Network analyses of circular RNAs expression profiles and their hub genes in pancreatic ductal adenocarcinoma

Network analyses of circular RNAs expression profiles and their hub genes in pancreatic ductal adenocarcinoma | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Network analyses of circular RNAs expression profiles and their hub genes in pancreatic ductal adenocarcinoma Yanyan Tang, Ping Zhang This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.15313/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most common malignant tumor in digestive system. CircRNAs involve in lots of biological processes through interacting with miRNAs and their targeted mRNA. We obtained the circRNA gene expression profiles from Gene Expression Omnibus (GEO) and identified differentially expressed genes (DEGs) between PDAC samples and paracancerous tissues. Bioinformatics analyses, including GO analysis, KEGG pathway analysis and PPI network analysis, were conducted for further investigation. We also constructed circRNA‑microRNA-mRNA co-expression network. A total 291 differentially expressed circRNAs were screened out. The GO enrichment analysis revealed that up-regulated DEGs were mainly involved metabolic process, biological regulation, and gene expression, and down-regulated DEGs were involved in cell communication, single-organism process, and signal transduction. The KEGG pathway analysis, the upregulated circRNAs were enriched cGMP-PKG signaling pathway, and HTLV-I infection, while the downregulated circRNAs were enriched in protein processing in endoplasmic reticulum, insulin signaling pathway, regulation of actin cytoskeleton, etc. Four genes were identified from PPI network as both hub genes and module genes, and their circRNA‑miRNA-mRNA regulatory network also be constructed. Our study indicated possible involvement of dysregulated circRNAs in the development of PDAC and promoted our understanding of the underlying molecular mechanisms. Epigenetics & Genomics circular RNA pancreatic carcinoma expression profile regulatory network Figures Figure 1 Figure 2 Figure 3 Figure 4 Introduction Pancreatic ductal adenocarcinoma (PDAC), which is the most common form of pancreatic carcinoma, remains the fourth highest mortality rate malignant neoplasms in the United States. More specifically, its estimated deaths will be 43,090 in 2017 [ 1 ]. The prognosis of PDAC is poor. It is a highly metastatic tumor and therapy resistant. Its survival rate is approximately 25% of 1-year and 5% of 5-year [ 2 ]. Beside the dietary habit and environmental factors, PDAC is also related with genetic basis. The family history of pancreatic carcinoma is predisposing to increased risk in direct relatives [ 3 ]. The early diagnostic is very hard due to lack of characteristic symptoms and cancer late stage during first oncological visit. It is usually not adequate to treat this disease by surgical resection [ 4 ]. There are still need potent specific biomarkers for early diagnosis. System analyses of PDAC may provide better understanding to this disease and contribute to developing more effective approaches. Circular RNAs (circRNAs) was first declared in 1976 [ 5 ]. However, circRNAs were almost completely neglected since then, because it is difficult to be detected using traditional molecular techniques, and hard to be mapped into genomes [ 6 ]. With the development of sequencing technologies and bioinformatics methodologies, circRNAs have become the focal research in the biological field [ 7 ]. CircRNAs are unusually regarded as stable molecules. Their 3’ and 5’ ends are linked together covalently [ 8 ], and thus lack of a free end, which prevents them depredated as the conventional RNA. The special features of circRNA, such as stability, abundance, and tissue-specific expression pattern, make them very attractive for clinical research, as they can be employ as new ways in diagnosis [ 4 ]. CircRNAs can repress the function of microRNA (miRNA) by binding to miRNA as sponges [ 9 ]. They involve in lots of biological processes by interacting with miRNAs and their target mRNA. CircRNAs have been reported in several types of diseases, including Alzheimer’s disease [ 10 ], colorectal cancer [ 11 ], atherosclerotic vascular disease [ 12 ], and osteoarthritis [ 13 ]. To explore the underlying molecular regulation mechanism of circRNAs in PDAC, circRNAs microarray was used to detect the differential expressed circRNAs between PDAC tissues and paracancerous tissues. Our results suggested that the dysregulated expression of circRNAs may play a role in transformation of PDAC. Materials and Methods 2.1. Microarray data The circRNA expression profiles were obtained from Gene Expression Omnibus (GEO ), where the accession number is GSE79634. It contains 40 samples, including twenty fresh-frozen PDAC samples and twenty paracancerous tissues. The circRNA expression levels of these samples were measured using Agilent–069978 Arraystar Human circRNA microarray V1. Total RNA was extracted from collected samples. After labeling and hybridizing, the acquired array images were analyzed using Agilent Feature Extraction software (version 11.0.1.1). Quantile normalization and subsequent data processing were performed using the R software package. 2.2. Identification of differentially expressed genes Differentially expressed genes (DEGs), which were significantly differentially expressed among the PDAC samples and the paracancerous tissues, were identified by using the LIMMA package in R language. LIMMA provides several p-value adjustment options to correct for the occurrence of false positive results. It was also known as multiple-testing corrections, where the Benjamini & Hochberg false discovery rate method was selected by default in the package. We defined adjusted p-values ≤0.05 and absolute value of fold change ≥ 2 as the cutoff to determine the statistically significance of gene expression difference. 2.3. GO enrichment analysis Gene Ontology (GO ) is a common useful framework for the model of biology. The GO project provides a computational representation of our evolving knowledge on how genes encode biological functions. It has defined formal ontologies that represent over 40,000 biological concepts at the molecular, cellular and system levels, to describe gene function and relationships between them. 2.4. KEGG pathway analysis Kyoto encyclopedia of genes and genomes (KEGG ) database resource is an encyclopedia of genes and genomes for understanding high-level functions and utilities of the biological system from molecular-level information, especially large-scale molecular datasets generated by genome sequencing and other high-throughput experimental technologies. It assigns functional meanings to genes and genomes both at the molecular and higher levels. Molecular level functions are maintained in the KO (KEGG Orthology) database, while higher-level functions are defined in the forms of KEGG modules, KEGG pathway maps and BRITE hierarchies [ 14 ]. 2.5. PPI network analysis It is widely accepted that the interactions and partnerships between proteins are play important roles in biological regulation. The protein–protein interaction networks, which are constructed from either known or predicted interactions, provide us with topological summary of our research subjects. A larger number of online resources contain this protein–protein interaction information. These interactions were generated either from experimental techniques [ 15 , 16 ] or from computational prediction [ 17–19 ]. A group of databases integrate both known and predicted interactions, to provide much high comprehensiveness and coverage. Typical databases include GeneMANIA [ 20 ], FunCoup [ 17 ], I2D [ 21 ], and STRING [ 22 ]. Highly complex biological functions are often undertaken by tightly interacted groups of proteins. PPI network was constructed in Cytoscape, and the significant modules were identified using the plug-in Molecular Complex Detection (MCODE). 2.6. Target prediction and co-expression network To further investigate the functional roles of circRNA, the miRNAs regulated by these circRNA and corresponding target genes were extracted from CIRCNET database. The circRNA-microRNA-mRNA co-expression networks were constructed based on this information by using Cytoscape. Results 3.1. Differentially expressed genes Differentially expressed genes (DEG) were identified from microarray data, using the criteria of adj. P. Value1. A total of 291 circRNA genes were screened out between the PDAC tissues and paracancerous tissues after preprocessing of microarray data, including 128 up-regulated circRNAs and 163 down-regulated circRNAs. The expression levels of these dysregulated expression circRNAs were distinguishable and variations, which were demonstrated from the volcano plot (Figure 1A) and heatmap (Figure 1B). The top 10 up-regulated and down-regulated circRNAs were listed in Table 1. For example, hsa_circ_0006220 (TADA2A), hsa_circ_0000977 (NOL10) and hsa_circ_0001666 (FAM120B) were up-regulated with top magnitudes. Meanwhile, hsa_circ_0000518 (RPPH1) hsa_circ_0072088 (ZFR) and hsa_circ_0005273 (PTK2) were down-regulated with top magnitudes. 3.2. Enrichment analysis of DEGs The Gene Ontology (GO) enrichment analyses were performed on these 128 upregulated and 163 downregulated circRNAs respectively. Table 2 was the summary of GO enrichment analysis results, which listed the number of enriched GO terms at different significant level ( P <0.10 or P <0.05). Table 3 and Table 4 were top 10 GO terms ( P <0.05), respectively. GO enrichment analysis revealed that numerous genes were involved in the biological processes. For example, according to the gene ontology enrichment analysis results, the up-regulated circRNAs were enriched ( P <0.05) in 80 biological processes, including biological regulation, metabolic process, and gene expression, etc. Meanwhile, the downregulated circRNAs were enriched ( P <0.05) in 151 biological processes, including single-organism process, cell communication, and signal transduction, etc. These processes were associated with PDAC. 3.3. KEGG pathway analysis KEGG pathway analysis results were listed in Table 5. The cutoff used for this analysis was P <0.05. According to these results, the upregulated circRNAs were enriched in 2 pathways including cGMP-PKG signaling pathway, and HTLV-I infection, while the downregulated circRNAs were enriched in 10 pathways, including Protein processing in endoplasmic reticulum, insulin signaling pathway, regulation of actin cytoskeleton, etc. 3.4. PPI network analysis and hub genes screening The PPI (protein-protein interaction) network of the dysregulation genes were constructed by Cytoscape software, where the interaction information was extracted from the STRING database. As shown in Figure 2A, the red triangle nodes represent upregulated genes and green circular nodes represent downregulated genes, respectively. The PPI network was further analyzed by screening its hub genes and identifying significant modules. In the PPI networks, the nodes with high degree are defined as hub genes. The top 10 hub genes were ACACA, ACACB, GSK3B, LRRK2, PRKG1, UBQLN1, FOXO1, AXIN1, MTHFD1L and PTK2. The most significant hub proteins in the PPI network were ACACA (degree = 19) and ACACB (degree = 18). We also analyzed the PPI network using MCODE, which is a Cytoscape plug-in that finds clusters (or modules, highly interconnected regions) in a network. In PPI network, clusters are often protein complexes and parts of pathways. There were 3 modules identified in this PPI network (Figure 2A). The most significant modules contained ACACB, ACACA, AACS, ALDH7A1 and MTHFD1L. The other two modules contained GNAI2, MAP2K2, LRRK2, CAP1, EPS15L1, and EPS15. 