Microbiota-Immune-Brain Crosstalk Synthetic Biology Solutions for Neuroinflammatory Disorders

The gut microbiota plays a pivotal role in modulating immune responses and influencing brain function through the microbiota-immune-brain axis. Disruptions in this axis have been implicated in various neuroinflammatory disorders, including multiple sclerosis, Alzheimer's disease, and depression. Recent advancements in synthetic biology offer innovative strategies to engineer probiotics and microbial consortia capable of restoring homeostasis within this axis. This article reviews the current understanding of microbiota-immune-brain interactions and explores synthetic biology approaches aimed at mitigating neuroinflammation. By harnessing engineered microbes, we can develop targeted therapies that modulate immune responses and produce neuroactive compounds, offering promising avenues for treating neuroinflammatory conditions.