.189 CT 49 0.47±0.08 1.27±0.11 0.54±0.04 0.18±0.09 0.76±0.15 1.00±0.13 1.29±0.15 0.22±0.04 0.11±0.06 TT 4 0.83±0.22 1.37±0.31 0.74±0.12 0.32±0.24 0.62±0.42 1.15±0.37 1.20±0.42 0.19±0.12 0.16±0.17 SNP6 AA 6 0.61±0.18 0.580 1.03±0.26 0.677 0.58±0.10 0.964 0.33±0.21 0.849 0.42±0.35 0.413 1.24±0.31 0.722 1.60±0.35 0.503 0.28±0.11 0.994 0.35±0.15 0.514 GA 57 0.59±0.07 1.25±0.10 0.56±0.04 0.22±0.08 0.90±0.14 0.98±0.12 1.17±0.13 0.27±0.04 0.18±0.06 GG 139 0.61±0.18 1.25±0.08 0.56±0.03 0.21±0.07 0.83±0.11 1.24±0.31 1.20±0.11 0.27±0.03 0.19±0.05 SNP7 AA 46 0.61±0.08 0.585 1.17±0.11 0.606 0.56±0.04 0.888 0.29±0.09 0.449 0.81±0.15 0.633 0.92±0.13 0.607 1.18±0.15 0.875 0.24±0.04 0.445 0.21±0.06 0.669 GA 97 0.54±0.06 1.26±0.09 0.57±0.04 0.18±0.07 0.89±0.12 1.01±0.11 1.19±0.12 0.29±0.04 0.17±0.05 GG 59 0.52±0.07 1.29±0.10 0.55±0.04 0.21±0.08 0.77±0.14 1.06±0.12 1.25±0.14 0.27±0.04 0.20±0.06 Data in shown as “Mean ± SE”; Data in the same column with different lowercase letters on the shoulders indicate significant differences ( P <0.05). Table 7. Correlations between ACACB genotypes and and contents of different fatty acids in Gannan yak. SNPs Genetypes Fatty acid (%) No. C20:3n8C P C22:1C P C20:4C P C23:0 P C22:2C P C24:0 P C20:5C P C24:1C P SNP1 AA 6 0.35±0.11 a 0.028 0.23±0.09 0.785 0.06±0.05 0.696 0.36±0.12 0.358 0.07±0.05 0.508 0.10±0.05 0.786 0.21±0.05 0.720 0.04±0.02 0.954 GA 30 0.08±0.06 b 0.16±0.05 0.22±0.09 0.23±0.06 0.02±0.02 0.10±0.03 0.16±0.03 0.03±0.01 GG 166 0.05±0.03 b 0.18±0.03 0.20±0.05 0.20±0.04 0.04±0.01 0.12±0.02 0.17±0.02 0.03±0.01 SNP2 AA 2 0.99±0.18 a 0.000 0.35±0.15 0.454 0.05±0.30 0.878 0.86±0.21 0.006 0.17±0.08 0.132 0.14±0.09 0.713 0.22±0.09 0.842 0.07±0.04 0.533 CA 34 0.08±0.05 b 0.16±0.04 0.20±0.08 0.21±0.06 0.02±0.02 0.10±0.03 0.17±0.02 0.03±0.01 CC 166 0.06±0.03 b 0.18±0.03 0.20±0.05 0.20±0.04 0.04±0.01 0.12±0.02 0.17±0.02 0.03±0.01 SNP3 CC 71 0.06±0.04 0.059 0.20±0.03 0.584 0.23±0.07 0.621 0.22±0.05 ab 0.014 0.04±0.02 0.713 0.12±0.02 0.847 0.17±0.02 0.777 0.03±0.01 0.942 GC 91 0.02±0.04 0.16±0.03 0.22±0.06 0.14±0.04 b 0.04±0.02 0.11±0.02 0.18±0.02 0.03±0.01 GG 40 0.14±0.05 0.19±0.03 0.15±0.08 0.30±0.05 a 0.03±0.02 0.13±0.02 0.16±0.02 0.03±0.01 SNP4 CC 129 0.08±0.04 0.650 0.20±0.04 0.284 0.19±0.06 0.704 0.23±0.04 0.090 0.05±0.04 0.295 0.12±0.02 0.472 0.16±0.02 0.409 0.03±0.01 0.623 CT 63 0.04±0.04 0.09±0.07 0.23±0.07 0.13±0.05 0.06±0.02 0.10±0.02 0.18±0.02 0.03±0.01 TT 10 0.03±0.09 1.02±0.20 0.14±0.14 0.22±0.10 0.03±0.04 0.09±0.04 0.21±0.04 0.02±0.02 SNP5 CC 149 0.08±0.04 0.343 0.19±0.03 0.230 0.07±0.21 0.696 0.23±0.04 0.146 0.04±0.01 0.433 0.12±0.02 0.823 0.18±0.02 0.072 0.03±0.01 0.867 CT 49 0.02±0.05 0.13±0.04 0.18±0.08 0.13±0.05 0.02±0.02 0.11±0.02 0.14±0.02 0.03±0.01 TT 4 0.04±0.14 0.18±0.11 0.22±0.06 0.14±0.15 0.02±0.05 0.09±0.07 0.12±0.06 0.02±0.03 SNP6 AA 6 0.30±0.11 0.095 0.37±0.09 0.083 0.39±0.18 0.504 0.46±0.12 0.092 0.06±0.05 0.476 0.22±0.05 0.151 0.24±0.05 0.225 0.04±0.02 0.453 GA 57 0.05±0.04 0.17±0.03 0.18±0.07 0.21±0.05 0.05±0.02 0.12±0.02 0.18±0.02 0.02±0.01 GG 139 0.06±0.04 0.18±0.03 0.21±0.06 0.19±0.04 0.03±0.02 0.11±0.02 0.16±0.02 0.03±0.01 SNP7 AA 46 0.08±0.05 0.806 0.17±0.04 0.757 0.26±0.07 0.251 0.19±0.05 0.251 0.04±0.02 0.989 0.12±0.02 0.178 0.17±0.02 0.955 0.03±0.01 0.892 GA 97 0.05±0.04 0.18±0.03 0.15±0.06 0.18±0.04 0.04±0.02 0.10±0.02 0.17±0.02 0.03±0.01 GG 59 0.07±0.05 0.20±0.04 0.24±0.07 0.26±0.05 0.04±0.02 0.14±0.02 0.17±0.02 0.03±0.01 Data in shown as “Mean ± SE”; Data in the same column with different lowercase letters on the shoulders indicate significant differences ( P <0.05). Table 8. Correlations between ACACB genotypes and contents of different fatty acids in Gannan yak. SNPs Genetypes Fatty acid (%) No. SFA P -value MUFA P -value PUFA P -value SCFA P -value MCFA P -value SNP1 AA 6 67.77±3.29 0.264 22.95±3.04 0.215 4.56±0.66 0.853 1.24±0.22 0.611 6.84±0.94 0.571 GA 30 70.20±1.64 20.69±1.51 4.17±0.33 1.41±0.11 7.87±0.47 GG 166 67.90±0.98 23.18±0.91 4.24±0.20 1.32±0.07 7.59±0.28 SNP2 AA 2 71.64±5.57 0.319 19.24±5.14 0.258 4.90±1.11 0.823 0.99±0.37 0.433 5.04±1.59 0.215 CA 34 69.71±1.57 21.15±1.45 4.19±0.31 1.41±0.10 7.84±0.45 CC 166 67.71±0.98 23.16±0.91 4.24±0.20 1.32±0.07 7.59±0.28 SNP3 CC 71 66.19±1.25 0.076 24.68±1.15 a 0.050 4.38±0.25 0.223 1.29±0.08 0.686 7.37±0.36 0.476 GC 91 68.87±1.12 22.22±1.03 ab 4.03±0.22 1.36±0.08 7.80±0.32 GG 40 68.66±1.41 21.81±1.30 b 4.46±0.28 1.33±0.10 7.56±0.41 SNP4 CC 129 68.40±0.98 a 0.000 22.29±0.89 b 0.000 4.30±0.20 0.619 1.35±0.07 0.315 7.76±0.29 0.093 CT 63 68.49±1.22 a 22.75±1.11 b 4.07±0.25 1.31±0.09 7.44±0.36 TT 10 57.27±2.48 b 34.15±2.26 a 4.27±0.52 1.10±0.17 6.25±0.74 SNP5 CC 149 67.76±1.03 0.661 23.08±0.96 0.792 4.27±0.20 0.357 1.20±0.09 0.060 7.52±0.29 0.307 CT 49 68.93±1.42 22.49±1.32 3.95±0.28 1.79±0.26 7.42±0.40 TT 4 68.27±3.93 21.22±3.63 4.77±0.78 0.14±0.15 9.25±1.12 SNP6 AA 6 68.00±3.32 0.967 21.03±3.07 0.815 5.12±0.66 0.357 1.41±0.22 0.556 7.81±0.95 0.575 GA 57 68.23±1.26 22.81±1.17 4.24±0.25 1.27±0.08 7.37±0.36 GG 139 67.91±1.07 22.96±0.98 4.19±0.21 1.36±0.07 7.74±0.30 SNP7 AA 46 66.43±1.36 0.090 24.61±1.26 0.058 4.31±0.27 0.643 1.24±0.09 0.367 7.15±0.39 0.190 GA 97 69.25±1.11 21.66±1.02 4.13±0.22 1.37±0.07 7.87±0.32 GG 59 67.32±1.28 23.34±1.18 4.35±0.26 1.35±0.09 7.58±0.37 Data in shown as “Mean ± SE”; Data in the same column with different lowercase letters on the shoulders indicate significant differences ( P <0.05). 6. The Effects of ACACB Diplotypes on Milk Quality The effects of different diplotypes of the ACACB gene in Gannan yaks on milk quality traits are shown in Table 9. It can be seen that the milk fat percentages in individuals with the H2H2 diplotype were significantly higher than in those with diplotypes H1H2, H2H3, H2H4, H2H5, H3H3, and H3H4 ( P 0.05). The results indicated that H2H2 was the dominant diplotype and could thus be used as a marker for improving milk quality traits in Gannan yaks. Table 9. Effects of ACACB diplotypes on milk quality traits in Gannan yak. Diplotypes Meat quality No. Protein rate/% Fat rate/% Lactose rate/% Total solids/% Non-fat solids/% H1H2 8 5.53±0.35 4.29±0.62 c 4.94±0.18 16.96±1.18 11.75±0.58 H2H2 22 5.31±0.23 6.09±0.41 a 4.82±0.12 17.49±0.78 11.79±0.38 H2H3 14 4.60±0.28 5.66±0.49 ab 4.78±0.15 15.90±0.94 10.76±0.46 H2H4 18 5.08±0.24 5.20±0.42 abc 4.76±0.12 15.60±0.80 11.49±0.39 H2H5 11 4.98±0.30 5.30±0.53 abc 4.69±0.16 17.00±1.00 10.97±0.49 H3H3 10 5.34±0.31 4.72±0.55 bc 5.13±0.16 16.35±1.06 11.92±0.52 H3H4 14 4.82±0.27 4.32±0.47 c 4.65±0.14 14.50±0.91 10.87±0.44 P- value 0.145 0.018 0.251 0.119 0.206 Data in shown as “Mean ± SE”. Data in the same column with different lowercase letters on the shoulders indicate significant differences ( P <0.05). 7. Effect of Presence/Absence of ACACB Haplotypes on Milk Quality The effects of the presence and absence of ACACB haplotypes on milk quality traits are shown in Table 10. It can be seen that the percentage of milk fat in individuals carrying haplotype H2 was significantly greater than that in individuals with the deletion ( P <0.05), while the total solid content in individuals carrying haplotypes H2 and H4 was significantly lower than that of individuals with the deletion ( P <0.05). The results showed that the presence of haplotype H2 resulted in higher milk fat contents, while the presence of haplotypes H2 and H4 led to lower contents; differences in the presence or absence of the other haplotypes were not significant ( P >0.05). Discussion 1. Genetic Characterization of ACACB in the Gannan Yak The present study investigated, for the first time, the relationship between genetic variation in three different regions of ACACB in the Gannan yak and milk quality traits and fatty acid contents. Correlation analysis showed that the polymorphic loci SNP1, SNP3, SNP5, SNP6, and SNP7 genotypes of ACACB were significantly correlated with the fatty acid contents, milk fat percentages, lactose contents, milk protein percentages, total solid contents, and C11:0, C18:0, and C20:3n8C contents in the milk of Gannan yaks. SNP3 and SNP4 were significantly associated with the fatty acid contents of milk fat, including SFA and MUFA. Han et al. observed the variant locus g.66218726 T>C in ACACB of Chinese Holstein cows to be significantly associated with both milk yield and fat content 20 . Genetic variation in intron 18 of ACACB has been found to be associated with obesity and kidney disease in humans 22,23 . These findings indicate that there is considerable polymorphism in the ACACB gene in both humans and livestock species, and it is hypothesized that the SNP loci identified in the present study may be functional, although further confirmation is needed. PIC and He are indicators of the degree of genetic variation within a population, with the magnitude of their values reflecting the overall level of genetic variation in the population; the larger the value, the richer the genetic diversity and the greater the potential for selection 24 . Among the seven SNP loci investigated in this study, the SNP 1, 2, 5, and 6 loci showed low polymorphism (PIC≤0.25), SNP3, while the SNP4 and SNP7 loci were moderately polymorphic (0.25<PIC<0.5), suggesting that these seven SNP loci may be suitable for analyzing linkages between traits and genetic markers. 2. ACACB Gene Polymorphisms Affect Milk Quality Traits and Fatty Acid Contents in the Gannan Yak The findings showed that genetic variation at the SNP 1, 2, 3, 5, and 7 loci in the ACACB gene was significantly correlated with milk quality traits in Gannan yaks. The ACACB gene, as a new candidate gene for genetic markers of milk improvement, encodes an enzyme involved in lipid metabolism, that is mainly expressed in tissues associated with high energy production, such as skeletal muscle, the myocardium, and liver. The enzyme is expressed on the outer mitochondrial membrane close to CTP1, where it functions as a negative regulator of fatty acid oxidation 25,26 . ACACA (acetyl coenzyme A carboxylase alpha), an isoform of ACACB, is an enzyme that regulates fatty acid synthesis and is traditionally regarded as a major regulator of the rate-limiting step in de novo lipogenesis 27 . It has been shown that ACACA var-iants significantly affect milk production traits in both dairy goats and cows 27-29 . The ACACB gene is located in a region known to significantly influence both milk yield and milk composition 30 . The ACACB gene SNP g.66218726 T>C significantly affects several milk production traits such as milk yield and fat content 20 . It was thus hy-pothesized that ACACB genetic variants may affect quality traits in yak milk. Although a literature search did not find publications on polymorphisms in ACACB in yaks, several studies have suggested that the gene is associated with traits related to fat metabolism in cattle. In human studies, ACACB genetic variants have been associated with metabolic syndrome, the onset of type II diabetes, kidney disease, and obesity in postmenopausal women 23,31,32 . In pigs, ACACB was shown to be associated with lipid metabolic processes and obesity in Meishan pigs 33 . The fatty acid contents of milk have been found to be heritable and have heritability estimates of 0.22 to 0.71 34 . In the present study, it was found that genetic variants at SNPs 1, 2, 3, and 4 in ACACB were significantly associated with the contents of fat and different types of fatty acids in the milk of Gannan yaks. It was, therefore, hypothesized that variations in ACACB may affect the compositions of milk fat and fatty acids through the regulation of fat mobilization. SNPs are defined as substitutions, insertions, or deletions of single nucleotides and are important in animal breeding 35 . Determining the correlation between the loci of candidate SNPs and the economic traits of animals is an effective method for identifying new genetic markers, facilitating the accurate and efficient analysis of genetic diversity in breeding programs 36,37 . Protein function and gene expression are associated with the location of the SNP, whether in regulatory sequences or coding regions 38 . Exons, as protein-coding regions, make up only 1-2% of the genome, and the mutation rate of exons is about one-fifth that of non-coding regions 39 . Studies have shown that a SNP in exon 2 of the growth hormone ( GH) gene (SNP: c.100A>G) can be a useful marker in the selection of dairy goat breeds for growth and milk characteristics 40 . Polymorphisms in exons 7 and 12 of the lactoferrin gene have been associated with the incidence of mastitis in Mora buffaloes 41 while polymorphisms in exon 3 of leptin ( LEP) affect milk production traits in New Zealand Holstein-Friesian × Jersey-cross dairy cows 42 and polymorphisms in exons 2 and 5 and introns 1 and 2 of prolactin ( PRL) affect milk production traits in Italian Mediterranean river buffalo 43 . In the present study, two SNPs (SNP1 and SNP4) were detected in exons 37 and 46, respectively, of the ACACB gene in Gannan yaks, and were significantly correlated with the protein, lactose, and fatty acid contents of yak milk. These results were essentially consistent with those of previous studies but since there are fewer studies on ACACB genetic mutations and milk quality traits, the effects of these mutations on milk quality traits in the yak require further verification. There is increasing evidence showing that introns are important for the normal expression of many eukaryotic genes. Introns have a wide range of functions and are involved in almost every step of the mRNA process. Although intronic variation may not directly affect the structure of a gene, it can influence transcription efficiency by affecting regulatory elements such as enhancers or other DNA structures 44 . SNPs located in introns are also highly functional compared to those located in exons. Although introns lack coding ability, they can regulate gene expression 45 and introns in several genes have been shown to have normal transcription rates 46 . While it is well known that intronic mutations do not alter the amino acid sequence, it has been found that mutations located in introns may have similar effects to those of synonymous mutations, and that the occurrence of intronic mutations affects a number of economically important traits in animals. For example, the intronic region of the GTPase-activating protein-encoding RAP1GAP gene in lake sheep, g.13561 G>A, and the intronic region of the amino acid-transporting protein-encoding rBAT gene, g.1460 T>C, were significantly correlated with traits associated with caudal fat deposition in the sheep 47 . Amills et al. showed that the T to C substitution in intron 16 of the goat diacylglycerol O-acyltransferase-encoding DGAT1 gene had a significant effect on milk traits in goats and could be used as a marker for research 48 . In addition, in the pre-sent study, it was found that introns 37, 46, and 47 of ACACB were mutated and correlated with milk quality traits such as milk fat and lactose contents, as well as the content of different types of milk fat fatty acids in Gannan yaks. This is essentially consistent with the findings of other studies and it was hypothesized that intronic variants in ACACB had a regulatory effect on milk production in yaks. Therefore, it is hypothesized that intronic variants may affect economically important traits in yaks. In conclusion, mutations in ACACB have an important effect on yak milk quality traits, milk fat percentages, and fatty acid contents, indicating that ACACB and its genetic variants may be involved in fatty acid metabolism pathways which, in turn, regulate lipid metabolism and lead to changes in milk fat traits. However, further verification is required. 