Basal cells in the epidermis and epidermal differentiation

Basal cells in the epidermis and epidermal differentiation | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Basal cells in the epidermis and epidermal differentiation Raghvendra Singh This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-668420/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract A definite identification of epidermal stem cells is not known and the mechanism of epidermal differentiation is not fully understood. Toward both of these quests, considerable information is available from the research on lineage tracing and clonal growth analysis in the basal layer of the epidermis, on the hair follicle and interfollicular epidermal stem cells, and on Wnt signaling along with its role in developmental patterning and cell differentiation. In this paper, literature on the aforementioned research has been collated and analyzed. In addition, models of basal layer cellular composition and epidermal differentiation have been presented. Stem Cell & Developmental Cell Biology Epidermal stem cells Basal cells Epidermal differentiation Stem cells Full Text Supplementary Files Supplementaryinformation.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-668420","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":36173918,"identity":"18e6096d-b5c9-4ed4-a239-9a6b7f886cac","order_by":0,"name":"Raghvendra Singh","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA1ElEQVRIiWNgGAWjYHACNhDB2M/M2MDYAGIyE6tlZjNjYyNpWjYcYGCEaCEEzNuPX3vMU3FHdvNx5vaHMxjs5BnYeQ/g1SJzJqfcmOfMM+Nth4EO28CQbNjAzJeAV4sEQ06a5My2w4lgLQ8YmBMYmHkM8GvhfwPU8u9w4uZmsJZ6IrRIpB+T+NhwOHEDM9hhh4nR8oZN4sOxw8YzgA6bOcPguGEbYYelP5NIqDks299//MHHnopqeX7+M/i1MDCgmGkAjSb8gP0BYTWjYBSMglEwsgEA6/BEVGdYFkwAAAAASUVORK5CYII=","orcid":"","institution":"Indian Institute of Technology Kanpur","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Raghvendra","middleName":"","lastName":"Singh","suffix":""}],"badges":[],"createdAt":"2021-06-29 04:36:36","currentVersionCode":1,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":true,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false,"coiExplicitlySet":false},"doi":"10.21203/rs.3.rs-668420/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-668420/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":13652391,"identity":"d0cdfdaa-2613-4687-9d96-ef0777873be6","added_by":"auto","created_at":"2021-09-17 09:49:24","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":423154,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-668420/v1_covered.pdf"},{"id":10927158,"identity":"543aafba-f1ea-4701-bbd5-db5d2f7c7c20","added_by":"auto","created_at":"2021-06-29 20:15:18","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":419380,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-668420/v1_covered.pdf"},{"id":10927009,"identity":"78b28966-0169-450b-a10d-197c0ac7b989","added_by":"auto","created_at":"2021-06-29 20:12:07","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":162601,"visible":true,"origin":"","legend":"","description":"","filename":"Supplementaryinformation.pdf","url":"https://assets-eu.researchsquare.com/files/rs-668420/v1/88da14f1870ec65a74f806c4.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eBasal cells in the epidermis and epidermal differentiation\u003c/p\u003e\u003cp\u003e\u003cbr\u003e\u003c/p\u003e","fulltext":[{"header":"Full Text","content":"This preprint is available for \u003ca href='/article/rs-668420/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"Indian Institute of Technology Kanpur","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Epidermal stem cells, Basal cells, Epidermal differentiation, Stem cells","lastPublishedDoi":"10.21203/rs.3.rs-668420/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-668420/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eA definite identification of epidermal stem cells is not known and the mechanism of epidermal differentiation is not fully understood. 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