Expression of E-cad and MMP-2 in Human Adenomyosis and Its Significance
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This study analyzed E-cadherin and MMP-2 expression in adenomyosis, finding significantly reduced E-cadherin in both ectopic and eutopic endometrium compared to normal tissue and elevated MMP-2 in ectopic lesions.
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Abstract
Objective: To study the expression of E-cad and MMP-2 in human adenomyosis and to explore the correlation between the expression and pathogenesis of human adenomyosis.Methods: Immunohistochemical S-P method was employed to detect the expression of E-cad and MMP-2 in 30 specimens of ectopic endometrium,eutopic endometrium of adenomyosis and 16 specimens of normal endometrium.Results: The expression of E-cad in ectopic and eutopic endometrium of adenomyosis were significantly lower than those of normal endometrium(P0.01,P0.05).The expression of MMP-2 in ectopic endometrium of adenomyosis were significantly higher than those of eutopic endometrium of adenomyosis and normal endometrium(P0.01,P0.01).Conclusion: The abnormal expression of E-cad and MMP-2 might be correlated with the pathogenesis of human adenomyosis.
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- last seen: 2026-06-10T17:14:06.276822+00:00
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