3. ACACB Gene Haplotypes and Diplotypes Affect Milk Quality and Fatty Acid Contents in Gannan Yaks To assess the effects of the SNPs on milk quality traits, this study applied a model for the association analysis of haplotypes and diplotypes and milk quality traits. Hap-lotypes are inherited more efficiently than individual SNPs 49 . The effect of a gene on an organism's traits may be related to different diplotypes of SNP sites in that gene 50 . Liu et al. found that the melanocortin-4 receptor gene Hap1/4 diplotypes (ACC-ATG) were more strongly associated with carcass quality traits than other diplotypes in a Chinese indigenous beef cattle breed 51 . Gui et al. reported the individuals carrying Hap5/5 diplotypes (CC-GG-GG-GG-CC) of the hormone-sensitive lipase ( HSL ) gene in Chinese cattle breeds had greater levels of intramuscular fat content compared with other diplotypes 52 . Genetic variation in the promoter region of LAP3 dairy cows with the diplotype H1H3 (CTACGCT/GCGTACG) is associated with higher levels of lactation relative to other diplotypes 53 . Studies on genetic variation in the prolactin gene in Holstein dairy cattle showed that the H2H8 diplotype was significantly asso-ciated with milk production traits 54 . Perna et al. found that β-κ-casein (CN) haplo-types A1A, A1B, A1E, A2A, and A2B were associated with milk yield and fat content in Ayrshire dairy cows in Finland 55 . The results of the present study revealed that the highest milk fat rate was associated with the H2H2 diplotype of the ACACB gene in Gannan yaks, which was significantly higher than other diplotypes; the milk fat con-tents of the milk from individuals carrying haplotype H2 were significantly higher than that in individuals with the deletion, and the total solid contents in individuals carrying haplotypes H2 and H4 were significantly lower than those of individuals with the deletion. This may be due to the fact that the ACACB gene and its SNPs affect fat mobilization by influencing the fatty acid oxidation pathway to regulate both milk quality and milk fat fatty acid contents, although the specific regulatory mechanism requires further investigation to determine the link between genetic variation and milk quality. Materials and Methods 1. Animals and Sample Collection Blood samples (10 mL) were collected from the jugular veins of 202 female Gannan yaks with calves; all yaks had had three litters and were at the same stage of lactation. The blood was collected into anticoagulant citrate dextrose solution (Acid-Citrate-Dextrose, ACD) and was brought back to the laboratory and frozen at -70℃ before genomic DNA extraction. The animal study was approved by the Animal Care Committee at Gansu Agricultural University (approval number GAU-LC-2020-056). All animals in this study were approved by the Animal Ethics Committee of Gansu Agricultural University (approval number 2006-398). All methods were performed in accordance with the relevant guidelines and regulations. The age, group, and litter size of all yaks from which blood samples were collected were recorded, and milk samples (25 mL) were collected once in the morning and once in the evening for three consecutive days. The samples were transferred to the laboratory on ice for the evaluation of milk quality characteristics. 2. Methods 2.1. Determination of milk quality traits The milk samples were sent to the Quality Supervision, Inspection and Testing Center for Animal Hides and Skins and Products of the Ministry of Agriculture (Lanzhou, China) for trait analysis using a FOSS Milk Composition Analyzer (FOSS, Hillerød, Denmark). The traits analyzed included the levels of lactose, milk protein, and milk fat, and the contents of total solids and non-fat solids. 2.2. Extraction of genomic DNA Genomic DNA was extracted from the yak blood using a Whole-Genome Blood DNA Extraction Kit (Centrifugal Column Type), according to the manufacturer’s instructions, and the DNA integrity, purity and concentration were evaluated by 1.5% agarose gels and spectrophotometry, using a NanoDropTM Lite spectrophotometer (Thermo Fisher, Waltham, MA, USA), and stored at -20℃ until use. 2.3. Primer design and synthesis Primers were designed according to the yak ACACB sequence provided in the Ensembl database (ENSBMUG00000022222) using Primer Premier 5.0 software and the primer information is referenced in that literature 21 . The primers were synthesized by Beijing Kengke Biological Company (Xi'an, China). 2.4. Detection of SNP loci by PCR amplification and hybrid pool sequencing The total volume of the PCR reaction was 20 μL and included 0.8 μL of each of the upstream and downstream primers, 0.8 μL of genomic DNA, 10.0 μL of Taq DNA polymerase, and 7.6 µL of ddH 2 O. The PCR reaction conditions were pre-denaturation at 94 ℃ for 5 min, denaturation at 94 ℃ for 30 s, annealing at 60 ℃ for 30 s, extension at 72 ℃ for 30 s (35 cycles), and extension at 72 ℃ for 10 min. The PCR products were preserved at 4 ℃. Two microliters of the PCR amplification products from each of the 20 blood samples of the unrelated yaks were removed, and the mixed products to form a mixed pool. And then sent to Beijing Kengke Biological Company for sequencing. 2.5. Determination of genotype The genomic DNA samples were sent to King Peptide Biologicals (Wuhan, China) for typing and determination of their genotypes using the KASP method. 3. Statistics and Data Analysis Microsoft Excel 2016 was used to collate the data, and the genotype frequency and allele frequency, observed homozygosity (Ho), number of effective alleles (Ne), heterozygosity (He), and polymorphic information content (PIC) were calculated. Linkage disequilibrium and haplotypes of the SNPs were analyzed using SHEsis software (http://analysis.biox.cn/myAnalysis.php). Genotypes, haplotypes, and diplotypes of SNPs were analyzed to determine associations with milk quality traits using a general linear model (GLM) with SPSS 26.0 software. The statistical model was as follows: Y ijk = μ + Genotype i / Haplotype i + Parity j + Group k + e ijk , where Y ijk represents the phenotypic observation; µ represents the population mean; Genotype represents the fixed effect of genotype; Haplotype represents the fixed effect of haplotype; Parity j represents the fixed effect of litter size; Group k represents the fixed effect of population; e ijk represents the random error. Conclusions In this study, the influence of genetic variants in the ACACB gene on yak milk quality traits was investigated for the first time. Potential functional mutations in ACACB were identified, which can be used as molecular markers for the selection and breeding of yaks yielding high-quality milk, and provide a reference for an in-depth investigation on the influence of the yak ACACB gene on yak milk quality traits. Declarations Data Availability: Data are contained within the article. The sequences data in our study has been uploaded to the NCBI gene bank and GenBank accession number are as follows: BankIt2726640 Sequence_1 OR348640; BankIt2726640 Sequence_2 OR348641; BankIt2726640 Sequence_3 OR348642; BankIt2726640 Sequence_4 OR348643; BankIt2726640 Sequence_5 OR348644; BankIt2726640 Sequence_6 OR348645; BankIt2726640 Sequence_7 OR348646; BankIt2726640 Sequence_8 OR348647. Statement: This study was reported in accordance with ARRIVE guidelines (https://arriveguidelines.org/). Acknowledgements : We give thanks all participants for their advice and support of this study. Author Contributions: Conceptualization, X.W. methodology, Y.Q.; software, B.M.; validation, C.C.; formal analysis, S.C.; investigation, Y.Q. and C.Z.; resources, Z.Z.; data curation, F.Z.; writing—original draft preparation, C.Z.; writing—review and editing, X.L.; visualization, J.W. and Z.H.; project administration, B.S.; funding acquisition, J.H. 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Sequence and Haplotypes Variation of the Ovine Uncoupling Protein-1 Gene (UCP1) and Their Association with Growth and Carcass Traits in New Zealand Romney Lambs. Genes , doi:10.3390/genes9040189 (2018). Zhang, Y. et al. Effects of KPNA7 gene polymorphisms on reproductive traits in France Large White pigs. Journal of Applied Animal Research , doi:10.1080/09712119.2021.1965609 (2021). Mopidevi, B., Sivankutty, I., Hao, S., Ferreri, N. R. & Kumar, A. Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice. Journal of Biological Chemistry , doi:10.1074/jbc.ra120.013047 (2020). Ma, Z. et al. Ovine RAP1GAP and rBAT gene polymorphisms and their association with tail fat deposition in Hu sheep. Frontiers in Veterinary Science , doi:10.3389/fvets.2022.974513 (2022). Angiolillo, A. et al. Identification of a single nucleotide polymorphism at intron 16 of the caprine Acyl-Coenzyme A: diacylglycerol acyltransferase 1 (DGAT1) gene. Journal of Dairy Research , doi:10.1017/s0022029906002196 (2006). Fallin, D. et al. Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome Research , doi:10.1101/gr.148401 (2001). Magotra, A., Gupta, I. D., Ahmad, T. & Alex, R. Polymorphism in DNA repair gene BRCA1 associated with clinical mastitis and production traits in indigenous dairy cattle. Research in Veterinary Science , doi:10.1016/j.rvsc.2020.09.013 (2020). Liu, G. Y. et al. The genetic polymorphisms of melanocortin-4 receptor gene are associated with carcass quality traits in a Chinese indigenous beef cattle breed. Research in Veterinary Science , doi:10.1016/j.rvsc.2020.06.011 (2020). Gui, L.-S. et al. Association of Hormone-sensitive lipase (HSL) gene polymorphisms with the intramuscular fat content in two Chinese beef cattle breeds. Genomics , doi:10.1016/j.ygeno.2020.06.037 (2020). Destaw, W., Gopal, G. & Archana, V. Genetic variation in promoter region of the bovine LAP3 gene associated with estimated breeding values of milk production traits and clinical mastitis in dairy cattle. bioRxiv - Genetics , doi:10.1101/2023.04.03.535206 (2023). He, F., Sun, D., Yu, Y., Wang, Y. & Zhang, Y. Association between SNPs within Prolactin Gene and Milk Performance Traits in Holstein Dairy Cattle. Animal Bioscience , doi:10.5713/ajas.2006.1384 (2006). Perna, A., Intaglietta, I., Gambacorta, E. & Simonetti, A. The influence of casein haplotype on quality, coagulation, and yield traits of milk from Italian Holstein cows. Journal of Dairy Science , doi:10.3168/jds.2015-10463 (2016). Additional Declarations No competing interests reported. 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09:38:21","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3893649/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3893649/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":51741737,"identity":"9abd68e4-631e-464e-acdc-2adef331b656","added_by":"auto","created_at":"2024-02-28 09:07:54","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":46642,"visible":true,"origin":"","legend":"\u003cp\u003eElectrophoresis of amplified fragments of the \u003cem\u003eACACB\u003c/em\u003e gene from Gannan yak. \u003cstrong\u003eNote:\u003c/strong\u003e M, DL2000 DNA Marker; 1‒3. The primers were P1 (455 bp), P2 (362 bp), and P3 (790 bp).\u003c/p\u003e","description":"","filename":"1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-3893649/v1/5bab3618ace96d685113ab0c.jpg"},{"id":51741744,"identity":"59ec9cb6-1b92-4e87-82f3-548523dc2926","added_by":"auto","created_at":"2024-02-28 09:07:56","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":38132,"visible":true,"origin":"","legend":"\u003cp\u003eLinkage disequilibrium analysis of \u003cem\u003eACACB\u003c/em\u003e from Gannan yak.\u003c/p\u003e","description":"","filename":"2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-3893649/v1/646113f32e59a12fc27a9e1b.jpg"},{"id":76627913,"identity":"3658d2ae-c46d-465e-b3d5-e6d44eddd98d","added_by":"auto","created_at":"2025-02-19 06:03:34","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1849282,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3893649/v1/af5fc9ed-ad34-4d52-9c22-f31ae977f207.pdf"},{"id":51741742,"identity":"e727c6b8-b49e-440f-b872-6eb0ae8e421a","added_by":"auto","created_at":"2024-02-28 09:07:55","extension":"pdf","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":123278,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryInformationfileFigure1.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3893649/v1/d8d14ff95d1cb64912907997.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak","fulltext":[{"header":"Introduction","content":"\u003cp\u003eThe yak, \u003cem\u003eBos grunniens\u003c/em\u003e, is the largest ruminant unique to the Tibetan Plateau and its neighboring high-altitude regions, where it can survive in the harsh environmental conditions, including low oxygen levels\u003csup\u003e1\u003c/sup\u003e. The yak provides products such as meat, milk, wool, and fleece, as well as animal power, fuel, and transportation, for local herders\u003csup\u003e2\u003c/sup\u003e and is thus an indispensable livestock species in the local economy. Yak milk is thick, sweet, and rich in nutrients, and is known as \u0026quot;natural concentrated milk\u0026quot;. The milk also contains higher levels of dry matter, protein, fatty acids, minerals, and other nutrients than cow\u0026rsquo;s milk, and yak milk is also rich in vitamins A and C, has significant antioxidant properties, and is one of the best raw milks for the processing of cream products\u003csup\u003e3\u003c/sup\u003e. Yak milk is rich in protein, with a protein fraction of 5.32%\u003csup\u003e4\u003c/sup\u003e and enhances the gastrointestinal immune function, absorption of calcium and phosphorus absorption, and has significant potential for the development of infant milk products\u003csup\u003e5\u003c/sup\u003e. It is known that milk production in mammals such as cows is affected by factors such as the genetics, breed, and nutritional level of the animal, as well as the calving litter size, calving age, and lactation season. Genetic studies of milk production have mainly focused on improving the yield and protein and fat contents of the mill. Milk fat is mainly composed of triglycerides and small amounts of cholesterol, diglycerides, monoglycerides, and free fatty acids, mostly short-chain saturated fatty acids (SFAs) together with phospholipids, sterols, pigments, and fat-soluble vitamins, all of which are easy for the body to digest and absorb. Furthermore, milk fat has an aromatic odor and is an important source of flavor in dairy products. Therefore, the percentage of milk represents a key indicator of the nutritional value of the milk, and reflects the production performance of dairy cows with economic consequences. In this study, we analyzed candidate genes associated with milk fat traits in the yak and investigated the effects of genetic mutation on milk quality.