Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients

J L Coloma, Martínez-Zamora, D Tàssies, J C Reverter, G Espinosa, R Cervera, F Carmona
Journal of reproductive immunology · 2023 · vol. 156 , pp. 103827 · doi:10.1016/j.jri.2023.103827 · PMID:36773494
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Deep endometriosis patients showed significantly higher antinuclear antibody positivity and more arthralgia and asthenia compared to non-deep endometriosis patients and healthy controls.

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The study evaluated the systemic lupus erythematosus (SLE) serological autoimmune antibody profile in four groups of premenopausal participants: deep endometriosis (DE, n=50), non-deep endometriosis with ovarian endometriomas (Non-DE, n=50), healthy controls without endometriosis (C, n=45), and SLE patients without endometriosis (SLE group, n=46). Using blood samples and the standard SLE antibody profile, the authors found that the DE group had a statistically significant higher proportion of antinuclear antibodies (ANA) positivity (20%) compared with Non-DE (4%) and controls (2.2%); complement reductions were more frequent in both DE and Non-DE but were not statistically significant, and anti-dsDNA and anticoagulant lupus were more frequent in DE without reaching statistical significance. DE participants also reported more arthralgia and asthenia than Non-DE and controls. The paper therefore identifies increased ANA positivity and generalized pain symptoms in DE but does not establish statistically significant differences for several other SLE markers, limiting conclusions about a broader autoimmune shift. This paper is centrally about endometriosis — it compares SLE autoantibody profiles between deep and non-deep endometriosis patients.

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Abstract

OBJECTIVE: Several studies have reported a high prevalence of autoimmune diseases such as systemic lupus erythematosus (SLE) in endometriosis patients. The aim of this study was to evaluate the SLE autoimmune antibody profile in patients with deep (DE) and non-deep endometriosis (Non-DE). MATERIALS AND METHODS: Four groups of premenopausal patients were evaluated: patients with DE (n = 50); patients with ovarian endometriomas (Non-DE; n = 50); healthy patients without endometriosis (C group; n = 45); and SLE patients without endometriosis (SLE group; N = 46). Blood samples were obtained and the standard SLE autoimmune profile was evaluated in all patients. Pain symptoms related to endometriosis and clinical SLE manifestations were also recorded. RESULTS: The DE group presented a statistically significant higher proportion of patients with antinuclear antibodies (ANA) (20%) compared to the Non-DE group (4%) and C group (2.2%). Levels of complement were more frequently lower among DE and Non-DE patients although differences did not reach statistical significance. Similarly, anti-dsDNA antibodies and anticoagulant lupus were positive in more patients of the DE group but did not reach statistical significance. The DE group complained of more arthralgia and asthenia compared to the Non-DE and C groups. CONCLUSIONS: The results of this study showed higher positivity of ANA and greater arthralgia and asthenia in patients with DE compared with Non-DE patients and healthy controls, suggesting that they may have a higher susceptibility to autoimmune diseases and present more generalized pain.
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Document type ArticleVersion Published versionPublication date Publication license Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/207223 Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients Journal Title Director/Tutor Journal ISSN Volume Title Related resource Abstract Several studies have reported a high prevalence of autoimmune diseases such as systemic lupus erythematosus (SLE) in endometriosis patients. The aim of this study was to evaluate the SLE autoimmune antibody profile in patients with deep (DE) and non-deep endometriosis (Non-DE).Four groups of premenopausal patients were evaluated: patients with DE (n = 50); patients with ovarian endometriomas (Non-DE; n = 50); healthy patients without endometriosis (C group; n = 45); and SLE patients without endometriosis (SLE group; N = 46). Blood samples were obtained and the standard SLE autoimmune profile was evaluated in all patients. Pain symptoms related to endometriosis and clinical SLE manifestations were also recorded.The DE group presented a statistically significant higher proportion of patients with antinuclear antibodies (ANA) (20%) compared to the Non-DE group (4%) and C group (2.2%). Levels of complement were more frequently lower among DE and Non-DE patients although differences did not reach statistical significance. Similarly, anti-dsDNA antibodies and anticoagulant lupus were positive in more patients of the DE group but did not reach statistical significance. The DE group complained of more arthralgia and asthenia compared to the Non-DE and C groups.The results of this study showed higher positivity of ANA and greater arthralgia and asthenia in patients with DE compared with Non-DE patients and healthy controls, suggesting that they may have a higher susceptibility to autoimmune diseases and present more generalized pain.Copyright © 2023. Published by Elsevier B.V. Subject Subject (English) Citation Citation COLOMA, José Luis, et al. Serological autoimmune profile of systemic lupus erythematosus in deep and non-deep endometriosis patients. Journal Of Reproductive Immunology. 2023. Vol. 156, num. 103827. ISSN 0165-0378. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/207223

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endometriosis

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Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases Autoimmune Diseases

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