Viral kinetics during acute chikungunya virus infection

Viral kinetics during acute chikungunya virus infection | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Journal of Medical Virology This is a preprint and has not been peer reviewed. Data may be preliminary. 26 January 2025 V1 Latest version Share on Viral kinetics during acute chikungunya virus infection Authors : Tey Putita Ou 0000-0001-8179-1382 , Sopheak Sorn , Kunthy Nguon , Saraden In , Sreymom Ken , Sowath Ly , Claude Flamand , Nicolas Voirin 0000-0003-3317-056X , Marie Mandron , Hugh Watson 0000-0002-6931-3158 , and Veasna Duong 0000-0003-0353-1678 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.173789972.28656366/v1 450 views 158 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Chikungunya virus (CHIKV), an arthritogenic alphavirus, is a significant public health threat in endemic and newly affected regions. This study investigates viral kinetics, immune responses, and the potential of monoclonal antibody (mAb) therapies to mitigate viraemia and transmission during acute CHIKV infection, providing novel insights into early intervention strategies. Using data from 29 patients in Cambodia, serial sampling and viral load quantification revealed that the population-average peak viral load occurred approximately 1.87 days prior to symptom onset. Children demonstrated higher peak viral loads and faster replication rates compared to adults, although symptom severity and burden were similar across age groups. IgM antibodies appeared earlier in adults (median: 4.1 days) than in children (median: 5.1 days; p = 0.036). C-reactive protein (CRP) levels were transiently elevated in about 50% of patients but showed no correlation with disease severity. Mathematical modeling highlighted that prophylactic mAb therapies, when administered three days before symptoms onset, could substantially reduce viral load and potentially prevent detectable viraemia. While these findings underscore the potential of mAbs as an early therapeutic strategy, further studies are necessary to evaluate the robustness of these results and assess their practical implications to curb CHIKV outbreaks by minimizing viraemia and pre-symptomatic transmission. Supplementary Material File (2. chikv viral kinetics_final_submission version.docx) Download 2.67 MB Information & Authors Information Version history V1 Version 1 26 January 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Journal of Medical Virology Keywords biostatistics & bioinformatics computer modeling disease control immunoprophylaxis infection Authors Affiliations Tey Putita Ou 0000-0001-8179-1382 Institut Pasteur du Cambodge View all articles by this author Sopheak Sorn Institut Pasteur du Cambodge View all articles by this author Kunthy Nguon Institut Pasteur du Cambodge View all articles by this author Saraden In Institut Pasteur du Cambodge View all articles by this author Sreymom Ken Institut Pasteur du Cambodge View all articles by this author Sowath Ly Institut Pasteur du Cambodge View all articles by this author Claude Flamand Institut Pasteur du Cambodge View all articles by this author Nicolas Voirin 0000-0003-3317-056X Epimod View all articles by this author Marie Mandron Evotec France SAS View all articles by this author Hugh Watson 0000-0002-6931-3158 Evotec France SAS View all articles by this author Veasna Duong 0000-0003-0353-1678 [email protected] Institut Pasteur du Cambodge View all articles by this author Metrics & Citations Metrics Article Usage 450 views 158 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Tey Putita Ou, Sopheak Sorn, Kunthy Nguon, et al. Viral kinetics during acute chikungunya virus infection. Authorea . 26 January 2025. DOI: https://doi.org/10.22541/au.173789972.28656366/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! 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