\u003c/p\u003e\n\u003cp\u003eGenes associated with milk fats are mostly associated with fatty acid and triglyceride synthesis. Lactation is regulated by multiple genes. For example, polymorphisms in exon 1 G\u0026gt;C and exon 34 A\u0026gt;G of the fatty acid synthase FASN gene are associated with milk fat content in Chinese Holstein cows\u003csup\u003e6\u003c/sup\u003e. While polymorphisms in signal transducer and activator of transcription 5A (\u003cem\u003eSTAT5A\u003c/em\u003e) influence both milk yield and fat percentage\u003csup\u003e7\u003c/sup\u003e and polymorphisms in fatty acid-binding protein 3 (\u003cem\u003eFABP3\u003c/em\u003e) were found to be significantly correlated with milk fat traits in Mehsana buffaloes\u003csup\u003e8\u003c/sup\u003e. Acetyl-coenzyme A carboxylase (ACC) was discovered in the late 1950s by Salih et al. It is a biotin-dependent carboxylase, belonging to the intermolecular carboxylation transfer family, which catalyzes the carboxylation of acetyl-coenzyme A to malonyl-monoacyl-coenzyme A during fatty acid synthesis and metabolism. ACC consists of two isomers, \u0026alpha; and \u0026beta;, and plays a major regulatory role in the regulation of fatty acid metabolism\u003csup\u003e9,10\u003c/sup\u003e. Acetyl-CoA carboxylase beta is encoded by the acetyl-CoA carboxylase beta gene (\u003cem\u003eACACB\u003c/em\u003e). The protein is localized outside the mitochondria and regulates the activity of carnitine palmitoyltransferase1 (CPT-1), preventing the transport of fatty acids into the mitochondria for fatty acid beta-oxidation\u003csup\u003e11\u003c/sup\u003e. It is a rate-limiting enzyme that promotes lipid synthesis and plays a key regulatory role in lipid metabolism. Studies have shown that the \u003cem\u003eACACB\u003c/em\u003e gene is located in a quantitative trait locus (QTL) region known to significantly influence fat yield\u003csup\u003e12,13\u003c/sup\u003e. Much of the current research on \u003cem\u003eACACB\u003c/em\u003e has focused on diseases such as cancer and obesity in humans and mice. The \u003cem\u003eACACB\u003c/em\u003e protein is abundantly expressed in skeletal and cardiac muscle\u003csup\u003e14-17\u003c/sup\u003e, as well as in the liver, and is also found in mammalian brown adipose tissue, mammary glands, and pancreatic islets\u003csup\u003e11,17\u003c/sup\u003e. Common polymorphisms in \u003cem\u003eACACB\u003c/em\u003e are associated with diseases such as obesity. Harwood et al. found that persistent fatty acid oxidation in adipocytes in \u003cem\u003eACACB\u003c/em\u003e -knockout mice protects against obesity and diabetes and is accompanied by reductions in abdominal fat stores\u003csup\u003e18,19\u003c/sup\u003e. Han et al. showed that single nucleotide polymorphisms (SNPs) in \u003cem\u003eACACB\u003c/em\u003e in Chinese Holstein cows were significantly correlated with the overall yield, fat yield, fat percentage, protein yield, and protein percentage in the milk\u003csup\u003e20\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eCurrently, genetic breeding is an important initiative to improve milk production in yaks. However, most studies on \u003cem\u003eACACB\u003c/em\u003e have focused on its role in cancer and obesity-related diseases, with only a few studies focusing on animal production traits. In the present study, polymorphisms in the key \u003cem\u003eACACB\u003c/em\u003e gene were investigated in a population of Gannan yaks, with the aim of assessing the effects of \u003cem\u003eACACB\u003c/em\u003e genetic variation and its haplotypes on milk quality traits, and provide a theoretical basis for genetic breeding to enhance the butterfat content of the milk to improve the quality of milk-based products.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e1. ACACB PCR Products\u003c/p\u003e\n\u003cp\u003eAs shown by analysis of 1.5% agarose gels (Figure 1) it can be seen that the amplification products in the lanes are clear and bright with good specificity. Three bands at 455 bp, 362 bp, and 790 bp were observed.\u003c/p\u003e\n\u003cp\u003e2. Genetic Characterization of SNPs in ACACB\u003c/p\u003e\n\u003cp\u003eThe results of our previous study showed that seven SNPs were detected in three regions of \u003cem\u003eACACB\u003c/em\u003e and each SNP had three genotypes\u003csup\u003e21\u003c/sup\u003e.\u003c/p\u003e\n\u003cp\u003eThe results of the genotype frequency, allele frequency, and population genetic polymorphism analyses of the SNPs are shown in Table 1. The dominant genotypes of the SNP1, SNP2, SNP3, SNP4, SNP5, SNP6, and SNP7 loci were GG, CC, GC, CC, CC, GG, and GA, respectively; the PIC contents were all of moderate polymorphic information status (0.25\u0026lt;PIC\u0026lt;0.5), and the SNP1, SNP2, SNP5, and SNP6 loci showed low polymorphism (PIC\u0026le;0.25), indicating that the three SNP loci, SNP3, SNP4, and SNP7, had high genetic variance and strong selection potentials. The heterozygosity results showed the highest frequency at the SNP7 locus, and the number of effective alleles showed that the two alleles at the SNP7 locus were evenly distributed in the population compared with those at the other loci.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1.\u003c/strong\u003e Analysis of genetic polymorphism in yak \u003cem\u003eACACB\u003c/em\u003e.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"709\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"6.619718309859155%\"\u003e\n \u003cp\u003eSNPs\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"31.971830985915492%\" colspan=\"3\"\u003e\n \u003cp\u003eGenotype Frequency/%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.647887323943662%\" colspan=\"2\"\u003e\n \u003cp\u003eAllele Frequency/%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.380281690140846%\"\u003e\n \u003cp\u003ePIC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.704225352112676%\"\u003e\n \u003cp\u003eHe\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.028169014084508%\"\u003e\n \u003cp\u003eHo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.647887323943662%\"\u003e\n \u003cp\u003eNe\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eSNP1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eAA（6）\u003c/p\u003e\n \u003cp\u003e2.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eGA（30）\u003c/p\u003e\n \u003cp\u003e14.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eGG（166）\u003c/p\u003e\n \u003cp\u003e82.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003cp\u003e10.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003cp\u003e89.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.361462728551336%\"\u003e\n \u003cp\u003e0.1690\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003e0.1863\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003e0.8137\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.627285513361462%\"\u003e\n \u003cp\u003e1.2290\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eSNP2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eAA（2）\u003c/p\u003e\n \u003cp\u003e0.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eCA（34）16.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eCC（166）\u003c/p\u003e\n \u003cp\u003e82.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003cp\u003e9.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003cp\u003e90.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.361462728551336%\"\u003e\n \u003cp\u003e0.1559\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003e0.1704\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003e0.8296\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.627285513361462%\"\u003e\n \u003cp\u003e1.2054\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eSNP3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eCC（71）\u003c/p\u003e\n \u003cp\u003e35.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eGC（91）\u003c/p\u003e\n \u003cp\u003e45.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eGG（40）\u003c/p\u003e\n \u003cp\u003e19.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003cp\u003e57.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003cp\u003e42.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.361462728551336%\"\u003e\n \u003cp\u003e0.3690\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003e0.4882\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003e0.5118\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.627285513361462%\"\u003e\n \u003cp\u003e1.9540\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eSNP4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eCC（129）\u003c/p\u003e\n \u003cp\u003e63.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eCT（63）\u003c/p\u003e\n \u003cp\u003e31.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eTT（10）\u003c/p\u003e\n \u003cp\u003e4.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003cp\u003e79.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003eT\u003c/p\u003e\n \u003cp\u003e20.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.361462728551336%\"\u003e\n \u003cp\u003e0.2732\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003e0.3265\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003e0.6735\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.627285513361462%\"\u003e\n \u003cp\u003e1.4847\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eSNP5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eCC（149）\u003c/p\u003e\n \u003cp\u003e73.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eCT（49）\u003c/p\u003e\n \u003cp\u003e24.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eTT（4）\u003c/p\u003e\n \u003cp\u003e1.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003cp\u003e85.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003eT\u003c/p\u003e\n \u003cp\u003e24.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.361462728551336%\"\u003e\n \u003cp\u003e0.2130\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003e0.2424\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003e0.7576\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.627285513361462%\"\u003e\n \u003cp\u003e1.3199\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eSNP6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eAA（6）\u003c/p\u003e\n \u003cp\u003e2.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eGA（57）\u003c/p\u003e\n \u003cp\u003e28.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eGG（139）\u003c/p\u003e\n \u003cp\u003e68.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003cp\u003e17.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003cp\u003e82.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.361462728551336%\"\u003e\n \u003cp\u003e0.2431\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003e0.2832\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003e0.7168\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.627285513361462%\"\u003e\n \u003cp\u003e1.3952\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eSNP7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eAA（46）\u003c/p\u003e\n \u003cp\u003e22.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eGA（97）\u003c/p\u003e\n \u003cp\u003e48.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003eGG（59）\u003c/p\u003e\n \u003cp\u003e29.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.610407876230661%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003cp\u003e46.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003cp\u003e53.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.361462728551336%\"\u003e\n \u003cp\u003e0.3740\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.68917018284107%\"\u003e\n \u003cp\u003e0.4979\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.016877637130802%\"\u003e\n \u003cp\u003e0.5021\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.627285513361462%\"\u003e\n \u003cp\u003e1.9918\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e3. Linkage Disequilibrium and Haplotype Analysis of SNPs\u003c/p\u003e\n\u003cp\u003eThe results of the linkage disequilibrium analysis of the loci of the seven SNPs in \u003cem\u003eACACB\u003c/em\u003e are shown in Figure 2. Strong linkage disequilibrium was seen between SNP1 and SNP2 (r\u003csup\u003e2\u003c/sup\u003e=0.89), while no strong linkage was observed between the other SNPs (r\u003csup\u003e2\u003c/sup\u003e\u0026lt;0.33). The results of haplotype analysis are shown in Table 2; excluding haplotypes with frequencies lower than 3% in the Gannan yak population, a total of seven haplotypes with frequencies greater than 3% were detected, of which, haplotype H2 had the highest frequency of 29.20%, followed by 19.50% for H3, and 14.60% for H4, while H1, H5, H6, and H7 had lower frequencies of 7.10%, 9.40%, 3.40% and 3.90% respectively. A total of 28 diplotypes were found for the seven haplotypes. After exclusion of diplotypes with frequencies lower than 5%, seven were identified, namely, H1H2, H2H2, H2H3, H2H4, H2H5, H3H3, and H3H4, with the frequencies of 5.23, 14.38, 9.15, 11.76, 7.19, 6.54, and 9.15%, respectively.\u003c/p\u003e\n\u003cp\u003eThe values of \u003cem\u003er\u003c/em\u003e\u003csup\u003e2\u0026nbsp;\u003c/sup\u003erepresent coefficient of LD between two sites, \u003cem\u003er\u003c/em\u003e\u003csup\u003e2\u003c/sup\u003e \u0026gt; 0.33 indicates a strong LD between sites.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2.\u003c/strong\u003e Haplotype analysis of \u003cem\u003eACACB\u003c/em\u003e mutation sites in yak.\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"699\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.142857142857142%\" rowspan=\"2\"\u003e\n \u003cp\u003eHaplotype\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"48.57142857142857%\" colspan=\"7\"\u003e\n \u003cp\u003eMutation site\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.571428571428571%\" rowspan=\"2\"\u003e\n \u003cp\u003eFrequency/%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.142857142857142%\" rowspan=\"2\"\u003e\n \u003cp\u003ediplotypes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.571428571428571%\" rowspan=\"2\"\u003e\n \u003cp\u003eFrequency/%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"13.864306784660767%\"\u003e\n \u003cp\u003eSNP1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.864306784660767%\"\u003e\n \u003cp\u003eSNP2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.864306784660767%\"\u003e\n \u003cp\u003eSNP3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.864306784660767%\"\u003e\n \u003cp\u003eSNP4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.864306784660767%\"\u003e\n \u003cp\u003eSNP5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.864306784660767%\"\u003e\n \u003cp\u003eSNP6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"16.8141592920354%\"\u003e\n \u003cp\u003eSNP7\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.15450643776824%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e7.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH1H2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e5.23\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.15450643776824%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e29.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH2H2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e14.38\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.15450643776824%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e19.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH2H3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e9.15\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.15450643776824%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e14.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH2H4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e11.76\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.15450643776824%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e9.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH2H5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e7.19\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.15450643776824%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e3.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH3H3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e6.54\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eC\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.723891273247497%\"\u003e\n \u003cp\u003eG\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.15450643776824%\"\u003e\n \u003cp\u003eA\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e3.