3.5. CircRNA-microRNA-mRNA co-expression network As shown in Table 6, there were four genes identified as both hub genes and module genes in the PPI network analysis, including ACACA, MTHFD1L and LRRK2. The circRNA-microRNA-mRNA co-expression networks were constructed based on these genes. The miRNAs regulated by these circRNA and corresponding target genes were extracted from CIRCNET database. Due to limited space, no more than five top significant regulated miRNAs of each circRNA were reserved for the construction of co-expression network, and so do their target genes. Figure 3 (A-C) are the circRNA-microRNA-mRNA networks of ACACA, LRRK2 and MTHFD1L, respectively. The purple nodes at the center of each network were the circRNA genes to be analyzed. The red nodes were the corresponding circRNA, the green nodes were miRNAs, and the light blue nodes were regulated gene. The purple edges linked circRNAs and their transcripts. The red edges linked transcripts and their regulated miRNAs. The gray edges linked miRNAs and their target gene. According to Figure 4A, different transcripts of a specific circRNA could regulated the same miRNA, and different miRNA could regulate the same target gene. The more the transcripts, the more likely the co-regulation exists, and the more complex the network. For example, in the co-expression network of ACACA, both circ-ACACA.171 and circ-ACACA.75 regulated three common miRNAs, i.e. miR–137, miR–338–3p, and miR–376a–5p. Meanwhile, both miR–338–3p and miR–1288–3p regulated SLFN12L. For more complex regulatory networks with multiple circRNA, different circRNAs could co-regulate the same miRNA. For example, there are two circRNA in Figure 4 miR–508–5p is regulated by two transcripts of ACACB (circ-ACACB.74 and circ-ACACB.25) and one transcript of MTHFD1L (circ-MTHFD1L.11). In the circRNA-miRNA-mRNA regulatory network, there also existed closed loops. That is, circRNA regulated miRNA through its specific transcript, and miRNA may also regulate circRNA in turn, thus forming a closed loop structure. For example, in Figure 4, ACACB regulated miR–6849–3p through circ-ACACA.15, and miR–6849–3p in turn inhibits the expression of ACACB, thereby forming a closed loop. Discussion Pancreatic ductal adenocarcinoma is an aggressive malignant neoplasm with extremely high mortality rate, mainly because of difficult early diagnostic and poor prognosis. Current available therapeutic methods are almost ineffective [ 23 ]. The potential improvement of the diagnosis may exist in the strictly molecular biomarkers [ 24 ]. CircRNA is a new special kind of RNAs. Recent evidences revealed that circRNAs can function as miRNA sponges and affect disease by regulating gene expression. In the present study, we employed bioinformatics technology to investigate the underlying molecular mechanism of PDAC. Differentially expressed profiles of circRNAs in PDAC tissues were observed and validated compared with the paracancerous tissues, indicating possible involvement of these dysregulated circRNAs in the development of PDAC. By using microarray data, we observed a total of 291 circRNAs differentially expressed between PDAC tissues and paracancerous tissues, including 128 up-regulated circRNAs and 163 down-regulated circRNAs. Among these differentially expressed genes, hsa_circ_0006220, hsa_circ_0000977 and hsa_circ_0001666 were upregulated with top magnitudes, while hsa_circ_0000518, hsa_circ_0072088 and hsa_circ_0005273 were downregulated with top magnitudes. The differential expression levels of these genes may be related to the involvement in the transcription level regulation on PDAC. Cumulative evidence has demonstrated that co-expression genes usually participate in similar biological process. In order to better understand the interactions of these differentially expressed genes, we further applied GO and KEGG pathway analysis on them. The GO enrichment analysis results revealed that up-regulated DEGs were mainly involved metabolic process, biological regulation, and gene expression, and down-regulated DEGs were involved in cell communication, single-organism process, and signal transduction. As is well-known, the symptoms of the patients with cancer, such as cachexia, wasting syndrome, is related to metabolic disorders. Recent studies showed that, in the case of caloric deficiency, tumor induced changes in host metabolism, leading to tumor immunosuppression. For example, in pre-cachexia mice with PDA, IL6 reduced liver ketogenic ability by inhibiting PPAR alpha. When these mice challenged with caloric deficiency, it would lead to hypoketonemia, and induce the elevation of glucocorticoid levels. A variety of tumor immune pathways was inhibited by above stress response, and thus promoted the progression of pancreatic cancer [ 25 ]. Furthermore, poor survival rates in patients with PDAC were attributed to abnormally high levels of metastasis. Study showed that the metabolic reprogramming of tumor infiltrating macrophages played a key role in PDAC metastasis [ 26 ]. In addition, autophagy is required to maintain energy homeostasis by degrading unnecessary cellular components and molecules. In recent years, it has been found that autophagy can regulate the metabolism of tumor. Autophagy plays a crucial role in the maintenance of tumor survival. PDAC cells require autophagy and glutamine transporters to maintain intracellular glutamine levels [ 27 ]. Therefore, we hypothesized that the high expressed circRNAs may promote the metastasis of pancreatic cancer through various metabolic process, such as, stress response, metabolic reprogramming and glutamine metabolism. PDAC is a highly metastatic tumor with poor prognosis, and intercellular communication is the key to metastasis [ 28 ]. Research showed that PDAC-derived exosomes induced liver pre-metastasis niche formation in nude mice, and increased the load of liver metastasis. Kupffer cells uptaked PDAC-derived exosomes, resulting in transforming growth factor β (TGF-β) and upregulation of fibronectin production by hepatic stellate cells. This fibrotic microenvironment increases the number of bone marrow-derived macrophages. The authors found that macrophage migration inhibitory factor (MIF) was highly expressed in PDAC derived exosomes, and MIF promote metastasis, and liver metastasis before niche formation. It can be seen that the MIF of the exocrine body is initially transferred to the liver, which may be a prognostic indicator of PDAC liver metastasis [ 28 ]. The low expression of circRNAs might be a tumor suppressor gene, which inhibit tumor pre-metastasis niche formation and tumor metastasis. Therefore, we can take this as the target for prevention and control, promote the expression of these circRNAs, block the cell mediated intercellular communication, and prevent the metastasis of pancreatic cancer. According to the KEGG pathway analysis, the upregulated circRNAs were enriched cGMP-PKG signaling pathway, and HTLV-I infection, while the downregulated circRNAs were enriched in 10 pathways, including protein processing in endoplasmic reticulum, Insulin signaling pathway, regulation of actin cytoskeleton, etc. Recent evidence indicated that both cGMP-PKG and Insulin were play important roles in PDAC. Our KEGG analysis results show that a large number of down-regulated circRNA of pancreatic cancer were enriched in the pathway of Protein processing in endoplasmic reticulum. Similarly, Peng et al. used the KEGG analysis and found that many endoplasmic reticulum (ER)-associated proteins were altered in solid pseudopapillary tumor of the pancreas (SPTP), suggesting that endoplasmic reticulum stress may play an important role in SPTP tumorigenesis. They also verified 7 proteins in the pathway by immunohistochemistry, including ERO1LB, TRIM1, BIP, SEC61B, P4HB, GRP94 and, PDIA4. Six of these proteins (except SEC61B) were consistent with the LC-MS/MS results [ 29 ]. Our KEGG analysis results also showed that the down regulated circRNAs of pancreatic cancer were enriched in insulin signaling pathway. It has been reported that hyperinsulinemia was a clear risk factor for pancreatic cancer, and an increase in hyperinsulinemia associated with obesity and type 2 diabetes heralded an increased incidence of cancer. The role of insulin in pancreatic cancer progression was worth to be further studied [ 30 ]. They suggested that the overexpression of insulin signaling contributes to the survival and proliferation of human immortalized pancreatic ductal cells and metastatic pancreatic cancer cells, but does not affect normal pancreatic ductal cells. They also suggested that cell survival associated insulin pathway may be involved in the progression of pancreatic cancer [ 30 ]. There were also literatures about insulin signaling pathway and chemotherapeutic resistance of pancreatic cancer. Ireland et al. found that tumor associated macrophages (TAM) and myofibroblasts activated insulin /IGF receptor by secreting IGF1–1 and 2, and directly promote chemoresistance of pancreatic cancer cells resistance. Analysis of biopsies from patients with pancreatic cancer showed that 72% of the patients’ tumor cells had expressed activated insulin / IGF receptor. Therefore, inhibition of IGF might contribute to the treatment of PDAC patients with chemotherapy resistance, and activation of insulin /IGF1R might be used as a biomarker for the identification of chemotherapy resistance [ 31 ]. In addition, adaptor protein CrkII played an important role in the proliferation and invasion of some malignant tumors. However, the specific mechanism of insulin like growth factor 1 (IGF–1) -CrkII signal induced proliferation of PDAC was not clear. Studies have further demonstrated that the CrkII in insulin signaling pathway mediated IGF–1 signaling and affected PDAC through Erk1/2 and Akt pathway, suggesting that CrkII gene and protein could be used as an effective therapeutic targets for PDAC [ 32 ]. We further applied PPI network analysis to these aberrant expression genes. Ten hub genes with the top degree were obtained from the PPI network. We also identified three top significant modules by clustering. A total of eleven module genes were contain in these three module. Four genes were existed both as hub genes and module genes, including ACACA, MTHFD1L and LRRK2. We predicted the target genes of these four circRNA genes, and constructed circRNA-miRNA-Gene regulatory networks for them. On one hand, These genes regulated the expression of miRNAs by transcribing a variety of circRNAs, and further regulated the target genes through miRNAs. According to these regulatory networks, the more circRNAs, the more complex the regulation of miRNA and target genes. There existed multiple miRNAs regulated by the same circRNA. There also existed the same miRNA regulated by several circRNAs of a specific gene. In addition, circRNAs of different genes might regulate the same miRNA. On the other hand, On the other hand, miRNA also could bind to the target gene, and then regulated circRNAs via negative feedback, thus forming a closed loop. For example, circ-ACACB.74, circ-ACACB.25, and circ-MTHFD1L.101 targeted miR–508–5p simultaneously, and miR–508–5p regulated the expression of ACACB and MTHFD1L through the negative feedback. Therefore, bioinformatic analyses showed that circRNA targeting miR–508–5p might involve in the extremely complex regulation mechanism of PDAC. There exist literatures that miR–508–5p involves in the regulation mechanisms of liver gastric cancer and hepatocellular carcinoma. Shang Y. et al. reported that miR–508–5p play an important role in multidrug resistance (MDR) of gastric cancer by targeting ABCB1 and ZNRD1 [ 33 ]. Further research suggested that the underlying mechanism was related to the miR–27b/CCNG1/P53/miR–508–5p axis, and it was possible to reverse MDR of gastric cancer by restoring the expression levels miR–27b and miR–508–5p [ 34 ]. Yan H. et al. found out that miR–508–5p was aberrant expressed in hepatocellular carcinoma (HCC) [ 35 ]. Wu et al. suggested that miR–508–5p might act as a tumor suppressor of HCC progression by targeting MESDC1 [ 36 ]. Similar to gastric cancer and hepatocellular carcinoma, pancreatic adenocarcinoma is also a disease belong to the digestive system. We have reason to believe that miR–508–5 p may also be in pancreatic adenocarcinoma plays an important role. It is worth to study the problem of whether miR–508–5p participates in PDAC. Declarations Data Availability The microarray data used to support the finding of this study have been deposited in the GEO database (dataset ID: GSE79634), which have been cited. Consent for publication The authors confirm that written consents have been obtained from the patients, to publish this manuscript. Competing interests The authors declare that there are no competing interests in this work. Authors’ contributions Yanyan Tang wrote the manuscript and performed the analysis work. Ping Zhang designed this study and revised the manuscript. 