Disease Burden Among Canadian Women With Symptomatic Uterine Fibroids: Interim Results of CAPTURE [1H]

INTRODUCTION: The CAnadian women wiTh Uterine fibroids (UF) REgistry (CAPTURE) was designed to document real-world data about disease burden, management, and outcomes of symptomatic UFs. METHODS: This up to 2-year, prospective, observational, practice-based study will include ∼1000 premenopausal adult women referred for treatment of symptomatic UF at ≥12 clinical practice sites across Canada. RESULTS: Among 461 women enrolled to date, 64.6% were White, with mean ± SD age of 43.3 ± 6.9 years and BMI of 26.4 ± 6.2 kg/m 2 . Comorbidities included anemia (43.4%), known/suspected endometriosis (7.2%), hypertension (6.3%), and diabetes (2.4%). Most frequently reported symptoms (>50%) included heavy menstrual bleeding (82.0%), pelvic discomfort (80.0%), dysmenorrhea (77.8%), urinary frequency (73.6%), pelvic pain (68.5%), low back pain (62.5%), bulk symptoms (60.2%), and urinary urgency (59.6%). Time since first symptoms was < 1 year for 14.2%, 1 to < 3 years for 25.1%, 3 to < 5 years for 16.4%, and ≥5 years for 44.3%. MRI or ultrasound indicated 36.2% had 1 UF, 34.1% had 2 to 4, and 29.6% had ≥5. At baseline, 88% reported bleeding in the past 3 months with mean ± SD Aberdeen menorrhagia severity scale score of 34.9 ± 20. As measured by the UF symptom and quality of life questionnaire (UFS-QoL), mean ± SD symptom severity was 48.7 ± 22.7 and QoL was 52.3 ± 25.1. CONCLUSION: CAPTURE is the first registry worldwide to examine real-world practice-based management of women with UF. The 461 patients enrolled to date, of the targeted 1000, demonstrate a high burden of disease and a poor QoL. Impact of interventions on QoL will be evaluated at follow-up visits.