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.160228898426324%\" valign=\"top\"\u003e\n \u003cp\u003eH3H4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.590844062947067%\" valign=\"top\"\u003e\n \u003cp\u003e9.15\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e4. Analysis of the Correlation between ACACB Genotype and Milk Quality traits in Gannan Yak\u003c/p\u003e\n\u003cp\u003eThe association analysis of \u003cem\u003eACACB\u003c/em\u003e genotypes with milk quality traits in Gannan yaks is shown in Table 3. The results indicate that the lactose contents of milk from individual yaks of the AA genotype at the SNP1 locus were significantly higher than those present in the GG genotype (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05). The milk protein contents in yaks with the GC genotype at the SNP3 locus were significantly higher than those with the GG genotype (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05), while the levels of milk fat associated with the CC genotype at the SNP5 locus were markedly greater than those of the TT genotype (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05). The total solid contents in the milk from individual yaks of the GG genotype at the SNP6 locus were significantly greater than those of the GA genotype (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05), while the milk fat levels in yaks of the GG genotype at the SNP7 locus were markedly increased in comparison with yaks of the GA genotype and lactose levels in yaks with the AA genotype were significantly higher than those with the and the GG genotype (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05). There was no significant correlation between the genotypes of the SNP2 and SNP4 loci and milk quality traits (\u003cem\u003eP\u003c/em\u003e\u0026gt;0.05).\u003c/p\u003e\n\u003cp\u003eThe results indicated that the genotypes at the SNP loci in the \u003cem\u003eACACB\u003c/em\u003e gene were significantly associated with milk quality traits, suggesting their potential use as genetic markers for milk quality improvement in Gannan yaks.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3.\u0026nbsp;\u003c/strong\u003eCorrelations between \u003cem\u003eACACB\u003c/em\u003e genotypes and milk quality traits in Gannan yak.\u003c/p\u003e\n\u003ctable style=\"width: 108%;border-collapse:collapse;border:none;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:5.6%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003eSNPs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:7.02%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eGenetypes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"11\" style=\"width: 87.38%;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eMilk quality\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eNo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.26%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eProtein rate/%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e-value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eFat rate/%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.56%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e-value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eLactose rate/%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.22%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;'\u003e-value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.64%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eTotal solids/%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:red;'\u003e4.93\u0026plusmn;0.08\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:5.22%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:red;'\u003e0.040\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e16.08\u0026plusmn;0.49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.792\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.94%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e11.43\u0026plusmn;0.23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:5.78%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e0.433\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.02%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eGA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e97\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.26%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e4.95\u0026plusmn;0.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:red;'\u003e4.81\u0026plusmn;0.22\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:red;'\u003e4.82\u0026plusmn;0.07\u003csup\u003eab\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e15.94\u0026plusmn;0.40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.94%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e11.18\u0026plusmn;0.19\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.02%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003eGG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e59\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.26%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e5.14\u0026plusmn;0.13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:red;'\u003e5.39\u0026plusmn;0.26\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.28%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:red;'\u003e4.70\u0026plusmn;0.08\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.64%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e16.26\u0026plusmn;0.46\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:12.94%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;'\u003e11.41\u0026plusmn;0.21\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style='font-size:14px;font-family:\"Calibri\",sans-serif;'\u003eData are shown as Mean \u0026plusmn; SE; different lowercase letters in the same column indicate significant differences (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e5. Effects of ACACB Genotype on Different Fatty acid Contents\u003c/p\u003e\n\u003cp\u003eThe effects of \u003cem\u003eACACB\u003c/em\u003e genotypes of Gannan yak on the contents of different kinds of fatty acids are shown in Tables 4-8. The results showed that different genotypes at different SNP loci affected the levels of various types of fatty acids. Specifically, the C20:3n8C contents in individual yaks of the AA genotype at the SNP1 locus were significantly higher than that of the GG and GA genotypes (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05), and the C11:0, C18:0, and C20:3n8C contents in yaks with the AA genotype at the SNP2 locus was significantly greater than those of the CC and CA genotypes (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05 and \u003cem\u003eP\u003c/em\u003e\u0026lt;0.01, respectively). C11:0, C18:0, and C20:3n8C were also markedly increased compared with the CC and CA genotypes (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05 and \u003cem\u003eP\u003c/em\u003e\u0026lt;0.01, respectively) while C14:0 and C16:0 were significantly higher in yaks with the GC genotype compared with the CC genotype at the SNP3 locus (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05), and C23:0 was significantly higher than in the GG genotype in yak individuals of both GC and CC genotypes (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05). In terms of monounsaturated fatty acids (MUFAs), the MUFA levels were significantly higher in the CC genotype compared with the GC and GG genotypes (\u003cem\u003eP\u003c/em\u003e=0.05) while the C10:0, C14:0, C16:0, and SFA contents in SNP4 locus/CC and CT genotype yak individuals were significantly greater than those of the TT genotype (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.01) and the TT genotype was associated with markedly higher (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05, \u003cem\u003eP\u003c/em\u003e\u0026lt;0.01) levels of C17:1C, C18:1C, C18:3n6, and MUFA than the CC and CT genotypes. The SNP5 locus/CT genotype yak individuals had significantly (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05) higher levels of C16:0 and C18:0 than those with the CC and TT genotypes, while genotypes associated with the SNP6 and SNP7 loci showed no significant associations with the levels of different types of fatty acids (\u003cem\u003eP\u003c/em\u003e\u0026gt;0.05).\u003c/p\u003e\n\u003cp\u003eThe results indicated that the genotypes at the SNP loci of the Gannan yak \u003cem\u003eACACB\u003c/em\u003e gene that were significantly or highly significantly associated with the contents of different types of fatty acids could be used as markers for the improvement of the fatty acid contents of Gannan yak milk.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 4.\u0026nbsp;\u003c/strong\u003eCorrelations between \u003cem\u003eACACB\u003c/em\u003e genotypes and contents of different fatty acids in Gannan yak.\u003c/p\u003e\n\u003ctable style=\"width: 105%;border-collapse:collapse;border:none;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:3.78%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eSNPs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:5.62%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eGenetypes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"19\" style=\"width:90.6%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eFatty acid (%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:2.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eNo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC4:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.7%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC6:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.74%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.62%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eC8:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.7%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.92%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family: \"Times New Roman\",serif;color:black;'\u003eC10:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e7.31\u0026plusmn;0.76\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.8%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.709\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.76%;border: none;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.63\u0026plusmn;0.13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.76%;border: none;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.24\u0026plusmn;0.03\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.72%;border: none;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.36\u0026plusmn;0.08\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.32\u0026plusmn;0.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.62%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.35\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.92%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.37\u0026plusmn;0.11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e7.29\u0026plusmn;0.89\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.76%;border: none;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.27\u0026plusmn;0.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp 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0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e59\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.35\u0026plusmn;0.09\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.25\u0026plusmn;0.13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.62%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.24\u0026plusmn;0.08\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.92%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e2.26\u0026plusmn;0.13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.24\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:14.15pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e1.59\u0026plusmn;0.10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.76%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.24\u0026plusmn;0.03\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.72%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e7.90\u0026plusmn;0.29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.76%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 14.15pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:12.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Times New Roman\",serif;color:black;'\u003e0.53\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:justify;text-indent:.25in;line-height:95%;font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e\u003cspan style=\"font-size:12px;line-height:95%;\"\u003eData in shown as \u0026ldquo;Mean \u0026plusmn; SE\u0026rdquo;; Data in the same column with different lowercase letters on the shoulders indicate significant differences (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 5.\u0026nbsp;\u003c/strong\u003eCorrelations between \u003cem\u003eACACB\u003c/em\u003e genotypes and contents of different fatty acids in Gannan yak.\u003c/p\u003e\n\u003ctable style=\"width: 106%;border-collapse:collapse;border:none;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:3.78%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNPs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:6.64%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGenetypes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"19\" style=\"width:89.56%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eFatty acid (%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:2.82%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eNo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC15:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.26%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC15:1C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.7%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC16:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.7%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC16:1C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.72%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC17:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.72%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC17:1C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.7%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.5%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC18:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.7%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC18:1T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.72%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC18:1C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.68%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e24.82\u0026plusmn;2.55\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.308\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.75\u0026plusmn;0.59\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.584\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e17.50\u0026plusmn;3.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.68%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.321\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 2.82%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e23.72\u0026plusmn;1.27\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.11\u0026plusmn;0.29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.11\u0026plusmn;0.44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.26%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.080\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.37\u0026plusmn;0.22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.779\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e23.26\u0026plusmn;4.92\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.277\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.30\u0026plusmn;0.40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.130\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.92\u0026plusmn;0.