Experimental Study on Anti-Endometriosis of wenjing Yiweikang Granule

To investigate the therapeutic effect of Wenjingyiweikang keli on endometriosis and dysmenorrhea. The rat endometriosis model was produced by surgery, we observed the change of uterus tissue morphology, the antibody level of antiendometrium and the serum level of estradiol, progesterone and PGF_(2#alpha#). The effect on uterus activation, inflammation and pain was also observed. Wenjingyiweikang keli could inhibit the endometriosis of rat, reduced the antibody level of antiendometrium, decreaser the level of estradiol, progesterone and PGF_(2#alpha#) nserum(p< 0. 01).Through pathological observation, the glands and glandular epithelium of abnormal endometrium were obviously withered, the effectwas dose dependent, sim ilar to Danazol. The uterus constriction of rat in vitro and of rbbit in vivo was both inhibited. In vitro, the range, the frequency and the tension of the constriction were decreased, the effectwas dose dependent, while in vivo, only the tension of the constriction was inhibited. So did the uterus constriction produce by oxytocin and ergotocine, and the effect was stronger than the effect of Yueyueshu and Danazol. The growth of ovary and folliculus were not effected. The eggwhite-induced paw swelling of rat and the xylene-induced auricular swelling of m ouse were inhibited. The mousetwisting induced by acetic acid was not influenced, either. The normalimmune system of rat was not influenced.