Pulmonary sequestration presenting elevated CA19-9 and CA125 with ovarian cysts

Hiroaki Komatsu, Shinjiro Mizuguchi, Nobuhiro Izumi, Hidetoshi Inoue, Hiroko Oka, Shigefumi Suehiro, Noritoshi Nishiyama
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2014 · doi:10.5761/atcs.cr.13-00219 · PMID:24583704
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This case describes a pulmonary sequestration with elevated CA19-9 and CA125 levels that resolved after surgical resection of the sequestration and an ovarian endometrioma.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This case report describes a 41-year-old woman evaluated for elevated tumor markers CA19-9 and CA125, in whom imaging identified an intralobar pulmonary sequestration in the right lower lobe along with bilateral cystic ovarian tumors. The left ovarian cyst was resected and diagnosed as an endometrioma, but CA19-9 and CA125 remained elevated after surgery, leading to a right lung S10 segmentectomy; immunohistochemistry showed CA19-9 positivity in bronchial and alveolar epithelia and mucus within the sequestrated lung. CA19-9 and CA125 then decreased to normal after pulmonary resection, with the report noting the limitation of being a single case and that the persistent marker elevation required sequential interventions to identify the source. Relevance to endometriosis: the paper explicitly involves an ovarian endometrioma as part of the patient’s presentation alongside pulmonary sequestration, linking elevated CA19-9/CA125 to endometriosis-associated cysts in the diagnostic context.

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Abstract

A 41-year-old woman was evaluated because of elevated serum levels of the tumor markers CA19-9 and CA125. Whole-body examination revealed an intralobar pulmonary sequestration in the right lower lobe and bilateral cystic ovarian tumors (right: 20 mm, left: 60 mm in diameter, respectively). The left ovarian cyst was resected and diagnosed as an endometrioma. The right ovarian cyst was preserved because of its small size. However, the tumor marker levels remained elevated postoperatively. S10 segmentectomy of the right lung was subsequently performed. Immunohistochemical examination of the sequestrated lung demonstrated positive staining for CA19-9 in the bronchial and alveolar epithelia and mucus. After the pulmonary resection, the CA19-9 and CA125 levels decreased to their normal ranges.
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Case Reports Pulmonary Sequestration Presenting Elevated CA19-9 and CA125 with Ovarian Cysts 2014 Volume 20 Issue Supplement Pages 686-688 Details Abstract A 41-year-old woman was evaluated because of elevated serum levels of the tumor markers CA19-9 and CA125. Whole-body examination revealed an intralobar pulmonary sequestration in the right lower lobe and bilateral cystic ovarian tumors (right: 20 mm, left: 60 mm in diameter, respectively). The left ovarian cyst was resected and diagnosed as an endometrioma. The right ovarian cyst was preserved because of its small size. However, the tumor marker levels remained elevated postoperatively. S10 segmentectomy of the right lung was subsequently performed. Immunohistochemical examination of the sequestrated lung demonstrated positive staining for CA19-9 in the bronchial and alveolar epithelia and mucus. After the pulmonary resection, the CA19-9 and CA125 levels decreased to their normal ranges. © 2014 The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/ Favorites & Alerts Recently viewed articles

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Condition tags

endometriosisendometrioma

MeSH descriptors

Bronchopulmonary Sequestration Endometriosis Ovarian Cysts Adult Biomarkers, Tumor Biomarkers, Tumor Bronchopulmonary Sequestration Bronchopulmonary Sequestration CA-125 Antigen CA-125 Antigen CA-19-9 Antigen CA-19-9 Antigen Endometriosis Endometriosis Female Humans Immunohistochemistry Ovarian Cysts Ovarian Cysts Tomography, X-Ray Computed

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