Clinical Observation of LNG-IUS in Treatment of Adenomyosis

Objective:To investigate clinical efficacy and safety of Mirenain(levonorgestrel-releasing intrauterine system,LNG-IUS)remedied adenomyosis.Method:A tatle of 48 female adenomyosis patients who were suffering from severe dysmenorrhea and menorrhagia volunteered for inserting Mirena in our hospital.The degree of dysmenorrhea,menstruation,hemoglobin,level of CA125 in serum and both of the change in uterine volume and endometrial were compared between befor insertion and after it for 3,6,12 months.Result:All patients had remitted dysmenorrheal,reduced menstruation obviously and their endometrial had thin,during the fisrt 3 months.It was signifcant by comparing wirh before insertion.During the firsr 3 months,the second and the fourth ,10 anemia patients’hemoglobin grew up ,comparing with befor insertion significantly(P 0.05).CA125 level in serum of all patients decreased after 12 months,comparing with before inserting significantly( P 0.05).Uterine volume slightly reduced which was not significant( P 0.05)compared with before insertion.There were 9 patients had side-effects:4 abnormal hemorrhage,3 amenorrhea,1 swollen breasts , 1 Mirena expulsion.Conclusion:Mirena was proved to be not only safe,effciacious but also valuable for clinical application in adenomyosis treament.