VEGF、HIF-1α在子宫内膜异位症中的表达及意义
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Abstract
目的探讨血管内皮生长因子（vascular endothelial cell growth factor，VEGF）、缺氧诱导因子-1α（hypoxia inducible factor-1，HIF-1α）在子宫内膜异位症（endometriosis，EM）的表达及意义。方法采用免疫组织化学S-P法分别检测VEGF、HIF-1α蛋白在EM在位、异位内膜和正常子宫内膜组织中的表达。结果EM组织中VEGF、HIF-1α的表达较正常组内膜明显增高（P〈0．01），且HIF—1α与VEGF在EM组织中的表达呈正相关关系。结论VEGF和HIF—1α在EM中过度表达，推测VEGF、HIF-1α与EM的发病密切相关。
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- last seen: 2026-06-10T17:14:06.276822+00:00
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