Analysis of clinical prognostic factors in bladder cancer-associated double primary cancer

Objective: This study aims to explore prognostic factors in bladder cancer-related DPC(double primary cancer). Method: Patients with bladder cancer admitted to the Department of Urology of the First Affiliated Hospital of Guangxi Medical University from November 2012 to October 2019 were screened. They were divided into simple bladder cancer ( n = 27) and bladder cancer-related DPC ( n = 27). Differences in sex, average age, smoking history, radiotherapy history, intravenous chemotherapy history, SII, NLR, PLR, PNI, and serum tumor markers between the two groups were analyzed. Factors related to prognosis evaluation were determined. Results: : Smoking history, radiotherapy history, intravenous chemotherapy history, SII, NLR, PLR, and PNI were significantly different between the simple bladder cancer group and the bladder cancer-related DPC group ( P 0.05). In the univariate analysis, patient type, SII, PLR, NLR, and PNI had significant effects on survival rate ( P <0.05). Multivariate analysis showed that the type of patient was an independent factor affecting survival. The survival rate of patients with bladder cancer-related DPC was lower than that of patients with simple bladder cancer ( P <0.001). Conclusion: The incidence of DPC associated with bladder cancer is positively correlated with the history of smoking, radiotherapy, and intravenous chemotherapy. Dynamic monitoring of changes in SII, NLR, PLR and PNI after treatment of the first primary cancer is helpful to evaluate the risk of DPC in patients. The prognosis of patients with bladder cancer-related DPC is worse than that of patients with simple bladder cancer.