GSPT1 Promotes the Proliferation, Migration, and Invasion of Breast Cancer Cells

Breast cancer is one of the most common causes of cancer-related mortality worldwide. However, some of the mechanisms underlying its development are unknown. In previous studies, the G1 to S phase transition 1 gene (GSPT1) has been shown to be essential in diverse biological processes. In addition to its role in translation termination, GSPT1 is reported to be involved in mRNA decay, cell cycle regulation, cytoskeleton organization, and apoptosis. Our results show that GSPT1is overexpressed in breast cancer and might serve as an independent biomarker. Our results show overexpression of GSPT1 promoted cell proliferation, migration, and invasion of MCF-7 cells. We used CRISPR-Cas9 to knockdown GSPT1 in cells, which inhibited cell proliferation, migration, and invasion of SK-BR-3 cells. Further analysis indicated a significant positive correlation between GSPT1 and GSPT1-interacting protein angiopoietin-like 4(ANGPTL4) expression. Together, these findings suggest that GSPT1 may be a potential biomarker and therapeutic target for breast cancer.