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.356\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.18\u0026plusmn;0.86\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.800\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.5%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e38.40\u0026plusmn;4.17\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.864\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e15.39\u0026plusmn;5.28\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.68%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e17.98\u0026plusmn;0.93\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e22.28\u0026plusmn;0.87\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.15\u0026plusmn;0.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e17.03\u0026plusmn;1.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 2.82%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.13\u0026plusmn;0.11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.21\u0026plusmn;0.06\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e31.54\u0026plusmn;1.24\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.84\u0026plusmn;0.10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.91\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.36\u0026plusmn;0.22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.5%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e21.92\u0026plusmn;1.10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.20\u0026plusmn;0.26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e17.22\u0026plusmn;1.34\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eCC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 2.82%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e129\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.12\u0026plusmn;0.08\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.26%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e63\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.02\u0026plusmn;0.10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.95\u0026plusmn;0.09\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.85\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e0.63\u0026plusmn;0.19\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.5%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e22.95\u0026plusmn;0.99\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.99\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.445\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.87\u0026plusmn;0.06\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.242\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.61\u0026plusmn;0.16\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.244\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.5%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e23.13\u0026plusmn;0.79\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e0.046\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.08\u0026plusmn;0.18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.175\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e17.89\u0026plusmn;0.98\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.68%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.794\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eCT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 2.82%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.11\u0026plusmn;0.11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.20\u0026plusmn;0.06\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.88\u0026plusmn;0.26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.26%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.625\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.21\u0026plusmn;0.13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.870\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e29.00\u0026plusmn;2.93\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.594\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.64\u0026plusmn;0.24\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.221\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.83\u0026plusmn;0.18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.218\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e16.63\u0026plusmn;3.15\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.68%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e22.70\u0026plusmn;0.82\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.34\u0026plusmn;0.19\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e17.65\u0026plusmn;1.01\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.78%;border:none;border-bottom: solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.97\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.109\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.62\u0026plusmn;0.21\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.831\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.5%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e22.28\u0026plusmn;1.06\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.7%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.533\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.37\u0026plusmn;0.25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.72%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.606\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e19.21\u0026plusmn;1.29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.68%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.086\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 2.82%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e97\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.10\u0026plusmn;0.09\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.23\u0026plusmn;0.05\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e30.57\u0026plusmn;0.99\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.93\u0026plusmn;0.08\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.88\u0026plusmn;0.06\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.54\u0026plusmn;0.17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.5%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e22.99\u0026plusmn;0.87\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.16\u0026plusmn;0.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e16.52\u0026plusmn;1.05\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.64%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 2.82%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e59\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.7%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.09\u0026plusmn;0.10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.6%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.18\u0026plusmn;0.05\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e30.13\u0026plusmn;1.15\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.05\u0026plusmn;0.09\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.80\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.54%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:8.5pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.48\u0026plusmn;0.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.5%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e21.91\u0026plusmn;1.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.54%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.12\u0026plusmn;0.23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 8.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e18.37\u0026plusmn;1.22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:21.0pt;line-height:95%;font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eData in shown as \u0026ldquo;Mean \u0026plusmn; SE\u0026rdquo;; Data in the same column with different lowercase letters on the shoulders indicate significant differences (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 6.\u0026nbsp;\u003c/strong\u003eCorrelations between \u003cem\u003eACACB\u003c/em\u003e genotypes and contents of different fatty acids in Gannan yak.\u003c/p\u003e\n\u003ctable style=\"width: 102%;border-collapse:collapse;border:none;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:3.94%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNPs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:6.64%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGenetypes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"19\" style=\"width:89.42%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eFatty acid (%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:2.88%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eNo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC18:2T\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC18:2C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC20:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.86%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.1%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC18:3n6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.52%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC20:1C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC18:3n9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC21:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC20:2C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC22:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.94%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eAA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:2.88%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.64\u0026plusmn;0.18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.815\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.17\u0026plusmn;0.26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.844\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.56\u0026plusmn;0.10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.86%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.565\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.1%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.41\u0026plusmn;0.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.52%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.380\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.83\u0026plusmn;0.31\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.832\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.97\u0026plusmn;0.13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.068\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.02\u0026plusmn;0.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.327\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.15\u0026plusmn;0.13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.287\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.31\u0026plusmn;0.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.356\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.76%;border: none;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.24\u0026plusmn;0.06\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.137\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.64%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.19\u0026plusmn;0.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.76%;border: none;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.16\u0026plusmn;0.17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.94%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.29\u0026plusmn;0.09\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.52%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.449\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.81\u0026plusmn;0.15\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.633\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.92\u0026plusmn;0.13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:3.84%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.607\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.57\u0026plusmn;0.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.1%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.18\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.89\u0026plusmn;0.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.78%;border: none;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.01\u0026plusmn;0.11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.78%;border: none;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.19\u0026plusmn;0.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.78%;border: none;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.29\u0026plusmn;0.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.76%;border: none;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.17\u0026plusmn;0.05\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.64%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 2.88%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e59\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.78%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.52\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.29\u0026plusmn;0.10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.55\u0026plusmn;0.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.1%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.21\u0026plusmn;0.08\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.76%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.77\u0026plusmn;0.14\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:5.78%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.06\u0026plusmn;0.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.78%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.25\u0026plusmn;0.14\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.78%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.27\u0026plusmn;0.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 5.76%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.20\u0026plusmn;0.06\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:21.0pt;line-height:95%;font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eData in shown as \u0026ldquo;Mean \u0026plusmn; SE\u0026rdquo;; Data in the same column with different lowercase letters on the shoulders indicate significant differences (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 7.\u0026nbsp;\u003c/strong\u003eCorrelations between \u003cem\u003eACACB\u003c/em\u003e genotypes and and contents of different fatty acids in Gannan yak.\u003c/p\u003e\n\u003ctable style=\"width: 94%;border-collapse:collapse;border:none;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:5.34%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNPs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:7.18%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGenetypes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"17\" style=\"width:87.46%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eFatty acid (%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:3.14%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eNo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.8%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC20:3n8C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.62%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC22:1C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC20:4C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.28%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC23:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.16%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC22:2C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC24:0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.18%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eC20:5C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.16%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 3.14%;border: none;padding: 0in 1.4pt;height: 11.