Endometriosis of the pancreas presenting as a cystic pancreatic neoplasm with possible metastasis

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AI-generated summary by gemini-2.5-flash-lite, 2026-06-08

This case study details a rare instance of pancreatic endometriosis presenting as a cystic neoplasm, which was diagnosed through histopathological examination of a resected pancreatic mass.

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AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text

This paper reports a case of endometriosis involving the pancreas that presented as a cystic mass in the tail of the pancreas, prompting extensive diagnostic evaluation and major surgical resection. A definitive diagnosis was made through histopathological examination, which showed endometrial glands and stroma in the mass wall along with hemorrhagic fluid within the cystic lumen, consistent with an endometrial cyst affecting the pancreas and possible metastasis. The authors note that pancreatic endometriosis is extremely rare and emphasize histopathology as the confirmatory step, with the principal caveat being that the evidence is limited to a single case report. This paper is centrally about endometriosis — specifically pancreatic endometriosis mimicking a cystic pancreatic neoplasm.

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Abstract

The authors report a case of endometriosis that presented as a cystic mass in the tail of the pancreas, leading to extensive evaluation and ultimately a major surgical resection. The diagnosis was made by histopathological evaluation, revealing endometrial glands and stroma in the wall of the mass with hemorrhagic fluid in the cystic lumen, compatible with pancreatic involvement by an endometrial cyst.
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The Southern Medical Journal (SMJ) is the official, peer-reviewed journal of the Southern Medical Association. It has a multidisciplinary and inter-professional focus that covers a broad range of topics relevant to physicians and other healthcare specialists. SMJ // Article Case Report Endometriosis of the Pancreas Presenting as a Cystic Pancreatic Neoplasm with Possible Metastasis Abstract The authors report a case of endometriosis that presented as a cystic mass in the tail of the pancreas, leading to extensive evaluation and ultimately a major surgical resection. The diagnosis was made by histopathological evaluation, revealing endometrial glands and stroma in the wall of the mass with hemorrhagic fluid in the cystic lumen, compatible with pancreatic involvement by an endometrial cyst. Key Points * Endometriosis involving the pancreas is an extremely rare condition. * The pathogenic mechanisms of endometriosis in extrapelvic sites are numerous. * Histopathological demonstration of endometrial tissue in the mass helps confirm the diagnosis. * In a woman of childbearing age with intermittent abdominal pain and a cystic lesion in the pancreas on imaging studies, endometriosis must be considered in the differential diagnosis. This content is limited to qualifying members. Existing members, please login first If you have an existing account please login now to access this article or view purchase options. Purchase only this article ($25) Create a free account, then purchase this article to download or access it online for 24 hours. Purchase an SMJ online subscription ($75) Create a free account, then purchase a subscription to get complete access to all articles for a full year. Purchase a membership plan (fees vary) Premium members can access all articles plus recieve many more benefits. View all membership plans and benefit packages.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Pancreatic Cyst Pancreatic Diseases Adult Diagnosis, Differential Endometriosis Endometriosis Endometriosis Female Humans Pancreatic Cyst Pancreatic Diseases Pancreatic Diseases Pancreatic Diseases Pancreatic Neoplasms Pancreatic Neoplasms

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europepmc
last seen: 2026-08-26T06:08:41.316361+00:00
pubmed
last seen: 2026-05-13T22:12:26.305326+00:00
unpaywall
last seen: 2026-08-26T06:23:03.089193+00:00
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