Uses of half-dose gonadotropin-releasing hormone agonist with different treatment cycles after conservative laparoscopic surgery in the treatment of endometriosis

To explore the efficacy of using gonadotropin-releasing hormone agonist (GnRH-a) with different cycles after conservative laparoscopic surgery in the treatment of endometriosis. Research was conducted on 108 patients with endometriosis Ⅲ or Ⅳ diagnosed by conservative laparoscopy from January 2010 to June 2011. Among them, 57 patients (group A) were managed with GnRH-a postoperatively for 3 months and the others (group B) 6 months. Clinical efficacy, relapse rate and pregnancy rate after withdrawal were compared between two groups. The clinical efficacy rate of groups A and B were 73.7% and 90.2% respectively. And there were significant statistical differences between them. However, the relapse rate of groups A and B were 14.0% and 5.9% and the pregnancy rate of two groups 45.0% and 4/12 respectively. And there were no statistical differences. A 6-month regimen of GnRH-a can reduce and delay the recurrence of endometriosis and improve the clinical efficacy. A short-term dosing of GnRH-a is indicated for those patients with fertility requirements. Key words: Endometriosis; Gonadotropin-releasing hormone