USE OF STATINS IN DENTAL IMPLANTOLOGY AND THEIR IMPACT ON OSSEOINTEGRATION - A SYSTEMATIC REVIEW

Introduction: Statins are one of the most commonly used drugs for prevention of atherosclerosis and ischemic hearth disease. Statins have an antibacterial effect against oral pathogens, especially against Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Studies on animals which we analyzed in this article show that statins promote angiogenesis and osteoblast differentiation, as well they induce bone metabolism ,stimulates and improves better osseointegration way of titanium implants. Materials and methods: PubMed, Cochrane Central and Web of Science database search was performed for animal studies on statin effects on dental osseointegration. Results : Fifteen studies performed on laboratory animals were identified where statins were applied systemically, locally, orally, subcutaneously or intraosseously. Titan implants of different diameters were placed in tibia and femur of animals. Conclusion: Statins improved osseointegration and enhanced contact of implant surface with the newly formed bone, as well as significantly increased the volume of newly formed bone in lab animals.