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e97\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.8%;border: none;padding: 0in 1.4pt;height: 11.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.05\u0026plusmn;0.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.18\u0026plusmn;0.03\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp 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1.5pt solid windowtext;padding: 0in 1.4pt;height: 11.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.07\u0026plusmn;0.05\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.20\u0026plusmn;0.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.24\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.28%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.26\u0026plusmn;0.05\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.04\u0026plusmn;0.02\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.24%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:11.35pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.14\u0026plusmn;0.02\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.24%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 11.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.17\u0026plusmn;0.02\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.24%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 11.35pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:12px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.03\u0026plusmn;0.01\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:21.0pt;line-height:95%;font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eData in shown as \u0026ldquo;Mean \u0026plusmn; SE\u0026rdquo;; Data in the same column with different lowercase letters on the shoulders indicate significant differences (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 8.\u0026nbsp;\u003c/strong\u003eCorrelations between \u003cem\u003eACACB\u003c/em\u003e genotypes and contents of different fatty acids in Gannan yak.\u003c/p\u003e\n\u003ctable style=\"width: 91%;border-collapse:collapse;border:none;\"\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:7.36%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNPs\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width:7.38%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGenetypes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"11\" style=\"width:85.26%;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eFatty acid (%)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:4.22%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eNo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.52%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSFA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.78%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e-value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eMUFA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.32%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e-value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003ePUFA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:6.32%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e-value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSCFA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.36%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e-value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eMCFA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.4%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e-value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:7.36%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eAA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.22%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.52%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e67.77\u0026plusmn;3.29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.264\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e22.95\u0026plusmn;3.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.32%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.215\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.56\u0026plusmn;0.66\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.32%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.853\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.24\u0026plusmn;0.22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:7.36%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.611\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e6.84\u0026plusmn;0.94\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:8.4%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.59\u0026plusmn;0.28\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:7.36%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e71.64\u0026plusmn;5.57\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.319\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e19.24\u0026plusmn;5.14\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.32%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.258\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.99\u0026plusmn;0.37\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:7.36%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.433\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e5.04\u0026plusmn;1.59\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:8.4%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.215\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e0.050\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.38\u0026plusmn;0.25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.32%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.686\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.37\u0026plusmn;0.36\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:8.4%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.476\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.22%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.30\u0026plusmn;0.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.32%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.619\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.35\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:7.36%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.315\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.76\u0026plusmn;0.29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:8.4%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.093\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eCT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.22%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e63\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.52%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e68.49\u0026plusmn;1.22\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e22.75\u0026plusmn;1.11\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.07\u0026plusmn;0.25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.31\u0026plusmn;0.09\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.44\u0026plusmn;0.36\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eTT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.22%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.52%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e57.27\u0026plusmn;2.48\u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e34.15\u0026plusmn;2.26\u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.27\u0026plusmn;0.52\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.10\u0026plusmn;0.17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e6.25\u0026plusmn;0.74\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:7.36%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eCC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.22%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.060\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.52\u0026plusmn;0.29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:8.4%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e22.49\u0026plusmn;1.32\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e3.95\u0026plusmn;0.28\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.79\u0026plusmn;0.26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.42\u0026plusmn;0.40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eTT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.22%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.52%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e68.27\u0026plusmn;3.93\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e21.22\u0026plusmn;3.63\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.77\u0026plusmn;0.78\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.14\u0026plusmn;0.15\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e9.25\u0026plusmn;1.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:7.36%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e68.00\u0026plusmn;3.32\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.78%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.967\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e22.96\u0026plusmn;0.98\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.19\u0026plusmn;0.21\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.36\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.74\u0026plusmn;0.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width:7.36%;border:none;border-bottom: solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eSNP7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eAA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:4.22%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e46\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.52%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e66.43\u0026plusmn;1.36\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.78%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.090\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e24.61\u0026plusmn;1.26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.32%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.058\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.31\u0026plusmn;0.27\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:6.32%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.643\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.24\u0026plusmn;0.09\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:7.36%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.367\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.15\u0026plusmn;0.39\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"3\" style=\"width:8.4%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.190\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 4.22%;border: none;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e97\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.52%;border: none;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e69.25\u0026plusmn;1.11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e21.66\u0026plusmn;1.02\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.13\u0026plusmn;0.22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.37\u0026plusmn;0.07\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.87\u0026plusmn;0.32\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:7.38%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eGG\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 4.22%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e59\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 10.52%;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0in 1.4pt;height: 5.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e67.32\u0026plusmn;1.28\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.04%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e23.34\u0026plusmn;1.18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:8.44%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.35\u0026plusmn;0.26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:9.48%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e1.35\u0026plusmn;0.09\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:7.38%;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 1.4pt 0in 1.4pt;height:5.65pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e7.58\u0026plusmn;0.37\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style='font-size:14px;font-family:\"Calibri\",sans-serif;'\u003eData in shown as \u0026ldquo;Mean \u0026plusmn; SE\u0026rdquo;; Data in the same column with different lowercase letters on the shoulders indicate significant differences (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e6. The Effects of ACACB Diplotypes on Milk Quality\u003c/p\u003e\n\u003cp\u003eThe effects of different diplotypes of the \u003cem\u003eACACB\u003c/em\u003e gene in Gannan yaks on milk quality traits are shown in Table 9. It can be seen that the milk fat percentages in individuals with the H2H2 diplotype were significantly higher than in those with diplotypes H1H2, H2H3, H2H4, H2H5, H3H3, and H3H4 (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05); although the other diplotypes showed associations with milk quality traits, the differences were not significant (\u003cem\u003eP\u003c/em\u003e\u0026gt;0.05).\u003c/p\u003e\n\u003cp\u003eThe results indicated that H2H2 was the dominant diplotype and could thus be used as a marker for improving milk quality traits in Gannan yaks.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 9.\u003c/strong\u003e Effects of \u003cem\u003eACACB\u003c/em\u003e diplotypes on milk quality traits in Gannan yak.\u003c/p\u003e\n\u003ctable\u003e\n \u003cthead\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width:14.42%;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eDiplotypes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width: 85.58%;border-top: 1pt solid windowtext;border-left: none;border-bottom: 1pt solid windowtext;border-right: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eMeat quality\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:6.48%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eNo.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.92%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eProtein rate/%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.62%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eFat rate/%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.26%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eLactose rate/%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.92%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eTotal solids/%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.38%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eNon-fat solids/%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/thead\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:14.42%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eH1H2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.92%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e5.53\u0026plusmn;0.35\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.62%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.29\u0026plusmn;0.62\u003csup\u003ec\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.26%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.94\u0026plusmn;0.18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.92%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e16.96\u0026plusmn;1.18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.38%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e11.75\u0026plusmn;0.58\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:14.42%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eH2H2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.92%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e5.31\u0026plusmn;0.23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.62%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e6.09\u0026plusmn;0.41\u003c/span\u003e\u003csup\u003e\u003cspan style='font-size:11px;font-family:\"Palatino Linotype\",serif;color:black;'\u003ea\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.26%;border: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.82\u0026plusmn;0.