Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health.

Citrus, which has been consumed internationally for a long time, is widely used as a health food. Citrus and its active components exert significant effects on oxidative stress and lipid metabolism, which are closely associated with female reproductive health. Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Sirtuin 1 (SIRT1), and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptor α (PPARα). This review focuses on the effects of Citrus on oxidative stress and lipid metabolism, aiming to provide new insights for promoting female reproductive health; however, further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of Citrus’s bioactive components in clinical settings. 摘要 柑橘在国际上拥有悠久的食用历史, 广泛被用作健康食品。 柑橘及其活性成分对氧化应激和脂质代谢具有显著的调节作用, 这些因素与女性生殖健康密切相关。 研究表明, 柑橘来源的化合物可能通过激活 Nrf2 和 SIRT1 等信号通路缓解氧化应激, 并通过激活包括 PPARα 在内的信号通路改善脂质代谢。 本文综述了柑橘对氧化应激和脂质代谢的影响, 旨在为促进女性生殖健康提供新思路。 然而, 仍需进一步的研究明确其作用机制, 且柑橘活性成分的临床治疗潜力仍有待验证。 Similar content being viewed by others

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Phytomedicine, 130:155560. https://doi.org/10.1016/j.phymed.2024.155560 Acknowledgments This work was supported by the National Natural Science Foundation of China (No. 82374510) and the General Scientific Research Project of the Education Department of Zhejiang Province (No. Y202455593), China. Author information Authors and Affiliations Contributions Jue ZHOU determined the topic of the article, proposed this program, and reviewed and revised the manuscript. Yiyan YANG collected the literature, wrote the manuscript, and summarized and drew the tables and figure. Both authors have read and approved the final manuscript. Corresponding author Ethics declarations Yiyan YANG and Jue ZHOU declare that they have no conflicts of interest. This article does not contain any studies with human or animal subjects performed by either of the authors. Rights and permissions About this article Cite this article Yang, Y., Zhou, J. Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health. J. Zhejiang Univ. Sci. B 26, 763–777 (2025). https://doi.org/10.1631/jzus.B2500127 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1631/jzus.B2500127