Comparative Study of the Biochemical Behavior of some Highly Toxic Minerals on Selenosis in Rats

Objective: An investigation of the potential influences of As, Hg, Tl and Pb on Se metabolism, which can suggest new drugs to cope the poisonousness of Se. Methods: : Chronic cases were carried out with the nursing of rats with a purified diet of water-soluble vitamin mix, fat-soluble vitamin mix, saccharides, oil, and salts. One week after the basic diet, the rats taken Se have received diets containing 10 ppm of the element as sodium selenite or selenate added in the salts. Result: As, Hg, and Tl were repressed the volatized Se excreted from the lungs. As has assisted the biliary excretion of Se and inhibited the chronic selenosis. Tl has increased the retention of Se in the liver and kidney, but, had no chronic effect on the amount of Se deposited in all the studied tissues. Similarly, Hg has increased the retention of Se but in the spleen and carcass of rats indicating to the high Se concentration in blood. Hg and Tl have inhibited the Se in urine. Conclusion: No effects of the doses rich in As, Hg, and Tl on the Se excretion in fecal. Even though, we suggest As as a possible medication to chronic selenosis.