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Notes Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/ ) Gene Ontology Consortium, http://www.geneontology.org/ Kyoto encyclopedia of genes and genomes (KEGG) http://www.genome.jp/kegg/ Tables Table 1. Top 10 upregulated and downregulated circRNAs in the PDAC ID adj. P. Val t B logFC Alias Gene Symbol ASCRP002386 1.46E-09 8.96494 15.32025 6.301989 hsa_circ_0006220 TADA2A ASCRP002932 2.24E-08 7.80154 11.75923 6.156615 hsa_circ_0000977 NOL10 ASCRP004540 3.23E-09 8.60686 14.24016 5.730049 hsa_circ_0001666 FAM120B ASCRP002384 3.05E-09 8.6488 14.36742 5.702157 hsa_circ_0043278 TADA2A ASCRP004499 1.60E-06 6.19504 6.66086 3.455038 hsa_circ_0078297 MTHFD1L ASCRP000816 5.33E-07 6.57821 7.8869 3.135898 hsa_circ_0003600 SOX13 ASCRP000706 1.20E-05 5.45481 4.2992 3.004105 hsa_circ_0013912 POLR3C ASCRP001007 4.85E-05 4.95945 2.74095 2.978418 hsa_circ_0018909 VDAC2 ASCRP002451 1.50E-06 6.21761 6.73311 2.73586 hsa_circ_0044436 KAT7 ASCRP001589 1.33E-06 6.2597 6.86782 2.427013 hsa_circ_0029634 ZMYM2 ASCRP000018 1.63E-09 -8.92144 15.18985 -3.32345 hsa_circ_0000518 RPPH1 ASCRP004099 4.61E-08 -7.50572 10.83219 -2.93726 hsa_circ_0072088 ZFR ASCRP004952 2.63E-07 -6.84074 8.72501 -2.89755 hsa_circ_0005273 PTK2 ASCRP000343 7.68E-09 -8.24112 13.12182 -2.65125 hsa_circ_0000520 RPPH1 ASCRP000385 6.05E-09 -8.33767 13.41847 -2.47966 hsa_circ_0000511 RPPH1 ASCRP000315 9.34E-09 -8.15269 12.84926 -2.45408 hsa_circ_0000517 RPPH1 ASCRP004682 3.89E-07 -6.69486 8.25959 -2.42589 hsa_circ_0081188 SLC25A13 ASCRP003040 1.27E-07 -7.14191 9.68275 -2.40068 hsa_circ_0006110 USP34 ASCRP002376 7.35E-07 -6.46544 7.52625 -2.3365 hsa_circ_0003930 GGNBP2 ASCRP003437 1.53E-05 -5.37134 4.03481 -2.25906 hsa_circ_0061749 BRWD1 Table 2. Summary of GO enrichment analysis Differentially expressed circRNAs The number of enriched GO terms biological process cellular component molecular function p<0.1 p<0.05 p<0.1 p<0.05 p<0.1 p<0.05 up-regulated 135 80 28 17 40 21 down-regulated 233 151 44 27 61 49 Table 3. Top 10 GO enrichment terms of upregulated circRNAs Ontology Accession Name Gene count P value biological process GO:0065007 biological regulation 73 0.0465 GO:0008152 metabolic process 72 0.0196 GO:0071704 organic substance metabolic process 71 0.0118 GO:0044237 cellular metabolic process 68 0.0160 GO:0044238 primary metabolic process 67 0.0290 GO:0043170 macromolecule metabolic process 64 0.0058 GO:0044260 cellular macromolecule metabolic process 61 0.0034 GO:0071840 cellular component organization or biogenesis 49 0.0048 GO:0019222 regulation of metabolic process 48 0.0050 GO:0016043 cellular component organization 48 0.0051 cellular component GO:0005622 intracellular 88 0.0192 GO:0044424 intracellular part 87 0.0123 GO:0043226 organelle 82 0.0299 GO:0043229 intracellular organelle 76 0.0438 GO:0005737 cytoplasm 69 0.0496 GO:0044446 intracellular organelle part 58 0.0119 GO:0044422 organelle part 58 0.0198 GO:0032991 macromolecular complex 36 0.0421 GO:0070013 intracellular organelle lumen 34 0.0225 GO:0043233 organelle lumen 34 0.0283 molecular function GO:0005515 protein binding 65 0.0069 GO:0003824 catalytic activity 44 0.0464 GO:0016740 transferase activity 23 0.0210 GO:0098772 molecular function regulator 17 0.0059 GO:0005524 ATP binding 15 0.0472 GO:0044877 macromolecular complex binding 14 0.0349 GO:0030234 enzyme regulator activity 12 0.0279 GO:0016772 transferase activity, transferring phosphorus-containing groups 12 0.0468 GO:0003712 transcription cofactor activity 11 0.0013 GO:0000989 transcription factor activity, transcription factor binding 11 0.0026 Table 4. Top 10 GO enrichment terms of downregulated circRNAs Ontology Accession Name Gene count P value biological process GO:0044699 single-organism process 103 0.0401 GO:0044763 single-organism cellular process 98 0.0139 GO:0051716 cellular response to stimulus 60 0.0460 GO:0007154 cell communication 57 0.0158 GO:0023052 signaling 56 0.0233 GO:0071840 cellular component organization or biogenesis 56 0.0327 GO:0044700 single organism signaling 55 0.0303 GO:0016043 cellular component organization 55 0.0308 GO:0007165 signal transduction 52 0.0290 GO:0044767 single-organism developmental process 50 0.0346 cellular component GO:0044464 cell part 121 0.0003 GO:0005623 cell 121 0.0004 GO:0005622 intracellular 116 1.15E-06 GO:0044424 intracellular part 115 5.14E-07 GO:0043226 organelle 107 8.95E-05 GO:0005737 cytoplasm 104 2.06E-09 GO:0043229 intracellular organelle 102 4.72E-05 GO:0043227 membrane-bounded organelle 102 7.86E-05 GO:0043231 intracellular membrane-bounded organelle 93 4.52E-04 GO:0044444 cytoplasmic part 88 2.29E-09 molecular function GO:0005488 binding 99 0.0428 GO:0005515 protein binding 74 0.0105 GO:0097159 organic cyclic compound binding 54 0.0110 GO:1901363 heterocyclic compound binding 53 0.0136 GO:0003824 catalytic activity 53 0.0154 GO:0043167 ion binding 42 0.0121 GO:0046872 metal ion binding 41 0.0083 GO:0043169 cation binding 41 0.0102 GO:0036094 small molecule binding 32 6.87E-04 GO:0000166 nucleotide binding 30 9.57E-04 Table 5. KEGG analysis of differential expressed circRNAs Entry Name Gene count P value Up regulated hsa04022 cGMP-PKG signaling pathway 5 0.0085 hsa05166 HTLV-I infection 5 0.0356 Down regulated hsa04141 Protein processing in endoplasmic reticulum 8 0.0004 hsa04910 Insulin signaling pathway 7 0.0009 hsa04810 Regulation of actin cytoskeleton 7 0.0075 hsa04510 Focal adhesion 6 0.0268 hsa00620 Pyruvate metabolism 4 0.0042 hsa00280 Valine, leucine and isoleucine degradation 4 0.0067 hsa05213 Endometrial cancer 4 0.0088 hsa04012 ErbB signaling pathway 4 0.0346 hsa05215 Prostate cancer 4 0.0357 hsa00640 Propanoate metabolism 3 0.0220 Table 6. Hub and Module genes screened from PPI network Type Gene Symbol Intersection Hub Genes ACACA, GSK3B, LRRK2, PRKG1, UBQLN1, FOXO1, AXIN1, MTHFD1L, PTK2, UBA2, MAP3K5. ACACA LRRK2 MTHFD1L Module Genes ACACA, ACACB, AACS, ALDH7A1, MTHFD1L, GNAI2, MAP2K2, LRRK2, CAP1, EPS15L1, EPS15. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5979","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":168237,"identity":"5ebd10c3-337b-4f48-9dd3-5eb3f458d4c3","order_by":1,"name":"Yanyan Tang","email":"","orcid":"","institution":"Central South University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yanyan","middleName":"","lastName":"Tang","suffix":""},{"id":168238,"identity":"1b4d22b1-3b6f-4d50-a4f1-0418cb77aca1","order_by":2,"name":"Ping Zhang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAyUlEQVRIiWNgGAWjYDACCTBpA+HwkKAljXQth0nQIj+7+dnDrzvOy8vPSGB88LaNQd6ckBbGOcfMjWXP3DbccCOB2XBuG4PhzgYCWpglEsykJdtuJxhIJLBJ87YxJBgcIKCFTSL9G1DLuQSgw9h/E6WFRyLHTPJj24EEhhsJbMxEaZGQyCmTZjyTbLjhzMNmyTnnJAw3ENIiPyN9m+TPHXby8u3JBz+8KbORJ2gLCDDzNoAoRhApQYR6kNqfDcQpHAWjYBSMghEKAGcRO5dCZhalAAAAAElFTkSuQmCC","orcid":"","institution":"Central South University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Ping","middleName":"","lastName":"Zhang","suffix":""}],"badges":[],"createdAt":"2019-09-24 16:42:31","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.15313/v1","doiUrl":"https://doi.org/10.21203/rs.2.15313/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":103213,"identity":"241ef065-4524-4670-9124-f5e3499f8910","added_by":"auto","created_at":"2019-09-27 23:08:44","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":234240,"visible":true,"origin":"","legend":"CircRNA microarray expression data between the paracancerous tissues and PDAC tissues. (A) Volcano plot showing microarray data. The red points indicate dysregulated circRNAs with high statistical significance (adj.P. Value \u003c 0.05). (B) Heatmap shows a distinguishable circRNA expression profiling among paracancerous tissues and PDAC tissues.","description":"","filename":"circRNAPDACfigure1.jpg","url":"https://assets-eu.researchsquare.com/files/077f60db-5eeb-4c32-9e93-0483e93c2754/v1/circRNA-PDAC figure 1.jpg"},{"id":103215,"identity":"db7f2dfb-7b8a-4e59-b66f-7959555bcb63","added_by":"auto","created_at":"2019-09-27 23:08:45","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":205716,"visible":true,"origin":"","legend":"PPI network of DEGs. (A) PPI network of dysregulated expressed circRNAs. (B) Top 3 modules identified from PPI network.","description":"","filename":"circRNAPDACfigure2.jpg","url":"https://assets-eu.researchsquare.com/files/077f60db-5eeb-4c32-9e93-0483e93c2754/v1/circRNA-PDAC figure 2.jpg"},{"id":103216,"identity":"d750517b-2b8b-41d1-90b7-52bc457cf5ea","added_by":"auto","created_at":"2019-09-27 23:08:45","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":550305,"visible":true,"origin":"","legend":"CircRNA-miRNA-mRNA regulatory network. (A) Co-expression network of ACACA. (B) Co-expression network of LRRK2. (C) Co-expression network of MTHFD1L.","description":"","filename":"circRNAPDACfigure3.jpg","url":"https://assets-eu.researchsquare.com/files/077f60db-5eeb-4c32-9e93-0483e93c2754/v1/circRNA-PDAC figure 3.jpg"},{"id":103217,"identity":"e8d2b8fc-6ee1-4d01-90cb-1a09340ba0d1","added_by":"auto","created_at":"2019-09-27 23:08:45","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":96191,"visible":true,"origin":"","legend":"A sub regulatory network of ACACB and MTHFD1L. There existed both co-regulation and loop.","description":"","filename":"circRNAPDACfigure4.jpg","url":"https://assets-eu.researchsquare.com/files/077f60db-5eeb-4c32-9e93-0483e93c2754/v1/circRNA-PDAC figure 4.jpg"},{"id":13476650,"identity":"e9d95b14-be31-4e4a-89cf-6a002415a204","added_by":"auto","created_at":"2021-09-16 21:27:37","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":933681,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5979/v1/1f2de9b6-e678-4038-b6b3-1cff59c5ccec.pdf"}],"financialInterests":"","formattedTitle":"Network analyses of circular RNAs expression profiles and their hub genes in pancreatic ductal adenocarcinoma","fulltext":[{"header":"Introduction","content":"\u003cp\u003ePancreatic ductal adenocarcinoma (PDAC), which is the most common form of pancreatic carcinoma, remains the fourth highest mortality rate malignant neoplasms in the United States. More specifically, its estimated deaths will be 43,090 in 2017 [\u003ca href=\"#_ENREF_1\"\u003e1\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eThe prognosis of PDAC is poor. It is a highly metastatic tumor and therapy resistant. Its survival rate is approximately 25% of 1-year and 5% of 5-year [\u003ca href=\"#_ENREF_2\"\u003e2\u003c/a\u003e]. Beside the dietary habit and environmental factors, PDAC is also related with genetic basis. The family history of pancreatic carcinoma is predisposing to increased risk in direct relatives [\u003ca href=\"#_ENREF_3\"\u003e3\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eThe early diagnostic is very hard due to lack of characteristic symptoms and cancer late stage during first oncological visit. It is usually not adequate to treat this disease by surgical resection [\u003ca href=\"#_ENREF_4\"\u003e4\u003c/a\u003e]. There are still need potent specific biomarkers for early diagnosis. System analyses of PDAC may provide better understanding to this disease and contribute to developing more effective approaches.\u003c/p\u003e\n\u003cp\u003eCircular RNAs (circRNAs) was first declared in 1976 [\u003ca href=\"#_ENREF_5\"\u003e5\u003c/a\u003e]. However, circRNAs were almost completely neglected since then, because it is difficult to be detected using traditional molecular techniques, and hard to be mapped into genomes [\u003ca href=\"#_ENREF_6\"\u003e6\u003c/a\u003e]. With the development of sequencing technologies and bioinformatics methodologies, circRNAs have become the focal research in the biological field [\u003ca href=\"#_ENREF_7\"\u003e7\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eCircRNAs are unusually regarded as stable molecules. Their 3’ and 5’ ends are linked together covalently [\u003ca href=\"#_ENREF_8\"\u003e8\u003c/a\u003e], and thus lack of a free end, which prevents them depredated as the conventional RNA. The special features of circRNA, such as stability, abundance, and tissue-specific expression pattern, make them very attractive for clinical research, as they can be employ as new ways in diagnosis [\u003ca href=\"#_ENREF_4\"\u003e4\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eCircRNAs can repress the function of microRNA (miRNA) by binding to miRNA as sponges [\u003ca href=\"#_ENREF_9\"\u003e9\u003c/a\u003e]. They involve in lots of biological processes by interacting with miRNAs and their target mRNA. CircRNAs have been reported in several types of diseases, including Alzheimer’s disease [\u003ca href=\"#_ENREF_10\"\u003e10\u003c/a\u003e], colorectal cancer [\u003ca href=\"#_ENREF_11\"\u003e11\u003c/a\u003e], atherosclerotic vascular disease [\u003ca href=\"#_ENREF_12\"\u003e12\u003c/a\u003e], and osteoarthritis [\u003ca href=\"#_ENREF_13\"\u003e13\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eTo explore the underlying molecular regulation mechanism of circRNAs in PDAC, circRNAs microarray was used to detect the differential expressed circRNAs between PDAC tissues and paracancerous tissues. Our results suggested that the dysregulated expression of circRNAs may play a role in transformation of PDAC.\u003c/p\u003e"},{"header":"Materials and Methods","content":"\u003ch2 data-xsweet-outline-level=\"1\"\u003e2.1. Microarray data\u003c/h2\u003e\n\u003cp\u003eThe circRNA expression profiles were obtained from Gene Expression Omnibus (GEO\u003cnote data-id=\"fn1\"/\u003e), where the accession number is GSE79634. It contains 40 samples, including twenty fresh-frozen PDAC samples and twenty paracancerous tissues. The circRNA expression levels of these samples were measured using Agilent–069978 Arraystar Human circRNA microarray V1. Total RNA was extracted from collected samples. After labeling and hybridizing, the acquired array images were analyzed using Agilent Feature Extraction software (version 11.0.1.1). Quantile normalization and subsequent data processing were performed using the R software package.\u003c/p\u003e\n\u003ch2 data-xsweet-outline-level=\"1\"\u003e2.2. Identification of differentially expressed genes\u003c/h2\u003e\n\u003cp\u003eDifferentially expressed genes (DEGs), which were significantly differentially expressed among the PDAC samples and the paracancerous tissues, were identified by using the LIMMA package in R language. LIMMA provides several p-value adjustment options to correct for the occurrence of false positive results. It was also known as multiple-testing corrections, where the Benjamini \u0026amp; Hochberg false discovery rate method was selected by default in the package. We defined adjusted p-values ≤0.05 and absolute value of fold change ≥ 2 as the cutoff to determine the statistically significance of gene expression difference.