Identification of differentially expressed pyroptosis-related genes in LUAD

Background Lung cancer has the highest mortality rate among malignant tumors in the world, and adenocarcinoma, the most important pathological type of lung cancer, accounts for 80%-85% of all lung cancers, causing a significant burden of disease. Pyroptosis is a newly recognized form of programmed cell death (PCD). Methods 288 normal tissue data from The Genotype-Tissue Expression (GTEx) database and 501 tumor tissue data from The Cancer Genome Atlas (TCGA) database were selected. Differentially expressed genes were identified between normal and LUAD patients. Results and Conclusions With a consensus cluster analysis, 501 LUAD patients were divided into two clusters, and there was a significant difference in survival time between the two clusters. Ten differentially expressed genes were identified, with four up-regulated and six down-regulated. Pyroptosis is closely related to LUAD.