Особливості гормонального гомеостазу в пацієнток із клімаксом на тлі ендометріозу

Features of hormonal homeostasis in women with climacteric syndrome associated with endometriosis DOI: https://doi.org/10.18370/2309-4117.2018.42.34-38Keywords: climacteric syndrome, endometriosis, endocrine homeostasisAbstract The aim of the study was searching of endocrine homeostasis in patients with climacteric changes against the backdrop of endometriosis and establishing the correlative relationships between the severity of menopausal symptoms and hormonal changes. 170 women with endometriosis were examined (of which 106 patients with endometriosis and climacteric manifestations – Group I, 64 with endometriosis without climacteric manifestations – Group II) and 153 women without endometriosis (of which 83 women with climacteric manifestations – Group III and 70 healthy women in the control Group IV). Women of all groups under study were divided into subgroups, depending on the age and phase of the menopause, and the concentration of sex steroid (estradiol, progesterone, testosterone) and gonadotropic (FSH and LH) hormones was investigated in the examined groups of patients prolactin, cortisol and cancer marker CA-125. As a result of the studies, installed the incidence of gonadotropic hormones (FSH, LH) and cortisol in the context of lowering the concentrations of sex steroid hormones compared with patients with climacteric syndrome (CS) without endometriosis was significantly higher in patients with CS in the context of endometriosis, which confirms the expressed asthenization in this contingent of women and early exhaustion they have an ovarian reserve. In this case, climacteric disorders develop in such women against the background of relative hyperestrogenemia, which indicates the involvement of other mechanisms for the development of CS in this category of women, in addition to estrogen deficiency, in particular hypercortisolemia. Therefore, summing up the above can be assumed that premenopause and climax, even physiological, are a stress factor for the woman’s body, which, along with the burdened comorbid state, causes significant stresses in the adaptive mechanisms and the launch of a stress-relieving system as a pathogenetic link in the development of moderate and severe forms of climacteric syndrome. References - Vovk, I.B., Khominska, Z.B., Zakharenko, N.F., et al. “Characteristics of hormonal status in women with endometriosis.” Woman Health 10.56 (2010): 162–4. - Zakharenko, N.F. “Clinical and anamnestic characteristics of women with different forms of endometriosis.” Pediatrics, Obstetrics and Gynecology: Sci. Pract. Journal 72.5 (2010): 97–104. - Ilovaiskaya, I.A. “Termination of menstrual function in the reproductive age and premature aging.” Gynecology endocrinology 1.102 (2015): 52–4. - Levkovich, M.A., Ermolova, N.V., Avanesova, T.G., Markaryan, I.V. “Modern views on the pathogenesis of genital endometriosis: the role of hormonal, immunological, genetic factors.” Tavrian med.-biol. Bulletin 20.2–2 (2017): 185–9. - Tatarchuk, Т.F., Zakharenko, N.F., Manoliak, I.P., et al. “Features of the manifestation of climacteric syndrome in women with endometriosis and possible ways of its correction.” Science Journal of the MOH of Ukraine 2 (2014): 71–7. - Tatarchuk, Т.F., Yefimenko, O.A., Tutchenko, T.N. “Stress and Involution of the Female Reproductive System.” Reproductive health of woman 5.34 (2007): 153–6. - Yureneva, S.V., Ermakova, E.I. “Menopausal disorders in women: pathogenesis, clinic, diagnosis, treatment, prevention.” MedicaMente 3.2 (2017): 32–8. - Inceboz, U. “Endometrios is after menopause womens.” Health (Lond) 11.5 (2015): 711–5. - Gemmell, L.C., Webster, K.E., Kirtley, S., et al. “The management of menopause in women with endometriosis: a systematic review.” Human Reproduction Update 23.4 (2017): 481–500. - DeZambotti, M., Trinder, J., Colrain, I.M., Baker, F.C. “Menstrual cycle – related variation in autonomic nervous system functioning in women in the early menopausal transition with and without in somnia disorder.” Psychoneuroendocrinology 75 (2017): 44–51. Downloads Published How to Cite Issue Section License Copyright (c) 2018 Н. Ф. Захаренко, Н. В. Коваленко, І. М. Ретунська This work is licensed under a Creative Commons Attribution 4.0 International License. Authors who publish with this journal agree to the following terms: - Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. - Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.