Migrasomes, Matrix-bound Nanovesicles, and More: Messengers in the Matrix

Migrasomes, Matrix-bound Nanovesicles, and More: Messengers in the Matrix | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL PROTEOMICS This is a preprint and has not been peer reviewed. Data may be preliminary. 28 March 2025 V1 Latest version Share on Migrasomes, Matrix-bound Nanovesicles, and More: Messengers in the Matrix Authors : Anna Kolesov , Natalie Reitz , Marley Dewey , and Colin Hisey 0000-0001-8732-3600 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174315962.29311717/v1 Published PROTEOMICS Version of record Peer review timeline 582 views 319 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Extracellular vesicles (EVs) and particles (EPs) are diverse micro- and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix-bound or matrix-associated EVs and EPs (MEVPs) has been unclear, largely due to an apparent bias in the field towards EVs found in fluids and a lack of consensus guidelines. Recently, there has been a growing appreciation for several subtypes of MEVPs and their roles in applications ranging from wound healing to metastasis. However, progress in these fields has largely been achieved in silos, with minimal consideration for overlap or complementary function between different MEVPs. In this article, we briefly describe this growing field with a focus on heterogeneity and the lack of consensus, then discuss challenges and opportunities in improving MEVP isolation and characterization. Importantly, proteomic analyses of these unique MEVPs will be crucial in promoting rigor, reproducibility, and understanding in this exciting new field. Supplementary Material File (migrasomes, matrix-bound nanovesicles, and more_ messengers in the matrix.pdf) Download 1.23 MB File (table 1.pdf) Download 141.65 KB Information & Authors Information Version history V1 Version 1 28 March 2025 Peer review timeline Published PROTEOMICS Version of Record 14 Oct 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection PROTEOMICS Keywords extracellular matrix extracellular vesicles matrix vesicles migrasomes proteomics Authors Affiliations Anna Kolesov Northwestern University View all articles by this author Natalie Reitz Northwestern University View all articles by this author Marley Dewey University of California Santa Barbara View all articles by this author Colin Hisey 0000-0001-8732-3600 [email protected] Northwestern University View all articles by this author Metrics & Citations Metrics Article Usage 582 views 319 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Anna Kolesov, Natalie Reitz, Marley Dewey, et al. Migrasomes, Matrix-bound Nanovesicles, and More: Messengers in the Matrix. Authorea . 28 March 2025. DOI: https://doi.org/10.22541/au.174315962.29311717/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); Cited by A light-induced micropatterning technique for extracellular vesicles and particles, Nature Methods, 22 , 12, (2510-2511), (2025). https://doi.org/10.1038/s41592-025-02915-9 Crossref Loading... View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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