A Rare Case Report of Primary Ovarian Burkitt Lymphoma and Review of Literature

Background: Primary ovarian Burkitt lymphoma is rare, with only 26 reported cases，usually with high proliferative activity and MYC translocation. A case of primary ovarian Burkitt lymphoma that occurred in a 25-year-old woman was described in the present study. Case presentation: An ultrasound examination indicated that the right ovary was enlarged and abundant blood flow signals were observed. The right salpingo-oophorectomy was subsequently performed. Histology was characterized by diffuse sheets of monotonous medium-sized lymphoid cells with high mitotic activity and apoptosis. Numerous tangible-body macrophages were found in the ovarian tissue, presenting a starry sky pattern. The tumor cells expressed CD20, CD79-a, PAX5, CD10, BCL6, and MYC in the absence of BCL2, CD3, CD5, CD138, and TdT. A significant Ki-67 proliferation index was revealed at virtually 90%. FISH examination indicated positive MYC (8q24) rearrangement but negative, BCL2 (18q21) and BCL6 (3q37) rearrangement. Cumulative evidence indicated primary ovarian Burkitt lymphoma as the final histopathological diagnosis. The patient was treated with 8 courses of CODOX-M/IVAC combined with HyperCVAD chemotherapy after surgery. Conclusion: By reporting the histological patterns, immunophenotypes, FISH, and successful post-surgical combined chemotherapy of this rare case of primary ovarian Burkitt lymphoma, we expected to provide insights into the future treatment of this rare but lethal disease.