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.92%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e17.49\u0026plusmn;0.78\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.38%;border: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e11.79\u0026plusmn;0.38\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:14.42%;border:none;padding:0in 1.4pt 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eH2H5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.92%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.69\u0026plusmn;0.16\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.92%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e17.00\u0026plusmn;1.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.38%;border: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e10.97\u0026plusmn;0.49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:14.42%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eH3H3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 6.48%;border: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp 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style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.82\u0026plusmn;0.27\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.62%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.32\u0026plusmn;0.47\u003csup\u003ec\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 14.26%;border: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e4.65\u0026plusmn;0.14\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.92%;border:none;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e14.50\u0026plusmn;0.91\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 17.38%;border: none;padding: 0in 1.4pt;height: 1pt;vertical-align: top;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e10.87\u0026plusmn;0.44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:20.9%;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cem\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eP-\u003c/span\u003e\u003c/em\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003evalue\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.92%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.145\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.62%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:red;'\u003e0.018\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:14.26%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.251\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.92%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.119\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:17.38%;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 1.4pt 0in 1.4pt;height:1.0pt;\"\u003e\n \u003cp style='margin-top:0in;margin-right:0in;margin-bottom:0in;margin-left:0in;text-align:center;text-indent:0in;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:13.0pt;'\u003e\u003cspan style='font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e0.206\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.15pt;margin-left:0in;text-align:justify;text-indent:0in;line-height:95%;font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003eData in shown as \u0026ldquo;Mean \u0026plusmn; SE\u0026rdquo;.\u0026nbsp;Data in the same column with different lowercase letters on the shoulders indicate significant differences (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05).\u003c/p\u003e\n\u003cp style='margin-top:0in;margin-right:0in;margin-bottom:8.15pt;margin-left:0in;text-align:justify;text-indent:0in;line-height:95%;font-size:13px;font-family:\"Palatino Linotype\",serif;color:black;'\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e7. Effect of Presence/Absence of ACACB Haplotypes on Milk Quality\u003c/p\u003e\n\u003cp\u003eThe effects of the presence and absence of \u003cem\u003eACACB\u003c/em\u003e haplotypes on milk quality traits are shown in Table 10. It can be seen that the percentage of milk fat in individuals carrying haplotype H2 was significantly greater than that in individuals with the deletion (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05), while the total solid content in individuals carrying haplotypes H2 and H4 was significantly lower than that of individuals with the deletion (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05). The results showed that the presence of haplotype H2 resulted in higher milk fat contents, while the presence of haplotypes H2 and H4 led to lower contents; differences in the presence or absence of the other haplotypes were not significant (\u003cem\u003eP\u003c/em\u003e\u0026gt;0.05).\u003c/p\u003e\n\u003cp\u003e\u003cimg 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\" style=\"width: 631px; height: 573.785px;\" width=\"631\" height=\"573.785\"\u003e\u003cbr\u003e\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003e1. Genetic Characterization of ACACB in the Gannan Yak\u003c/p\u003e\n\u003cp\u003eThe present study investigated, for the first time, the relationship between genetic variation in three different regions of \u003cem\u003eACACB\u003c/em\u003e in the Gannan yak and milk quality traits and fatty acid contents. Correlation analysis showed that the polymorphic loci SNP1, SNP3, SNP5, SNP6, and SNP7 genotypes of \u003cem\u003eACACB\u003c/em\u003e were significantly correlated with the fatty acid contents, milk fat percentages, lactose contents, milk protein percentages, total solid contents, and C11:0, C18:0, and C20:3n8C contents in the milk of Gannan yaks. SNP3 and SNP4 were significantly associated with the fatty acid contents of milk fat, including SFA and MUFA. Han et al. observed the variant locus g.66218726 T\u0026gt;C in \u003cem\u003eACACB\u003c/em\u003e of Chinese Holstein cows to be significantly associated with both milk yield and fat content\u003csup\u003e20\u003c/sup\u003e. Genetic variation in intron 18 of \u003cem\u003eACACB\u003c/em\u003e has been found to be associated with obesity and kidney disease in humans\u003csup\u003e22,23\u003c/sup\u003e. These findings indicate that there is considerable polymorphism in the \u003cem\u003eACACB\u003c/em\u003e gene in both humans and livestock species, and it is hypothesized that the SNP loci identified in the present study may be functional, although further confirmation is needed.\u003c/p\u003e\n\u003cp\u003ePIC and He are indicators of the degree of genetic variation within a population, with the magnitude of their values reflecting the overall level of genetic variation in the population; the larger the value, the richer the genetic diversity and the greater the potential for selection\u003csup\u003e24\u003c/sup\u003e. Among the seven SNP loci investigated in this study, the SNP 1, 2, 5, and 6 loci showed low polymorphism (PIC\u0026le;0.25), SNP3, while the SNP4 and SNP7 loci were moderately polymorphic (0.25\u0026lt;PIC\u0026lt;0.5), suggesting that these seven SNP loci may be suitable for analyzing linkages between traits and genetic markers.\u003c/p\u003e\n\u003cp\u003e2. ACACB Gene Polymorphisms Affect Milk Quality Traits and Fatty Acid Contents in the Gannan Yak\u003c/p\u003e\n\u003cp\u003eThe findings showed that genetic variation at the SNP 1, 2, 3, 5, and 7 loci in the \u003cem\u003eACACB\u0026nbsp;\u003c/em\u003egene was significantly correlated with milk quality traits in Gannan yaks. The \u003cem\u003eACACB\u003c/em\u003e gene, as a new candidate gene for genetic markers of milk improvement, encodes an enzyme involved in lipid metabolism, that is mainly expressed in tissues associated with high energy production, such as skeletal muscle, the myocardium, and liver. The enzyme is expressed on the outer mitochondrial membrane close to CTP1, where it functions as a negative regulator of fatty acid oxidation\u003csup\u003e25,26\u003c/sup\u003e. ACACA (acetyl coenzyme A carboxylase alpha), an isoform of ACACB, is an enzyme that regulates fatty acid synthesis and is traditionally regarded as a major regulator of the rate-limiting step in de novo lipogenesis\u003csup\u003e27\u003c/sup\u003e. It has been shown that ACACA var-iants significantly affect milk production traits in both dairy goats and cows\u003csup\u003e27-29\u003c/sup\u003e. The \u003cem\u003eACACB\u003c/em\u003e gene is located in a region known to significantly influence both milk yield and milk composition\u003csup\u003e30\u003c/sup\u003e. The \u003cem\u003eACACB\u003c/em\u003e gene SNP g.66218726 T\u0026gt;C significantly affects several milk production traits such as milk yield and fat content\u003csup\u003e20\u003c/sup\u003e. It was thus hy-pothesized that \u003cem\u003eACACB\u003c/em\u003e genetic variants may affect quality traits in yak milk.\u003c/p\u003e\n\u003cp\u003eAlthough a literature search did not find publications on polymorphisms in \u003cem\u003eACACB\u003c/em\u003e in yaks, several studies have suggested that the gene is associated with traits related to fat metabolism in cattle. In human studies, \u003cem\u003eACACB\u003c/em\u003e genetic variants have been associated with metabolic syndrome, the onset of type II diabetes, kidney disease, and obesity in postmenopausal women\u003csup\u003e23,31,32\u003c/sup\u003e. In pigs, \u003cem\u003eACACB\u003c/em\u003e was shown to be associated with lipid metabolic processes and obesity in Meishan pigs\u003csup\u003e33\u003c/sup\u003e. The fatty acid contents of milk have been found to be heritable and have heritability estimates of 0.22 to 0.71\u003csup\u003e34\u003c/sup\u003e. In the present study, it was found that genetic variants at SNPs 1, 2, 3, and 4 in \u003cem\u003eACACB\u003c/em\u003e were significantly associated with the contents of fat and different types of fatty acids in the milk of Gannan yaks. It was, therefore, hypothesized that variations in \u003cem\u003eACACB\u003c/em\u003e may affect the compositions of milk fat and fatty acids through the regulation of fat mobilization.\u003c/p\u003e\n\u003cp\u003eSNPs are defined as substitutions, insertions, or deletions of single nucleotides and are important in animal breeding\u003csup\u003e35\u003c/sup\u003e. Determining the correlation between the loci of candidate SNPs and the economic traits of animals is an effective method for identifying new genetic markers, facilitating the accurate and efficient analysis of genetic diversity in breeding programs\u003csup\u003e36,37\u003c/sup\u003e. Protein function and gene expression are associated with the location of the SNP, whether in regulatory sequences or coding regions\u003csup\u003e38\u003c/sup\u003e. Exons, as protein-coding regions, make up only 1-2% of the genome, and the mutation rate of exons is about one-fifth that of non-coding regions\u003csup\u003e39\u003c/sup\u003e. Studies have shown that a SNP in exon 2 of the growth hormone (\u003cem\u003eGH)\u003c/em\u003e gene (SNP: c.100A\u0026gt;G) can be a useful marker in the selection of dairy goat breeds for growth and milk characteristics\u003csup\u003e40\u003c/sup\u003e. Polymorphisms in exons 7 and 12 of the lactoferrin gene have been associated with the incidence of mastitis in Mora buffaloes\u003csup\u003e41\u003c/sup\u003e while polymorphisms in exon 3 of leptin (\u003cem\u003eLEP)\u003c/em\u003e affect milk production traits in New Zealand Holstein-Friesian\u0026thinsp;\u0026times;\u0026thinsp;Jersey-cross dairy cows\u003csup\u003e42\u003c/sup\u003e and polymorphisms in exons 2 and 5 and introns 1 and 2 of prolactin (\u003cem\u003ePRL)\u003c/em\u003e affect milk production traits in Italian Mediterranean river buffalo\u003csup\u003e43\u003c/sup\u003e. In the present study, two SNPs (SNP1 and SNP4) were detected in exons 37 and 46, respectively, of the \u003cem\u003eACACB\u003c/em\u003e gene in Gannan yaks, and were significantly correlated with the protein, lactose, and fatty acid contents of yak milk. These results were essentially consistent with those of previous studies but since there are fewer studies on \u003cem\u003eACACB\u003c/em\u003e genetic mutations and milk quality traits, the effects of these mutations on milk quality traits in the yak require further verification.\u003c/p\u003e\n\u003cp\u003eThere is increasing evidence showing that introns are important for the normal expression of many eukaryotic genes. Introns have a wide range of functions and are involved in almost every step of the mRNA process. Although intronic variation may not directly affect the structure of a gene, it can influence transcription efficiency by affecting regulatory elements such as enhancers or other DNA structures\u003csup\u003e44\u003c/sup\u003e.\u0026nbsp;SNPs located in introns are also highly functional compared to those located in exons. Although introns lack coding ability, they can regulate gene expression\u003csup\u003e45\u003c/sup\u003e and introns in several genes have been shown to have normal transcription rates\u003csup\u003e46\u003c/sup\u003e. While it is well known that intronic mutations do not alter the amino acid sequence, it has been found that mutations located in introns may have similar effects to those of synonymous mutations, and that the occurrence of intronic mutations affects a number of economically important traits in animals. For example, the intronic region of the GTPase-activating protein-encoding \u003cem\u003eRAP1GAP\u003c/em\u003e gene in lake sheep, g.13561 G\u0026gt;A, and the intronic region of the amino acid-transporting protein-encoding \u003cem\u003erBAT\u003c/em\u003e gene, g.1460 T\u0026gt;C, were significantly correlated with traits associated with caudal fat deposition in the sheep\u003csup\u003e47\u003c/sup\u003e. Amills et al. showed that the T to C substitution in intron 16 of the goat diacylglycerol O-acyltransferase-encoding \u003cem\u003eDGAT1\u003c/em\u003e gene had a significant effect on milk traits in goats and could be used as a marker for research\u003csup\u003e48\u003c/sup\u003e. In addition, in the pre-sent study, it was found that introns 37, 46, and 47 of \u003cem\u003eACACB\u003c/em\u003e were mutated and correlated with milk quality traits such as milk fat and lactose contents, as well as the content of different types of milk fat fatty acids in Gannan yaks. This is essentially consistent with the findings of other studies and it was hypothesized that intronic variants in \u003cem\u003eACACB\u003c/em\u003e had a regulatory effect on milk production in yaks. Therefore, it is hypothesized that intronic variants may affect economically important traits in yaks.\u003c/p\u003e\n\u003cp\u003eIn conclusion, mutations in \u003cem\u003eACACB\u003c/em\u003e have an important effect on yak milk quality traits, milk fat percentages, and fatty acid contents, indicating that \u003cem\u003eACACB\u003c/em\u003e and its genetic variants may be involved in fatty acid metabolism pathways which, in turn, regulate lipid metabolism and lead to changes in milk fat traits. However, further verification is required.