Correlation between Yield and Reduced Mass of Raw Materials in Intermolecular and Intramolecular Cyclization Reactions

Correlation between yield and reduced mass of raw materials in intramolecular C-N, C-C, C-O coupling reactions and intramolecular/intermolecular Diels-Alder reactions was revealed. The regression equation was found to be the same as that of intermolecular reactions; yield = -0.1861 M AB /( n A n B n I )+100.0, where M AB is the reduced mass per mole and n A and n B are the total number of each reaction site in molecular A and molecular B in the reaction system, and n I is the number to distinguish whether it is a intramolecular reaction or intermolecular reaction.