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by claude@2026-06, 2026-06-11
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This study investigated the roles of hepatocyte growth factor, macrophages, and ovarian steroids in the immunopathogenesis of pelvic endometriosis, focusing on inflammation triggered by LPS and mediated by TLR4.
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by claude@2026-06, 2026-06-11
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This paper reviews and synthesizes a series of studies examining pelvic inflammation in endometriosis, focusing on innate immune activation by bacterial endotoxin (lipopolysaccharide) through toll-like receptor 4 (TLR4). It reports that macrophages are central to inducing pelvic inflammatory reactions and that peritoneal macrophages retain receptors for estrogen and progesterone, enabling ovarian steroids to participate in an inflammatory response and contribute to endometriosis growth either alone or with hepatocyte growth factor (HGF). The paper also describes HGF as a pleiotropic factor with multifunctional roles and presents a step-wise account of how HGF, macrophages, and ovarian steroid hormones are orchestrated in immunopathogenesis. The caveat stated is that despite these insights, an in-depth understanding of endometriosis pathophysiology remains elusive. This paper is centrally about endometriosis — it specifically focuses on the immunopathogenesis involving HGF, macrophages, ovarian steroids, and TLR4-mediated endotoxin-triggered pelvic inflammation.
Abstract
Endometriosis, a chronic disease characterized by endometrial tissue located outside of the uterine cavity and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology of endometriosis is still elusive. It is generally believed that besides ovarian steroid hormones, the growth of endometriosis can be regulated by innate immune system in pelvic microenvironment by their interaction with endometrial cells and immune cells. We conducted a series of studies in perspectives of pelvic inflammation that is triggered primarily by bacterial endotoxin (lipopolysacccharide, LPS) and is mediated by toll-like receptor 4 (TLR4) and showed their involvement in the development of pelvic endometriosis. As a cellular component of innate immune system, macrophages were found to play a central role in inducing pelvic inflammatory reaction. We further reported here that peritoneal macrophages retain receptors encoding for estrogen and progesterone and ovarian steroids also participate in producing an inflammatory response in pelvic cavity and involved in the growth of endometriosis either alone or in combination with hepatocyte growth factor (HGF). As a pleiotropic growth factor, HGF retains multifunctional role in endometriosis. We describe here the individual and step-wise role of HGF, macrophages and ovarian steroid hormones and their orchestrated involvement in the immunopathogenesis of pelvic endometriosis.
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アイテム
Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids
http://hdl.handle.net/10069/22528
http://hdl.handle.net/10069/225280d9580b7-42ce-4c4a-a033-d53b3c752434
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
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AJRI60_383.pdf (2.5 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2009-12-03 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | pelvic endometriosis | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | hepatocyte growth factor | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | macrophages | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | toll-like receptor 4 | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | ovarian steroids | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | inflammation | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
Khan, Khaleque Newaz
× Khan, Khaleque Newaz
× Kitajima, Michio
× Hiraki, Koichi
× Fujishita, Akira
× Sekine, Ichiro
× Ishimaru, Tadayuki
× Masuzaki, Hideaki
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Endometriosis, a chronic disease characterized by endometrial tissue located outside of the uterine cavity and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology of endometriosis is still elusive. It is generally believed that besides ovarian steroid hormones, the growth of endometriosis can be regulated by innate immune system in pelvic microenvironment by their interaction with endometrial cells and immune cells. We conducted a series of studies in perspectives of pelvic inflammation that is triggered primarily by bacterial endotoxin (lipopolysacccharide, LPS) and is mediated by toll-like receptor 4 (TLR4) and showed their involvement in the development of pelvic endometriosis. As a cellular component of innate immune system, macrophages were found to play a central role in inducing pelvic inflammatory reaction. We further reported here that peritoneal macrophages retain receptors encoding for estrogen and progesterone and ovarian steroids also participate in producing an inflammatory response in pelvic cavity and involved in the growth of endometriosis either alone or in combination with hepatocyte growth factor (HGF). As a pleiotropic growth factor, HGF retains multifunctional role in endometriosis. We describe here the individual and step-wise role of HGF, macrophages and ovarian steroid hormones and their orchestrated involvement in the immunopathogenesis of pelvic endometriosis. | |||||||||||||||||||
| 書誌情報 |
American Journal of Reproductive Immunology 巻 60, 号 5, p. 383-404, 発行日 2008-11 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | Blackwell Publishing | |||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 10467408 | |||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA1209144X | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | 10.1111/j.1600-0897.2008.00643.x | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 権利情報 | c 2008 Blackwell Munksgaard | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||
| 引用 | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | American Journal of Reproductive Immunology, 60(5), pp.383-404; 2008 |
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