\u003c/p\u003e\n\u003cp\u003e3. ACACB Gene Haplotypes and Diplotypes Affect Milk Quality and Fatty Acid Contents in Gannan Yaks\u003c/p\u003e\n\u003cp\u003eTo assess the effects of the SNPs on milk quality traits, this study applied a model for the association analysis of haplotypes and diplotypes and milk quality traits. Hap-lotypes are inherited more efficiently than individual SNPs\u003csup\u003e49\u003c/sup\u003e. The effect of a gene on an organism\u0026apos;s traits may be related to different diplotypes of SNP sites in that gene\u003csup\u003e50\u003c/sup\u003e. Liu et al. found that the melanocortin-4 receptor gene Hap1/4 diplotypes (ACC-ATG) were more strongly associated with carcass quality traits than other diplotypes in a Chinese indigenous beef cattle breed\u003csup\u003e51\u003c/sup\u003e. Gui et al. reported the individuals carrying Hap5/5 diplotypes (CC-GG-GG-GG-CC) of the hormone-sensitive lipase (\u003cem\u003eHSL\u003c/em\u003e) gene in Chinese cattle breeds had greater levels of intramuscular fat content compared with other diplotypes\u003csup\u003e52\u003c/sup\u003e. Genetic variation in the promoter region of LAP3 dairy cows with the diplotype H1H3 (CTACGCT/GCGTACG) is associated with higher levels of lactation relative to other diplotypes\u003csup\u003e53\u003c/sup\u003e. Studies on genetic variation in the prolactin gene in Holstein dairy cattle showed that the H2H8 diplotype was significantly asso-ciated with milk production traits\u003csup\u003e54\u003c/sup\u003e. Perna et al. found that \u0026beta;-\u0026kappa;-casein (CN) haplo-types A1A, A1B, A1E, A2A, and A2B were associated with milk yield and fat content in Ayrshire dairy cows in Finland\u003csup\u003e55\u003c/sup\u003e. The results of the present study revealed that the highest milk fat rate was associated with the H2H2 diplotype of the \u003cem\u003eACACB\u003c/em\u003e gene in Gannan yaks, which was significantly higher than other diplotypes; the milk fat con-tents of the milk from individuals carrying haplotype H2 were significantly higher than that in individuals with the deletion, and the total solid contents in individuals carrying haplotypes H2 and H4 were significantly lower than those of individuals with the deletion. This may be due to the fact that the \u003cem\u003eACACB\u003c/em\u003e gene and its SNPs affect fat mobilization by influencing the fatty acid oxidation pathway to regulate both milk quality and milk fat fatty acid contents, although the specific regulatory mechanism requires further investigation to determine the link between genetic variation and milk quality.\u003c/p\u003e"},{"header":"Materials and Methods","content":"\u003cp\u003e1. Animals and Sample Collection\u003c/p\u003e\n\u003cp\u003eBlood samples (10 mL) were collected from the jugular veins of 202 female Gannan yaks with calves; all yaks had had three litters and were at the same stage of lactation. The blood was collected into anticoagulant citrate dextrose solution (Acid-Citrate-Dextrose, ACD) and was brought back to the laboratory and frozen at -70℃ before genomic DNA extraction.\u003c/p\u003e\n\u003cp\u003eThe animal study was approved by the Animal Care Committee at Gansu Agricultural University (approval number GAU-LC-2020-056). All animals in this study were approved by the Animal Ethics Committee of Gansu Agricultural University (approval number 2006-398).\u0026nbsp;All methods were performed in accordance with the relevant guidelines and regulations.\u003c/p\u003e\n\u003cp\u003eThe age, group, and litter size of all yaks from which blood samples were collected were recorded, and milk samples (25 mL) were collected once in the morning and once in the evening for three consecutive days. The samples were transferred to the laboratory on ice for the evaluation of milk quality characteristics.\u003c/p\u003e\n\u003cp\u003e2. Methods\u003c/p\u003e\n\u003cp\u003e2.1. Determination of milk quality traits\u003c/p\u003e\n\u003cp\u003eThe milk samples were sent to the Quality Supervision, Inspection and Testing Center for Animal Hides and Skins and Products of the Ministry of Agriculture (Lanzhou, China) for trait analysis using a FOSS Milk Composition Analyzer (FOSS, Hiller\u0026oslash;d, Denmark). The traits analyzed included the levels of lactose, milk protein, and milk fat, and the contents of total solids and non-fat solids.\u003c/p\u003e\n\u003cp\u003e2.2. Extraction of genomic DNA\u003c/p\u003e\n\u003cp\u003eGenomic DNA was extracted from the yak blood using a Whole-Genome Blood DNA Extraction Kit (Centrifugal Column Type), according to the manufacturer\u0026rsquo;s instructions, and the DNA integrity, purity and concentration were evaluated by 1.5% agarose gels and spectrophotometry, using a NanoDropTM Lite spectrophotometer (Thermo Fisher, Waltham, MA, USA), and stored at -20℃ until use.\u003c/p\u003e\n\u003cp\u003e2.3. Primer design and synthesis\u003c/p\u003e\n\u003cp\u003ePrimers were designed according to the yak \u003cem\u003eACACB\u003c/em\u003e sequence provided in the Ensembl database (ENSBMUG00000022222) using Primer Premier 5.0 software and the primer information is referenced in that literature\u003csup\u003e21\u003c/sup\u003e.\u0026nbsp;The primers were synthesized by Beijing Kengke Biological Company (Xi\u0026apos;an, China).\u003c/p\u003e\n\u003cp\u003e2.4. Detection of SNP loci by PCR amplification and hybrid pool sequencing\u003c/p\u003e\n\u003cp\u003eThe total volume of the PCR reaction was 20 \u0026mu;L and included 0.8 \u0026mu;L of each of the upstream and downstream primers, 0.8 \u0026mu;L of genomic DNA, 10.0 \u0026mu;L of Taq DNA polymerase, and 7.6 \u0026micro;L of ddH\u003csub\u003e2\u003c/sub\u003eO. The PCR reaction conditions were pre-denaturation at 94 ℃ for 5 min, denaturation at 94 ℃ for 30 s, annealing at 60 ℃ for 30 s, extension at 72 ℃ for 30 s (35 cycles), and extension at 72 ℃ for 10 min. The PCR products were preserved at 4 ℃. Two microliters of the PCR amplification products from each of the 20 blood samples of the unrelated yaks were removed, and the mixed products to form a mixed pool. And then sent to Beijing Kengke Biological Company for sequencing.\u003c/p\u003e\n\u003cp\u003e2.5. Determination of genotype\u003c/p\u003e\n\u003cp\u003eThe genomic DNA samples were sent to King Peptide Biologicals (Wuhan, China) for typing and determination of their genotypes using the KASP method.\u003c/p\u003e\n\u003cp\u003e3. Statistics and Data Analysis\u003c/p\u003e\n\u003cp\u003eMicrosoft Excel 2016 was used to collate the data, and the genotype frequency and allele frequency, observed homozygosity (Ho), number of effective alleles (Ne), heterozygosity (He), and polymorphic information content (PIC) were calculated. Linkage disequilibrium and haplotypes of the SNPs were analyzed using SHEsis software (http://analysis.biox.cn/myAnalysis.php). Genotypes, haplotypes, and diplotypes of SNPs were analyzed to determine associations with milk quality traits using a general linear model (GLM) with SPSS 26.0 software. The statistical model was as follows: \u003cem\u003eY\u003csub\u003eijk\u003c/sub\u003e\u003c/em\u003e=\u003cem\u003e\u0026mu;\u003c/em\u003e+\u003cem\u003eGenotype\u003csub\u003ei\u003c/sub\u003e\u003c/em\u003e/\u003cem\u003eHaplotype\u003csub\u003ei\u003c/sub\u003e\u003c/em\u003e+\u003cem\u003eParity\u003csub\u003ej\u003c/sub\u003e\u003c/em\u003e+\u003cem\u003eGroup\u003csub\u003ek\u003c/sub\u003e\u003c/em\u003e+\u003cem\u003ee\u003csub\u003eijk\u003c/sub\u003e,\u0026nbsp;\u003c/em\u003ewhere \u003cem\u003eY\u003csub\u003eijk\u003c/sub\u003e\u003c/em\u003e represents the phenotypic observation; \u003cem\u003e\u0026micro;\u003c/em\u003e represents the population mean;\u003cem\u003e\u0026nbsp;Genotype\u003c/em\u003e represents the fixed effect of genotype; \u003cem\u003eHaplotype\u003c/em\u003e represents the fixed effect of haplotype; \u003cem\u003eParity\u003csub\u003ej\u003c/sub\u003e\u003c/em\u003e represents the fixed effect of litter size; \u003cem\u003eGroup\u003csub\u003ek\u003c/sub\u003e\u003c/em\u003e represents the fixed effect of population; \u003cem\u003ee\u003csub\u003eijk\u003c/sub\u003e\u003c/em\u003e represents the random error.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eIn this study, the influence of genetic variants in the \u003cem\u003eACACB\u003c/em\u003e gene on yak milk quality traits was investigated for the first time. Potential functional mutations in \u003cem\u003eACACB\u003c/em\u003e were identified, which can be used as molecular markers for the selection and breeding of yaks yielding high-quality milk, and provide a reference for an in-depth investigation on the influence of the yak \u003cem\u003eACACB\u003c/em\u003e gene on yak milk quality traits.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eData Availability:\u0026nbsp;\u003c/strong\u003eData are contained within the article. The sequences data in our study has been uploaded to the NCBI gene bank and GenBank accession number are as follows:\u0026nbsp;BankIt2726640 Sequence_1\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;OR348640; BankIt2726640 Sequence_2\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;OR348641; BankIt2726640 Sequence_3\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;OR348642; BankIt2726640 Sequence_4\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;\u0026nbsp;OR348643; BankIt2726640 Sequence_5\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;OR348644; BankIt2726640 Sequence_6\u0026nbsp;OR348645; BankIt2726640 Sequence_7\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;OR348646; BankIt2726640 Sequence_8\u0026nbsp;OR348647.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatement:\u0026nbsp;\u003c/strong\u003eThis study was reported in accordance with ARRIVE guidelines (https://arriveguidelines.org/).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003cstrong\u003e:\u0026nbsp;\u003c/strong\u003eWe give thanks all participants for their advice and support of this study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor Contributions:\u003c/strong\u003e Conceptualization, X.W. methodology, Y.Q.; software, B.M.; validation, C.C.;\u0026nbsp;formal analysis, S.C.; investigation, Y.Q. and C.Z.; resources, Z.Z.; data curation, F.Z.; writing\u0026mdash;original draft preparation, C.Z.; writing\u0026mdash;review and editing, X.L.; visualization, J.W. and Z.H.; project administration, B.S.; funding acquisition, J.H. All authors have read and agreed to the published version of\u0026nbsp;the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding:\u003c/strong\u003e This study was supported by the \u0026ldquo;Gansu Agricultural University Public Recruitment Doctoral Research Start-up Fund (GAU-KYQD-2020-20)\u0026rdquo;, \u0026ldquo;Gansu Provincial Department of Education: Industrial Support Plan Project (2022CYZC-43)\u0026rdquo;, \u0026ldquo;Discipline Team Project of Gansu Agricultural University (GAU-XKTD-2022-22)\u0026rdquo;.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting\u0026nbsp;interests:\u0026nbsp;\u003c/strong\u003eThe authors declare no competing interests.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eShah, A. M., Bano, I., Qazi, I. 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The influence of casein haplotype on quality, coagulation, and yield traits of milk from Italian Holstein cows. \u003cem\u003eJournal of Dairy Science\u003c/em\u003e, doi:10.3168/jds.2015-10463 (2016).\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-3893649/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3893649/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eAcetyl-CoA carboxylase beta (ACACB) is a rate-limiting enzyme involved in lipid syn-thesis and fatty acid oxidation. The results of our previous study showed that a total of seven SNPs were detected in the exon 37-intron 37, exon 46-intron 46, and intron 47 regions of the yak ACACB, and mutations in the ACACB were found to affect yak meat quality traits. However, the genetic effects of ACACB on yak milk quality traits have not been reported. Therefore, the aim of this study was to investigate the effects of ACACB polymorphisms on yak milk quality traits in Gannan yaks. In this study, A total of 202 Gannan yaks were included in the study. Analyze the different geno-types, diplotypes, and the presence or absence of haplotypes on milk quality. The seven SNPs were named as exon 37-intron 37 (exon 37: SNP1, intron 37: SNP2 and SNP3), exon 46-intron 46 (exon 46: SNP4, intron 46: SNP5), and intron 47 (SNP6 and SNP7). Apart from the SNP1, SNP2, SNP5, and SNP6 loci where the polymorphic information content (PIC) was low (PIC ≤ 0.25), the SNP3, SNP4, and SNP7 loci were all of intermediate polymorphic information status (0.25 \u0026lt; PIC \u0026lt; 0.5). The highest frequency of heterozygosity occurred at the SNP7 locus, and the two alleles were evenly distributed in the population compared to alleles at the other loci. There were no strong linkages between the SNPs (r\u003csup\u003e2\u003c/sup\u003e\u0026lt;0.33) except for a strong linkage disequilibrium observed between SNP1 and SNP2 (r\u003csup\u003e2\u003c/sup\u003e=0.89). Seven effective haplotypes and seven diplotypes were constructed for the Gannan yak ACACB gene. Correlation analysis showed that SNP1 and SNP7 were associated with lactose content (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05), while SNP3 was significantly associated with the protein and monounsaturated fatty acid contents in the milk (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05). SNP4 was significantly associated with both saturated and monounsaturated fatty acid contents (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05 and \u003cem\u003eP\u003c/em\u003e\u0026lt;0.01, respectively), while SNPs 5 and 7 were significantly correlated with the fat percentage (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05) and SNP6 was significantly correlated with total solid content of the milk (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05). Yaks with the H2H2 diplotype had significantly higher levels of milk fat than other diplotypes (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05) while milk fat contents in animals carrying hap-lotype H2 were significantly higher than that in yaks carrying the deletion type (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05). The findings of the present study suggest that polymorphisms in the yak ACACB affect milk quality and can be used as genetic markers for enhancing milk quality in yak populations. The findings provide a theoretical basis for the genetic characterization of milk quality traits in the Gannan yak.\u003c/p\u003e","manuscriptTitle":"Polymorphisms of ACACB Gene and Their Association with Milk Quality Traits in Yak","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-02-28 09:07:32","doi":"10.21203/rs.3.rs-3893649/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"3006bdc7-308f-42db-9768-deb62e5ae04e","owner":[],"postedDate":"February 28th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":28970930,"name":"Biological sciences/Biological techniques"},{"id":28970931,"name":"Biological sciences/Genetics"},{"id":28970932,"name":"Biological sciences/Molecular biology"}],"tags":[],"updatedAt":"2025-02-19T05:38:38+00:00","versionOfRecord":[],"versionCreatedAt":"2024-02-28 09:07:32","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3893649","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3893649","identity":"rs-3893649","version":["v1"]},"buildId":"_2-kVJe1T_tPrBINL-cwx","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}