Mannose binding lectin as a marker for coronary artery disease in hypertension

M Dilagamari, V.Amuthavalli
2025 · W7030115436
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This cross-sectional case-control study measured serum mannose binding lectin (MBL) by ELISA in 180 participants: recently diagnosed hypertensive patients (<6 months), hypertensive patients with a recent myocardial infarction (<7 days), and age- and sex-matched healthy controls. The authors found MBL levels were significantly higher in both hypertensive groups than in controls, with the highest levels in those with recent myocardial infarction, and they reported ROC-derived performance estimates (sensitivity 93%, specificity 96%). The major caveat is that the study is cross-sectional and the conclusions are framed as requiring further validation. Relevance to endometriosis: the paper focuses on cardiovascular risk markers in hypertension and does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Background According to The Framingham Heart Study and the Epidemiology of Cardiovascular Diseases hypertension is an independent risk factor for cardiovascular disease (1). Inflammation plays a major role in atherosclerosis. Markers of innate immunity have been shown to predict the development of coronary artery disease. MBL (Mannose binding lectin) being a component of innate immunity can be used as a marker of cardiovascular risk in hypertension. Aim & Objectives: The study was conducted to evaluate the risk of coronary artery disease in recently diagnosed hypertensive patients by estimating serum mannose binding lectin levels Materials & Methods: This cross sectional case control study was conducted among 180 subjects who were divided into three groups as follows Group A : 60 recently diagnosed hypertensive patients ( < 6 months duration ) Group B : 60 hypertensive patients who had myocardial infarction recently (< 7 days) Group C : 60 age & sex matched healthy controls Serum levels of MBL was evaluated in the three groups using ELISA technique. Collected data were analysed statistically. Results & Conclusion: The serum MBL levels were significantly elevated in hypertensive patients (mean = 823.45 ng/mL; Range – 772 to 875 ng/mL) and in hypertensive with myocardial infarction (mean = 1163.39 ng/mL; Range – 945 to 1381 ng/mL) as compared with control population (mean = 607.15 ng/mL; Range – 513 to 701 ng/mL) with p value of 0.001. From the ROC curve, it has been determined that MBL has sensitivity of 93% & specificity of 96%) with a positive predictive value of 96% & negative predictive value of 84.65%. Our findings suggested the determination of MBL status may serve as a potential marker for early identification of patients at risk of cardiovascular complications, pending further validation studies.
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Global Journal of Medicine and Public Health (Apr 2025) Mannose binding lectin as a marker for coronary artery disease in hypertension Abstract Background According to The Framingham Heart Study and the Epidemiology of Cardiovascular Diseases hypertension is an independent risk factor for cardiovascular disease (1). Inflammation plays a major role in atherosclerosis. Markers of innate immunity have been shown to predict the development of coronary artery disease. MBL (Mannose binding lectin) being a component of innate immunity can be used as a marker of cardiovascular risk in hypertension. Aim & Objectives: The study was conducted to evaluate the risk of coronary artery disease in recently diagnosed hypertensive patients by estimating serum mannose binding lectin levels Materials & Methods: This cross sectional case control study was conducted among 180 subjects who were divided into three groups as follows Group A : 60 recently diagnosed hypertensive patients ( < 6 months duration ) Group B : 60 hypertensive patients who had myocardial infarction recently (< 7 days) Group C : 60 age & sex matched healthy controls Serum levels of MBL was evaluated in the three groups using ELISA technique. Collected data were analysed statistically. Results & Conclusion: The serum MBL levels were significantly elevated in hypertensive patients (mean = 823.45 ng/mL; Range – 772 to 875 ng/mL) and in hypertensive with myocardial infarction (mean = 1163.39 ng/mL; Range – 945 to 1381 ng/mL) as compared with control population (mean = 607.15 ng/mL; Range – 513 to 701 ng/mL) with p value of 0.001. From the ROC curve, it has been determined that MBL has sensitivity of 93% & specificity of 96%) with a positive predictive value of 96% & negative predictive value of 84.65%. Our findings suggested the determination of MBL status may serve as a potential marker for early identification of patients at risk of cardiovascular complications, pending further validation studies.

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