\u003c/p\u003e\n\u003ch2 data-xsweet-outline-level=\"1\"\u003e2.3. GO enrichment analysis\u003c/h2\u003e\n\u003cp\u003eGene Ontology (GO\u003cnote data-id=\"fn2\"/\u003e) is a common useful framework for the model of biology. The GO project provides a computational representation of our evolving knowledge on how genes encode biological functions. It has defined formal ontologies that represent over 40,000 biological concepts at the molecular, cellular and system levels, to describe gene function and relationships between them.\u003c/p\u003e\n\u003ch2 data-xsweet-outline-level=\"1\"\u003e2.4. KEGG pathway analysis\u003c/h2\u003e\n\u003cp\u003eKyoto encyclopedia of genes and genomes (KEGG\u003cnote data-id=\"fn3\"/\u003e) database resource is an encyclopedia of genes and genomes for understanding high-level functions and utilities of the biological system from molecular-level information, especially large-scale molecular datasets generated by genome sequencing and other high-throughput experimental technologies. It assigns functional meanings to genes and genomes both at the molecular and higher levels. Molecular level functions are maintained in the KO (KEGG Orthology) database, while higher-level functions are defined in the forms of KEGG modules, KEGG pathway maps and BRITE hierarchies [\u003ca href=\"#_ENREF_14\"\u003e14\u003c/a\u003e].\u003c/p\u003e\n\u003ch2 data-xsweet-outline-level=\"1\"\u003e2.5. PPI network analysis\u003c/h2\u003e\n\u003cp\u003eIt is widely accepted that the interactions and partnerships between proteins are play important roles in biological regulation. The protein–protein interaction networks, which are constructed from either known or predicted interactions, provide us with topological summary of our research subjects.\u003c/p\u003e\n\u003cp\u003eA larger number of online resources contain this protein–protein interaction information. These interactions were generated either from experimental techniques [\u003ca href=\"#_ENREF_15\"\u003e15\u003c/a\u003e, \u003ca href=\"#_ENREF_16\"\u003e16\u003c/a\u003e] or from computational prediction [\u003ca href=\"#_ENREF_17\"\u003e17–19\u003c/a\u003e]. A group of databases integrate both known and predicted interactions, to provide much high comprehensiveness and coverage. Typical databases include GeneMANIA [\u003ca href=\"#_ENREF_20\"\u003e20\u003c/a\u003e], FunCoup [\u003ca href=\"#_ENREF_17\"\u003e17\u003c/a\u003e], I2D [\u003ca href=\"#_ENREF_21\"\u003e21\u003c/a\u003e], and STRING [\u003ca href=\"#_ENREF_22\"\u003e22\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eHighly complex biological functions are often undertaken by tightly interacted groups of proteins. PPI network was constructed in Cytoscape, and the significant modules were identified using the plug-in Molecular Complex Detection (MCODE).\u003c/p\u003e\n\u003ch2 data-xsweet-outline-level=\"1\"\u003e2.6. Target prediction and co-expression network \u003c/h2\u003e\n\u003cp\u003eTo further investigate the functional roles of circRNA, the miRNAs regulated by these circRNA and corresponding target genes were extracted from CIRCNET database. The circRNA-microRNA-mRNA co-expression networks were constructed based on this information by using Cytoscape.\u003c/p\u003e"},{"header":"Results ","content":"\u003ch2 data-xsweet-outline-level=\"1\"\u003e3.1. Differentially expressed genes\u003c/h2\u003e\n\u003cp\u003eDifferentially expressed genes (DEG) were identified from microarray data, using the criteria of adj. P. Value\u0026lt;0.05 and |log2FC|\u0026gt;1. A total of 291 circRNA genes were screened out between the PDAC tissues and paracancerous tissues after preprocessing of microarray data, including 128 up-regulated circRNAs and 163 down-regulated circRNAs. The expression levels of these dysregulated expression circRNAs were distinguishable and variations, which were demonstrated from the volcano plot (Figure 1A) and heatmap (Figure 1B). The top 10 up-regulated and down-regulated circRNAs were listed in Table 1. For example, hsa_circ_0006220 (TADA2A), hsa_circ_0000977 (NOL10) and hsa_circ_0001666 (FAM120B) were up-regulated with top magnitudes. Meanwhile, hsa_circ_0000518 (RPPH1) hsa_circ_0072088 (ZFR) and hsa_circ_0005273 (PTK2) were down-regulated with top magnitudes.\u003c/p\u003e\n\n\u003ch2 data-xsweet-outline-level=\"1\"\u003e3.2. Enrichment analysis of DEGs\u003c/h2\u003e\n\u003cp\u003eThe Gene Ontology (GO) enrichment analyses were performed on these 128 upregulated and 163 downregulated circRNAs respectively. Table 2 was the summary of GO enrichment analysis results, which listed the number of enriched GO terms at different significant level (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.10 or \u003cem\u003eP\u003c/em\u003e\u0026lt;0.05). Table 3 and Table 4 were top 10 GO terms (\u003cem\u003eP\u003c/em\u003e\u0026lt;0.05), respectively. GO enrichment analysis revealed that numerous genes were involved in the biological processes. For example, according to the gene ontology enrichment analysis results, the up-regulated circRNAs were enriched (\u003cem\u003eP\u003c/em\u003e \u0026lt;0.05) in 80 biological processes, including biological regulation, metabolic process, and gene expression, etc. Meanwhile, the downregulated circRNAs were enriched (\u003cem\u003eP\u003c/em\u003e \u0026lt;0.05) in 151 biological processes, including single-organism process, cell communication, and signal transduction, etc. These processes were associated with PDAC.\u003c/p\u003e\n\n\u003ch2 data-xsweet-outline-level=\"1\"\u003e3.3. KEGG pathway analysis\u003c/h2\u003e\n\u003cp\u003eKEGG pathway analysis results were listed in Table 5. The cutoff used for this analysis was \u003cem\u003eP\u003c/em\u003e\u0026lt;0.05. According to these results, the upregulated circRNAs were enriched in 2 pathways including cGMP-PKG signaling pathway, and HTLV-I infection, while the downregulated circRNAs were enriched in 10 pathways, including Protein processing in endoplasmic reticulum, insulin signaling pathway, regulation of actin cytoskeleton, etc.\u003c/p\u003e\n\n\u003ch2 data-xsweet-outline-level=\"1\"\u003e3.4. PPI network analysis and hub genes screening\u003c/h2\u003e\n\u003cp\u003eThe PPI (protein-protein interaction) network of the dysregulation genes were constructed by Cytoscape software, where the interaction information was extracted from the STRING database. As shown in Figure 2A, the red triangle nodes represent upregulated genes and green circular nodes represent downregulated genes, respectively.\u003c/p\u003e\n\u003cp\u003eThe PPI network was further analyzed by screening its hub genes and identifying significant modules. In the PPI networks, the nodes with high degree are defined as hub genes. The top 10 hub genes were ACACA, ACACB, GSK3B, LRRK2, PRKG1, UBQLN1, FOXO1, AXIN1, MTHFD1L and PTK2. The most significant hub proteins in the PPI network were ACACA (degree = 19) and ACACB (degree = 18). We also analyzed the PPI network using MCODE, which is a Cytoscape plug-in that finds clusters (or modules, highly interconnected regions) in a network. In PPI network, clusters are often protein complexes and parts of pathways. There were 3 modules identified in this PPI network (Figure 2A). The most significant modules contained ACACB, ACACA, AACS, ALDH7A1 and MTHFD1L. The other two modules contained GNAI2, MAP2K2, LRRK2, CAP1, EPS15L1, and EPS15.\u003c/p\u003e\n\n\u003ch2 data-xsweet-outline-level=\"1\"\u003e3.5. CircRNA-microRNA-mRNA co-expression network\u003c/h2\u003e\n\u003cp\u003eAs shown in Table 6, there were four genes identified as both hub genes and module genes in the PPI network analysis, including ACACA, MTHFD1L and LRRK2. The circRNA-microRNA-mRNA co-expression networks were constructed based on these genes.\u003c/p\u003e\n\u003cp\u003eThe miRNAs regulated by these circRNA and corresponding target genes were extracted from CIRCNET database. Due to limited space, no more than five top significant regulated miRNAs of each circRNA were reserved for the construction of co-expression network, and so do their target genes.\u003c/p\u003e\n\u003cp\u003eFigure 3 (A-C) are the circRNA-microRNA-mRNA networks of ACACA, LRRK2 and MTHFD1L, respectively. The purple nodes at the center of each network were the circRNA genes to be analyzed. The red nodes were the corresponding circRNA, the green nodes were miRNAs, and the light blue nodes were regulated gene. The purple edges linked circRNAs and their transcripts. The red edges linked transcripts and their regulated miRNAs. The gray edges linked miRNAs and their target gene.\u003c/p\u003e\n\u003cp\u003eAccording to Figure 4A, different transcripts of a specific circRNA could regulated the same miRNA, and different miRNA could regulate the same target gene. The more the transcripts, the more likely the co-regulation exists, and the more complex the network. For example, in the co-expression network of ACACA, both circ-ACACA.171 and circ-ACACA.75 regulated three common miRNAs, i.e. miR–137, miR–338–3p, and miR–376a–5p. Meanwhile, both miR–338–3p and miR–1288–3p regulated SLFN12L.\u003c/p\u003e\n\u003cp\u003eFor more complex regulatory networks with multiple circRNA, different circRNAs could co-regulate the same miRNA. For example, there are two circRNA in Figure 4 miR–508–5p is regulated by two transcripts of ACACB (circ-ACACB.74 and circ-ACACB.25) and one transcript of MTHFD1L (circ-MTHFD1L.11).\u003c/p\u003e\n\u003cp\u003eIn the circRNA-miRNA-mRNA regulatory network, there also existed closed loops. That is, circRNA regulated miRNA through its specific transcript, and miRNA may also regulate circRNA in turn, thus forming a closed loop structure. For example, in Figure 4, ACACB regulated miR–6849–3p through circ-ACACA.15, and miR–6849–3p in turn inhibits the expression of ACACB, thereby forming a closed loop.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003ePancreatic ductal adenocarcinoma is an aggressive malignant neoplasm with extremely high mortality rate, mainly because of difficult early diagnostic and poor prognosis. Current available therapeutic methods are almost ineffective [\u003ca href=\"#_ENREF_23\"\u003e23\u003c/a\u003e]. The potential improvement of the diagnosis may exist in the strictly molecular biomarkers [\u003ca href=\"#_ENREF_24\"\u003e24\u003c/a\u003e]. CircRNA is a new special kind of RNAs. Recent evidences revealed that circRNAs can function as miRNA sponges and affect disease by regulating gene expression.\u003c/p\u003e\n\u003cp\u003eIn the present study, we employed bioinformatics technology to investigate the underlying molecular mechanism of PDAC. Differentially expressed profiles of circRNAs in PDAC tissues were observed and validated compared with the paracancerous tissues, indicating possible involvement of these dysregulated circRNAs in the development of PDAC.\u003c/p\u003e\n\u003cp\u003eBy using microarray data, we observed a total of 291 circRNAs differentially expressed between PDAC tissues and paracancerous tissues, including 128 up-regulated circRNAs and 163 down-regulated circRNAs. Among these differentially expressed genes, hsa_circ_0006220, hsa_circ_0000977 and hsa_circ_0001666 were upregulated with top magnitudes, while hsa_circ_0000518, hsa_circ_0072088 and hsa_circ_0005273 were downregulated with top magnitudes. The differential expression levels of these genes may be related to the involvement in the transcription level regulation on PDAC.\u003c/p\u003e\n\u003cp\u003eCumulative evidence has demonstrated that co-expression genes usually participate in similar biological process. In order to better understand the interactions of these differentially expressed genes, we further applied GO and KEGG pathway analysis on them.\u003c/p\u003e\n\u003cp\u003eThe GO enrichment analysis results revealed that up-regulated DEGs were mainly involved metabolic process, biological regulation, and gene expression, and down-regulated DEGs were involved in cell communication, single-organism process, and signal transduction.\u003c/p\u003e\n\u003cp\u003eAs is well-known, the symptoms of the patients with cancer, such as cachexia, wasting syndrome, is related to metabolic disorders. Recent studies showed that, in the case of caloric deficiency, tumor induced changes in host metabolism, leading to tumor immunosuppression. For example, in pre-cachexia mice with PDA, IL6 reduced liver ketogenic ability by inhibiting PPAR alpha. When these mice challenged with caloric deficiency, it would lead to hypoketonemia, and induce the elevation of glucocorticoid levels. A variety of tumor immune pathways was inhibited by above stress response, and thus promoted the progression of pancreatic cancer [\u003ca href=\"#_ENREF_25\"\u003e25\u003c/a\u003e]. Furthermore, poor survival rates in patients with PDAC were attributed to abnormally high levels of metastasis. Study showed that the metabolic reprogramming of tumor infiltrating macrophages played a key role in PDAC metastasis [\u003ca href=\"#_ENREF_26\"\u003e26\u003c/a\u003e]. In addition, autophagy is required to maintain energy homeostasis by degrading unnecessary cellular components and molecules. In recent years, it has been found that autophagy can regulate the metabolism of tumor. Autophagy plays a crucial role in the maintenance of tumor survival. PDAC cells require autophagy and glutamine transporters to maintain intracellular glutamine levels [\u003ca href=\"#_ENREF_27\"\u003e27\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eTherefore, we hypothesized that the high expressed circRNAs may promote the metastasis of pancreatic cancer through various metabolic process, such as, stress response, metabolic reprogramming and glutamine metabolism.