OpTiles: An R Package for Adaptive Tiling and Methylation Variability Profiling

Summary OpTiles is an R package that dynamically defines tiling windows based on the distribution of sequenced CpGs, addressing the limitations of traditional fixed-tiling approaches in targeted methylation datasets. By integrating CpG density with intra-region methylation variability, it provides a reliability metric and extended functionality for annotating, prioritizing, and interpreting complex methylation data. Availability OpTiles is implemented in R and source code is freely available at https://github.com/fhaive/OpTiles . Data are available on Zenodo at https://doi.org/10.5281/zenodo.16961293 Contact [email protected]