A Quality Measure for Repeating Multiple-Unit Spike Patterns

We propose a quality measure for spatio-temporal spike patterns (STPs) in multiple-neuron recordings. In such recordings, repeating STPs or pattern repetitions (PRs) are often found, with many of these generated by chance. To rule those out, statistical tests have been developed to discriminate the unlikely from the more likely PRs. This statistical problem is complicated by the fact that there are several obvious quality criteria for a PR, such as the size (the number of spikes) of the pattern and the number of its occurrences. Here, we propose a canonical way of combining several criteria (which we collect in the so-called signature of the pattern) into a single quality measure, based on the ‘unlikeliness’ of the pattern. This measure is defined mathematically, and a formula for its computation is derived for stationary spike trains. It can be used to compare PRs. Since spike trains are not stationary in practice, we discuss, for two experimental data sets, how well the stationary formula correlates with the defined quality measure as determined from simulations. The results encourage the use of the stationary formula or also some simpler, related formulas as ‘proxies’ for the quality, for the comparison of PRs and also for statistical tests that avoid the multiple testing problem incurred by using several quality criteria. Based on our results, we propose a few test statistics, i.e., random variables on the space of multi-unit spike trains with an appropriate null-hypothesis distribution, to evaluate STPs with less computational and sampling efforts.