\u003c/p\u003e\n\u003cp\u003ePDAC is a highly metastatic tumor with poor prognosis, and intercellular communication is the key to metastasis [\u003ca href=\"#_ENREF_28\"\u003e28\u003c/a\u003e]. Research showed that PDAC-derived exosomes induced liver pre-metastasis niche formation in nude mice, and increased the load of liver metastasis. Kupffer cells uptaked PDAC-derived exosomes, resulting in transforming growth factor β (TGF-β) and upregulation of fibronectin production by hepatic stellate cells. This fibrotic microenvironment increases the number of bone marrow-derived macrophages. The authors found that macrophage migration inhibitory factor (MIF) was highly expressed in PDAC derived exosomes, and MIF promote metastasis, and liver metastasis before niche formation. It can be seen that the MIF of the exocrine body is initially transferred to the liver, which may be a prognostic indicator of PDAC liver metastasis [\u003ca href=\"#_ENREF_28\"\u003e28\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eThe low expression of circRNAs might be a tumor suppressor gene, which inhibit tumor pre-metastasis niche formation and tumor metastasis. Therefore, we can take this as the target for prevention and control, promote the expression of these circRNAs, block the cell mediated intercellular communication, and prevent the metastasis of pancreatic cancer.\u003c/p\u003e\n\u003cp\u003eAccording to the KEGG pathway analysis, the upregulated circRNAs were enriched cGMP-PKG signaling pathway, and HTLV-I infection, while the downregulated circRNAs were enriched in 10 pathways, including protein processing in endoplasmic reticulum, Insulin signaling pathway, regulation of actin cytoskeleton, etc. Recent evidence indicated that both cGMP-PKG and Insulin were play important roles in PDAC.\u003c/p\u003e\n\u003cp\u003eOur KEGG analysis results show that a large number of down-regulated circRNA of pancreatic cancer were enriched in the pathway of Protein processing in endoplasmic reticulum. Similarly, Peng et al. used the KEGG analysis and found that many endoplasmic reticulum (ER)-associated proteins were altered in solid pseudopapillary tumor of the pancreas (SPTP), suggesting that endoplasmic reticulum stress may play an important role in SPTP tumorigenesis. They also verified 7 proteins in the pathway by immunohistochemistry, including ERO1LB, TRIM1, BIP, SEC61B, P4HB, GRP94 and, PDIA4. Six of these proteins (except SEC61B) were consistent with the LC-MS/MS results [\u003ca href=\"#_ENREF_29\"\u003e29\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eOur KEGG analysis results also showed that the down regulated circRNAs of pancreatic cancer were enriched in insulin signaling pathway. It has been reported that hyperinsulinemia was a clear risk factor for pancreatic cancer, and an increase in hyperinsulinemia associated with obesity and type 2 diabetes heralded an increased incidence of cancer. The role of insulin in pancreatic cancer progression was worth to be further studied [\u003ca href=\"#_ENREF_30\"\u003e30\u003c/a\u003e]. They suggested that the overexpression of insulin signaling contributes to the survival and proliferation of human immortalized pancreatic ductal cells and metastatic pancreatic cancer cells, but does not affect normal pancreatic ductal cells. They also suggested that cell survival associated insulin pathway may be involved in the progression of pancreatic cancer [\u003ca href=\"#_ENREF_30\"\u003e30\u003c/a\u003e]. There were also literatures about insulin signaling pathway and chemotherapeutic resistance of pancreatic cancer. Ireland et al. found that tumor associated macrophages (TAM) and myofibroblasts activated insulin /IGF receptor by secreting IGF1–1 and 2, and directly promote chemoresistance of pancreatic cancer cells resistance. Analysis of biopsies from patients with pancreatic cancer showed that 72% of the patients’ tumor cells had expressed activated insulin / IGF receptor. Therefore, inhibition of IGF might contribute to the treatment of PDAC patients with chemotherapy resistance, and activation of insulin /IGF1R might be used as a biomarker for the identification of chemotherapy resistance [\u003ca href=\"#_ENREF_31\"\u003e31\u003c/a\u003e]. In addition, adaptor protein CrkII played an important role in the proliferation and invasion of some malignant tumors. However, the specific mechanism of insulin like growth factor 1 (IGF–1) -CrkII signal induced proliferation of PDAC was not clear. Studies have further demonstrated that the CrkII in insulin signaling pathway mediated IGF–1 signaling and affected PDAC through Erk1/2 and Akt pathway, suggesting that CrkII gene and protein could be used as an effective therapeutic targets for PDAC [\u003ca href=\"#_ENREF_32\"\u003e32\u003c/a\u003e].\u003c/p\u003e\n\u003cp\u003eWe further applied PPI network analysis to these aberrant expression genes. Ten hub genes with the top degree were obtained from the PPI network. We also identified three top significant modules by clustering. A total of eleven module genes were contain in these three module. Four genes were existed both as hub genes and module genes, including ACACA, MTHFD1L and LRRK2.\u003c/p\u003e\n\u003cp\u003eWe predicted the target genes of these four circRNA genes, and constructed circRNA-miRNA-Gene regulatory networks for them. On one hand, These genes regulated the expression of miRNAs by transcribing a variety of circRNAs, and further regulated the target genes through miRNAs. According to these regulatory networks, the more circRNAs, the more complex the regulation of miRNA and target genes. There existed multiple miRNAs regulated by the same circRNA. There also existed the same miRNA regulated by several circRNAs of a specific gene. In addition, circRNAs of different genes might regulate the same miRNA. On the other hand, On the other hand, miRNA also could bind to the target gene, and then regulated circRNAs via negative feedback, thus forming a closed loop. For example, circ-ACACB.74, circ-ACACB.25, and circ-MTHFD1L.101 targeted miR–508–5p simultaneously, and miR–508–5p regulated the expression of ACACB and MTHFD1L through the negative feedback. Therefore, bioinformatic analyses showed that circRNA targeting miR–508–5p might involve in the extremely complex regulation mechanism of PDAC. There exist literatures that miR–508–5p involves in the regulation mechanisms of liver gastric cancer and hepatocellular carcinoma. Shang Y. et al. reported that miR–508–5p play an important role in multidrug resistance (MDR) of gastric cancer by targeting ABCB1 and ZNRD1 [\u003ca href=\"#_ENREF_33\"\u003e33\u003c/a\u003e]. Further research suggested that the underlying mechanism was related to the miR–27b/CCNG1/P53/miR–508–5p axis, and it was possible to reverse MDR of gastric cancer by restoring the expression levels miR–27b and miR–508–5p [\u003ca href=\"#_ENREF_34\"\u003e34\u003c/a\u003e]. Yan H. et al. found out that miR–508–5p was aberrant expressed in hepatocellular carcinoma (HCC) [\u003ca href=\"#_ENREF_35\"\u003e35\u003c/a\u003e]. Wu et al. suggested that miR–508–5p might act as a tumor suppressor of HCC progression by targeting MESDC1 [\u003ca href=\"#_ENREF_36\"\u003e36\u003c/a\u003e]. Similar to gastric cancer and hepatocellular carcinoma, pancreatic adenocarcinoma is also a disease belong to the digestive system. We have reason to believe that miR–508–5 p may also be in pancreatic adenocarcinoma plays an important role. It is worth to study the problem of whether miR–508–5p participates in PDAC.\u003c/p\u003e"},{"header":"Declarations","content":"\u003ch3\u003eData Availability\u003c/h3\u003e\n\u003cp\u003eThe microarray data used to support the finding of this study have been deposited in the GEO database (dataset ID: GSE79634), which have been cited.\u003c/p\u003e\n\n\u003ch3\u003eConsent for publication\u003c/h3\u003e\n\u003cp\u003eThe authors confirm that written consents have been obtained from the patients, to publish this manuscript.\u003c/p\u003e\n\n\u003ch3\u003eCompeting interests\u003c/h3\u003e\n\u003cp\u003eThe authors declare that there are no competing interests in this work.\u003c/p\u003e\n\n\u003ch3\u003eAuthors’ contributions\u003c/h3\u003e\n\u003cp\u003eYanyan Tang wrote the manuscript and performed the analysis work. Ping Zhang designed this study and revised the manuscript. All the authors have read and approved the final manuscript.\u003c/p\u003e\n\n\u003ch3\u003eAcknowledgements\u003c/h3\u003e\n\u003cp\u003eThis study was supported by grants from the Natural Science Foundation of Hunan Province (2018JJ3634), the Humanities and Social Science Youth Fund of Ministry of Education of China (19YJCZH254), and the Scientific Research Project of the Health and Family Planning Commission of Hunan Province (B20180809).\u003c/p\u003e"},{"header":"Reference","content":"\u003cp\u003e1.Siegel RL, Miller KD and Jemal A. Cancer Statistics, 2017. CA: a cancer journal for clinicians. 2017; 67(1):7–30.\u003c/p\u003e\n\u003cp\u003e2.Chand S, O’Hayer K, Blanco FF, Winter JM and Brody JR. The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms. International journal of biological sciences. 2016; 12(3):273–282.\u003c/p\u003e\n\u003cp\u003e3.Sarnecka AK, Zagozda M and Durlik M. An Overview of Genetic Changes and Risk of Pancreatic Ductal Adenocarcinoma. 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Pharmacology. 2013; 92(3–4):167–174.\u003c/p\u003e\n\u003cp\u003e36.Wu SG, Huang YJ, Bao B, Wu LM, Dong J, Liu XH, Li ZH, Wang XY, Wang L, Chen BJ and Chen W. miR–508–5p acts as an anti-oncogene by targeting MESDC1 in hepatocellular carcinoma. Neoplasma. 2016; 64(1).\u003c/p\u003e"},{"header":"Notes","content":"\u003cdiv id=\"notes\"\u003e\u003cnote-container id=\"container-fn1\"\u003e\n\u003cp\u003e Gene Expression Omnibus (GEO, \u003ca href=\"http://www.ncbi.nlm.nih.gov/geo/\"\u003ehttp://www.ncbi.nlm.nih.gov/geo/\u003c/a\u003e)\u003c/p\u003e\u003c/note-container\u003e\u003cnote-container id=\"container-fn2\"\u003e\n\u003cp\u003e Gene Ontology Consortium, \u003ca href=\"http://www.geneontology.org/\"\u003ehttp://www.geneontology.org/\u003c/a\u003e\u003c/p\u003e\u003c/note-container\u003e\u003cnote-container id=\"container-fn3\"\u003e\n\u003cp\u003e Kyoto encyclopedia of genes and genomes (KEGG) \u003ca href=\"http://www.genome.jp/kegg/\"\u003ehttp://www.genome.jp/kegg/\u003c/a\u003e\u003c/p\u003e\u003c/note-container\u003e\u003c/div\u003e\u003c/body\u003e\u003c/html\u003e"},{"header":"Tables","content":"\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:center;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;line-height:150%;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 14px; line-height: 150%; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003eTable 1. Top 10 upregulated and downregulated circRNAs in the PDAC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"margin-left:5.6pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eID\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eadj. P. Val\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003et\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.55pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.535714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eB\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.5pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"11.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003elogFC\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eAlias\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eGene Symbol\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP002386\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e1.46E-09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e8.96494\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.535714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e15.32025\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0006220\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eTADA2A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e11.75923\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"11.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e6.156615\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0000977\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e5.730049\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0001666\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eFAM120B\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP002384\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e3.05E-09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e8.6488\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.535714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e14.36742\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0043278\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eTADA2A\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP004499\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e6.66086\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"11.