Genital endometriosis: pathogenesis, diagnosis, and association with malignancies

In: РМЖ. Мать и дитя, Vol 4, Iss 4 (2021) · 2021 · W4312109397
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This paper reviews the pathogenesis, diagnosis via eutopic endometrium examination, and the association of endometriosis with ovarian cancer, noting its similarities to malignancy and potential precursor role.

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The paper reviews genital endometriosis as a hormone-dependent genetic disease linked to impaired immune homeostasis, highlighting that eutopic endometrium in affected women differs from that in healthy controls. It states that morphological examination of eutopic endometrial samples can diagnose endometriosis at an early stage, and it discusses mechanistic similarities between endometriosis and malignancies, including resistance to apoptosis and stimulation of angiogenesis. It also summarizes that recent findings suggest endometriosis can be a precursor of clear cell and endometrioid ovarian cancer, while noting that further work is needed to identify novel diagnostic markers. This paper is centrally about endometriosis — specifically its pathogenesis and diagnosis and its association with ovarian malignancies.

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Abstract

I.Yu. Il’ina1, D.V. Burdin2, M.R. Narimanova1, D.M. Ibragimova1 1Pirogov Russian National Research Medical University, Moscow, Russian Federation 2N.I. Pirogov City Clinical Hospital No. 1, Moscow, Russian Federation Endometriosis is a hormone-dependent genetic disease that develops in impaired immune homeostasis. However, its pathogenesis remains an enigma. It is known that eutopic endometrium in women with endometriosis is different from that in healthy women. Morphologic examination of eutopic endometrium sample allows diagnosing endometriosis at an early stage. To date, the association between endometriosis and the risk of malignancies is in strong focus. Endometriosis is a benign disorder but shares similarities with malignancies, e.g., apoptosis resistance and stimulation of angiogenesis. Recent findings suggest that endometriosis is a precursor of clear cell and endometrioid ovarian cancer. Further studies are needed to identify novel markers of endometriosis for its timely diagnosis. Timely and adequate therapy reduces the prevalence of ovarian tumors. Further development of molecular studies on endometriosis and ovarian cancer predictors will uncover pathogenic mechanisms and find  potential preventive and treatment modalities. Keywords: endometriosis, ovarian cancer, eutopic endometrium, ectopic endometrium, apoptosis, angiogenesis. For citation: Il’ina I.Yu., Burdin D.V., Narimanova M.R., Ibragimova D.M. Genital endometriosis: pathogenesis, diagnosis, and association with malignancies. Russian Journal of Woman and Child Health. 2021;4(4):339–345 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4-339-345.
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РМЖ. Мать и дитя (Dec 2021) Genital endometriosis: pathogenesis, diagnosis, and association with malignancies Abstract I.Yu. Il’ina1, D.V. Burdin2, M.R. Narimanova1, D.M. Ibragimova1 1Pirogov Russian National Research Medical University, Moscow, Russian Federation 2N.I. Pirogov City Clinical Hospital No. 1, Moscow, Russian Federation Endometriosis is a hormone-dependent genetic disease that develops in impaired immune homeostasis. However, its pathogenesis remains an enigma. It is known that eutopic endometrium in women with endometriosis is different from that in healthy women. Morphologic examination of eutopic endometrium sample allows diagnosing endometriosis at an early stage. To date, the association between endometriosis and the risk of malignancies is in strong focus. Endometriosis is a benign disorder but shares similarities with malignancies, e.g., apoptosis resistance and stimulation of angiogenesis. Recent findings suggest that endometriosis is a precursor of clear cell and endometrioid ovarian cancer. Further studies are needed to identify novel markers of endometriosis for its timely diagnosis. Timely and adequate therapy reduces the prevalence of ovarian tumors. Further development of molecular studies on endometriosis and ovarian cancer predictors will uncover pathogenic mechanisms and find potential preventive and treatment modalities. Keywords: endometriosis, ovarian cancer, eutopic endometrium, ectopic endometrium, apoptosis, angiogenesis. For citation: Il’ina I.Yu., Burdin D.V., Narimanova M.R., Ibragimova D.M. Genital endometriosis: pathogenesis, diagnosis, and association with malignancies. Russian Journal of Woman and Child Health. 2021;4(4):339–345 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4-339-345.

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