Assessment of Immunization Status in Duchenne and Becker Muscular Dystrophy Cases and Vaccine Recommendations

Assessment of Immunization Status in Duchenne and Becker Muscular Dystrophy Cases and Vaccine Recommendations | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Assessment of Immunization Status in Duchenne and Becker Muscular Dystrophy Cases and Vaccine Recommendations Gizem Doğan, Figen Baydan, Yiğithan Güzin, Gamze Sarıkaya Uzan This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7978965/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are the most common neuromuscular diseases in childhood. Since respiratory system involvement is one of the major causes of mortality, vaccinations play a crucial role. In this study, we aimed to assess the vaccination status of our patients diagnosed with DMD and BMD. Methods This single-center study included patients with DMD and BMD who were followed up at the Neuromuscular Diseases Center of Tepecik Training and Research Hospital in İzmir, Türkiye. The vaccination status of these patients according to the Turkish National Vaccination Program, as well as their additional influenza vaccination status, was evaluated. Results A total of 160 patients were included in the study. We found that 23% of the cases had missing vaccines in the national vaccination program. The rate of those who received regular influenza vaccination was only 8%. The rate of hospitalization due to infection in the past year was 8%, and influenza was identified as the etiology in 80% of these cases. The most frequently missing vaccines in the national vaccination program were as follows: 18% (n = 30) varicella, 17% (n = 28) hepatitis A, 15% (n = 25) measles–mumps–rubella (MMR), 12% (n = 20) pneumococcal conjugate vaccine (PCV), 8% (n = 13) oral polio vaccine (OPV), 0.25% (n = 4) Bacillus Calmette–Guérin (BCG), and 0.25% (n = 4) diphtheria–tetanus toxoids–acellular pertussis–inactivated poliovirus vaccine (DTaP-IPV). Conclusions In our study, we found that vaccination rates among DMD and BMD patients were lower compared to the healthy population. The vaccination status of patients should be assessed, and appropriate vaccine administration should be ensured through proper recommendations. immunization status influenza vaccine muscular dystrophies vaccination Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7978965","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":537905048,"identity":"78b70e32-ccc4-4bf4-a92d-00ed5b015162","order_by":0,"name":"Gizem 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Recommendations","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"immunization status, influenza vaccine, muscular dystrophies, vaccination","lastPublishedDoi":"10.21203/rs.3.rs-7978965/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7978965/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003ePurpose\u003c/h2\u003e\u003cp\u003eDuchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are the most common neuromuscular diseases in childhood. Since respiratory system involvement is one of the major causes of mortality, vaccinations play a crucial role. In this study, we aimed to assess the vaccination status of our patients diagnosed with DMD and BMD.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e\u003cp\u003e This single-center study included patients with DMD and BMD who were followed up at the Neuromuscular Diseases Center of Tepecik Training and Research Hospital in İzmir, T\u0026uuml;rkiye. The vaccination status of these patients according to the Turkish National Vaccination Program, as well as their additional influenza vaccination status, was evaluated.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eA total of 160 patients were included in the study. We found that 23% of the cases had missing vaccines in the national vaccination program. The rate of those who received regular influenza vaccination was only 8%. The rate of hospitalization due to infection in the past year was 8%, and influenza was identified as the etiology in 80% of these cases. The most frequently missing vaccines in the national vaccination program were as follows: 18% (n\u0026thinsp;=\u0026thinsp;30) varicella, 17% (n\u0026thinsp;=\u0026thinsp;28) hepatitis A, 15% (n\u0026thinsp;=\u0026thinsp;25) measles\u0026ndash;mumps\u0026ndash;rubella (MMR), 12% (n\u0026thinsp;=\u0026thinsp;20) pneumococcal conjugate vaccine (PCV), 8% (n\u0026thinsp;=\u0026thinsp;13) oral polio vaccine (OPV), 0.25% (n\u0026thinsp;=\u0026thinsp;4) Bacillus Calmette\u0026ndash;Gu\u0026eacute;rin (BCG), and 0.25% (n\u0026thinsp;=\u0026thinsp;4) diphtheria\u0026ndash;tetanus toxoids\u0026ndash;acellular pertussis\u0026ndash;inactivated poliovirus vaccine (DTaP-IPV).\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e\u003cp\u003eIn our study, we found that vaccination rates among DMD and BMD patients were lower compared to the healthy population. The vaccination status of patients should be assessed, and appropriate vaccine administration should be ensured through proper recommendations.\u003c/p\u003e","manuscriptTitle":"Assessment of Immunization Status in Duchenne and Becker Muscular Dystrophy Cases and Vaccine Recommendations","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-03 10:13:10","doi":"10.21203/rs.3.rs-7978965/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"664eed5f-dbc2-44bd-b38e-8ffef33631c0","owner":[],"postedDate":"November 3rd, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-11-04T16:38:48+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-03 10:13:10","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7978965","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7978965","identity":"rs-7978965","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}