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e3.455038\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0078297\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 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13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e5.33E-07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e3.135898\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0003600\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eSOX13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP000706\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e1.20E-05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e5.45481\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.535714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4.2992\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0013912\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ePOLR3C\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP001007\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e2.74095\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"11.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e2.978418\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0018909\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eVDAC2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP002451\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e1.50E-06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e2.73586\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0044436\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eKAT7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP001589\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e1.33E-06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e6.2597\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.535714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e6.86782\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0029634\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eZMYM2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP000018\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e15.18985\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"11.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-3.32345\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0000518\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 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13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4.61E-08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-2.93726\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0072088\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eZFR\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP004952\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e2.63E-07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-6.84074\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.535714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e8.72501\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0005273\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ePTK2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP000343\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e13.12182\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"11.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-2.65125\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0000520\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eRPPH1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP000385\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e6.05E-09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-2.47966\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0000511\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eRPPH1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP000315\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e9.34E-09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-8.15269\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.535714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e12.84926\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0000517\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eRPPH1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP004682\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e8.25959\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"11.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-2.42589\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0081188\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eSLC25A13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP003040\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e1.27E-07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-2.40068\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0006110\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eUSP34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP002376\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e7.35E-07\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-6.46544\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.535714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e7.52625\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"11.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-2.3365\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0003930\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGGNBP2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 70.7pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"16.785714285714285%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eASCRP003437\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.85pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"13.571428571428571%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e1.53E-05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 43.05pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.178571428571429%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-5.37134\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"10.535714285714286%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4.03481\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"11.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e-2.25906\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"21.607142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa_circ_0061749\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 13.5pt;vertical-align: top;\" valign=\"top\" width=\"15.714285714285714%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eBRWD1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;margin-left:.3in;text-indent:-.3in;line-height:150%;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eTable 2. Summary of GO enrichment analysis\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"3\" style=\"width: 73.8pt;border: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.62589928057554%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eDifferentially expressed circRNAs\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"6\" style=\"width: 343.5pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"82.37410071942446%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eThe number of enriched GO terms\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 114.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"33.4061135371179%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ebiological process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 114.6pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"33.4061135371179%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular component\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width: 114.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"33.18777292576419%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emolecular function\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.42105263157895%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ep\u0026lt;0.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.912280701754385%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ep\u0026lt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.42105263157895%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ep\u0026lt;0.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.912280701754385%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ep\u0026lt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.93859649122807%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ep\u0026lt;0.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"20.394736842105264%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ep\u0026lt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.8pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.689530685920577%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eup-regulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.16245487364621%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e135\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.274368231046932%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e80\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.16245487364621%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e28\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.274368231046932%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.649819494584838%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.787003610108304%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e21\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 73.8pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.689530685920577%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003edown-regulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.16245487364621%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e233\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.274368231046932%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e151\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.16245487364621%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e44\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.274368231046932%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e27\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 44.3pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"10.649819494584838%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e61\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.787003610108304%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eTable 3. Top 10 GO enrichment terms of upregulated circRNAs\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;border:none;\" width=\"549\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 55.25pt;border: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eOntology\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eAccession\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"44.72727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eName\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eGene count\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003e\u003cem\u003eP\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"10\" style=\"width: 55.25pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ebiological process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0065007\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"44.72727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ebiological regulation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e73\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0465\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0008152\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emetabolic process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0196\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n 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style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eorganic substance metabolic process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e71\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0118\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044237\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular metabolic process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e68\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0160\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044238\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eprimary metabolic process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e67\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0290\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043170\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emacromolecule metabolic process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e64\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0058\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044260\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular macromolecule metabolic process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e61\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0034\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0071840\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular component organization or biogenesis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e49\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0048\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0019222\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eregulation of metabolic process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0050\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0016043\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular component organization\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e48\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0051\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"10\" style=\"width: 55.25pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular component\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0005622\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"44.72727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eintracellular\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e88\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0192\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044424\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eintracellular part\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e87\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0123\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043226\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eorganelle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e82\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0299\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043229\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eintracellular organelle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e76\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0438\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0005737\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecytoplasm\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e69\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0496\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044446\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eintracellular organelle part\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0119\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044422\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eorganelle part\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e58\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0198\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0032991\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emacromolecular complex\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0421\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 3pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0070013\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 3pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eintracellular organelle lumen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 3pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 3pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0225\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043233\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eorganelle lumen\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0283\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"10\" style=\"width: 55.25pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emolecular function\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0005515\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"44.72727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eprotein binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.909090909090908%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e65\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.454545454545455%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0069\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0003824\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecatalytic activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e44\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0464\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0016740\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003etransferase activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0210\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0098772\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emolecular function regulator\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e17\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0059\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0005524\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eATP binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0472\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044877\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emacromolecular complex binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0349\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0030234\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eenzyme regulator activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0279\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0016772\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003etransferase activity, transferring phosphorus-containing groups\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0468\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0003712\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003etranscription cofactor activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0013\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 63.75pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0000989\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 184.3pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"51.680672268907564%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003etranscription factor activity, transcription factor binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.22689075630252%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.235294117647058%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0026\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;margin-left:.3in;text-indent:-.3in;line-height:150%;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eTable 4. Top 10 GO enrichment terms of downregulated circRNAs\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;border:none;\" width=\"568\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 62.35pt;border: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.612676056338028%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eOntology\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.725352112676056%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eAccession\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"41.725352112676056%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eName\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eGene count\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.443661971830986%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eP value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"10\" style=\"width: 62.35pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.612676056338028%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ebiological process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.725352112676056%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044699\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"41.725352112676056%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003esingle-organism process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e103\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.443661971830986%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0401\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044763\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003esingle-organism cellular process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e98\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0139\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0051716\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular response to stimulus\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e60\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0460\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0007154\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecell communication\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e57\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0158\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0023052\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003esignaling\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0233\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0071840\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular component organization or biogenesis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e56\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044700\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003esingle organism signaling\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0303\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular component organization\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e55\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0308\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0007165\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e52\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0290\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044767\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003esingle-organism developmental process\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e50\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0346\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"10\" style=\"width: 62.35pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.612676056338028%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecellular component\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.725352112676056%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044464\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"41.725352112676056%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecell part\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e121\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e121\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0004\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0005622\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e1.15E-06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044424\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eintracellular part\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 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width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043226\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eorganelle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e107\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e8.95E-05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0005737\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecytoplasm\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e104\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e2.06E-09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043229\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eintracellular organelle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e102\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4.72E-05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043227\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emembrane-bounded organelle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e102\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e7.86E-05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 3pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043231\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 3pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eintracellular membrane-bounded organelle\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 3pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e93\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;height: 3pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4.52E-04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0044444\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecytoplasmic part\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n 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style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e2.29E-09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"10\" style=\"width: 62.35pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"14.612676056338028%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emolecular function\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"16.725352112676056%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0005488\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"41.725352112676056%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: 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style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0428\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0005515\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eprotein binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0105\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0097159\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eorganic cyclic compound binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e54\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0110\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:1901363\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eheterocyclic compound binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0136\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0003824\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecatalytic activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e53\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0154\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043167\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eion binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0121\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0046872\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003emetal ion binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e41\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0083\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0043169\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecation binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e41\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0102\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0036094\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003esmall molecule binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e32\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e6.87E-04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 71.5pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.587628865979383%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGO:0000166\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 177.55pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"48.865979381443296%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003enucleotide binding\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.65pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.144329896907216%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e30\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.402061855670103%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e9.57E-04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;margin-left:.3in;text-indent:-.3in;line-height:150%;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eTable 5. KEGG analysis of differential expressed circRNAs\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;border:none;\" width=\"519\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 50.95pt;border: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.102119460500964%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.35pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.872832369942197%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eEntry\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"43.737957610789984%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eName\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.148362235067438%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eGene count\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: 1pt solid black;border-right: 1pt solid black;border-bottom: 1pt solid black;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.138728323699421%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003e\u003cem\u003eP\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"2\" style=\"width: 50.95pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.102119460500964%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eUp\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.872832369942197%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa04022\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"43.737957610789984%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ecGMP-PKG signaling pathway\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.148362235067438%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.138728323699421%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0085\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa05166\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eHTLV-I infection\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0356\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd rowspan=\"10\" style=\"width: 50.95pt;border-right: 1pt solid black;border-bottom: 1pt solid black;border-left: 1pt solid black;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.102119460500964%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eDown\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eregulated\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.872832369942197%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa04141\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"43.737957610789984%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eProtein processing in endoplasmic reticulum\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"17.148362235067438%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"12.138728323699421%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0004\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa04910\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eInsulin signaling pathway\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa04810\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eRegulation of actin cytoskeleton\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0075\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa04510\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eFocal adhesion\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0268\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa00620\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ePyruvate metabolism\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0042\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa00280\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eValine, leucine and isoleucine degradation\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0067\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa05213\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eEndometrial cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0088\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa04012\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eErbB signaling pathway\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0346\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa05215\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eProstate cancer\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0357\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.35pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"15.964523281596453%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ehsa00640\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 170.1pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"50.33259423503326%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003ePropanoate metabolism\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 66.6pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"19.733924611973393%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.95pt;border-top: none;border-left: none;border-bottom: 1pt solid black;border-right: 1pt solid black;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.968957871396896%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e0.0220\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:7.8pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003eTable 6. Hub and Module genes screened from PPI network\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellpadding=\"0\" cellspacing=\"0\" style=\"border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 47.95pt;border: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.267605633802816%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eType\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 297.65pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"69.8943661971831%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGene Symbol\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 80.5pt;border-top: 1pt solid windowtext;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-image: initial;border-left: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.838028169014084%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:center;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eIntersection\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 47.95pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"11.267605633802816%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eHub Genes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 297.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"69.8943661971831%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eACACA, GSK3B, LRRK2, PRKG1, UBQLN1, FOXO1, AXIN1, MTHFD1L, PTK2, UBA2, MAP3K5.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd rowspan=\"2\" style=\"width: 80.5pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"18.838028169014084%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eACACA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eLRRK2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eMTHFD1L\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 47.95pt;border-right: 1pt solid windowtext;border-bottom: 1pt solid windowtext;border-left: 1pt solid windowtext;border-image: initial;border-top: none;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"13.882863340563992%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eModule\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eGenes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 297.65pt;border-top: none;border-left: none;border-bottom: 1pt solid windowtext;border-right: 1pt solid windowtext;padding: 0in 5.4pt;vertical-align: top;\" valign=\"top\" width=\"86.11713665943601%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003eACACA, ACACB, AACS, ALDH7A1, MTHFD1L, GNAI2, MAP2K2, LRRK2, CAP1, EPS15L1, EPS15.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;line-height:150%;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:justify;font-size:14px;font-family:SimSun;line-height:150%;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-size: 14px;\"\u003e\u003cspan style=\"font-family: Verdana,Geneva,sans-serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;text-align:left;font-size:14px;font-family:\u0026quot;Calibri\u0026quot;,sans-serif;margin-left:.3in;text-indent:-.3in;line-height:150%;\"\u003e\u003cspan style=\"font-size: 14px; line-height: 150%; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"circular RNA; pancreatic carcinoma; expression profile; regulatory network ","lastPublishedDoi":"10.21203/rs.2.15313/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.15313/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Pancreatic ductal adenocarcinoma (PDAC) is one of the most common malignant tumor in digestive system. CircRNAs involve in lots of biological processes through interacting with miRNAs and their targeted mRNA. We obtained the circRNA gene expression profiles from Gene Expression Omnibus (GEO) and identified differentially expressed genes (DEGs) between PDAC samples and paracancerous tissues. Bioinformatics analyses, including GO analysis, KEGG pathway analysis and PPI network analysis, were conducted for further investigation. We also constructed circRNA‑microRNA-mRNA co-expression network. A total 291 differentially expressed circRNAs were screened out. The GO enrichment analysis revealed that up-regulated DEGs were mainly involved metabolic process, biological regulation, and gene expression, and down-regulated DEGs were involved in cell communication, single-organism process, and signal transduction. The KEGG pathway analysis, the upregulated circRNAs were enriched cGMP-PKG signaling pathway, and HTLV-I infection, while the downregulated circRNAs were enriched in protein processing in endoplasmic reticulum, insulin signaling pathway, regulation of actin cytoskeleton, etc. Four genes were identified from PPI network as both hub genes and module genes, and their circRNA‑miRNA-mRNA regulatory network also be constructed. Our study indicated possible involvement of dysregulated circRNAs in the development of PDAC and promoted our understanding of the underlying molecular mechanisms.","manuscriptTitle":"Network analyses of circular RNAs expression profiles and their hub genes in pancreatic ductal adenocarcinoma","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2019-09-27 23:08:44","doi":"10.21203/rs.2.15313/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"69024938-e6aa-4c51-843f-d0fa1b2c5441","owner":[],"postedDate":"September 27th, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":28900,"name":"Epigenetics \u0026 Genomics"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2019-09-27 23:08:44","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5979","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-5979","version":["v1"]},"buildId":"WrCJVZZCHTDjtuVLN7oU0","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}