Metabolic and carbohydrate characteristics of different phenotypes of polycystic ovary syndrome.

Ebru Çelik, İlgın Türkçüoğlu, Barış Ata, Abdullah Karaer, Kırıcı P, Eraslan S, Taşkapan Ç, Berker B
Journal of the Turkish German Gynecological Association · 2016 · doi:10.5152/jtgga.2016.16133 · PMID:27990089 · PMC5147759
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This retrospective cross-sectional study evaluated metabolic and cardiovascular risk factors in 687 women with polycystic ovary syndrome, comparing those diagnosed under Androgen Excess Society criteria against normoandrogenemic PCOS patients. The analysis revealed that women meeting the Androgen Excess definition had a significantly higher prevalence of metabolic syndrome and low high-density lipoprotein cholesterol compared to their normoandrogenemic counterparts. While glucose intolerance did not differ significantly between groups, the findings indicate that cardiovascular risk profiles vary substantially across different PCOS phenotypes defined by Rotterdam criteria. This paper is centrally about polycystic ovary syndrome; relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

ObjectiveTo compare the prevalence of various metabolic and cardiovascular risk factors and insulin resistance between polycystic ovary syndrome (PCOS) patients with or without hyperandrogenism.Material and methodsThis is a retrospective cross-sectional study involving women with PCOS as diagnosed according to the Androgen Excess (AE) Society definition (n=504) and women with normoandrogenemic PCOS (n=183). Anthropometrics, lipid profile, glucose, insulin, oral glucose tolerance test (OGTT), and reproductive hormone levels were evaluated.ResultsWomen with PCOS diagnosed according to the AE Society had a significantly higher prevalence of metabolic syndrome compared with the normoandrogenemic PCOS phenotype: odds ratio (OR) 2.95 [95% confidence interval (CI) 1.21-7.21]. There was no significant difference in the prevalence glucose intolerance test between the groups [OR: 2.15, 95% CI 0.71-6.56]. The prevalence of low high density lipoprotein (HDL)-cholesterol in the group under the AE-PCOS Society criteria was higher than that of the normoandrogenemic PCOS group [OR: 2.82, 95%CI 1.29-3.36].ConclusionThe risks of metabolic syndrome and cardiovascular disease may vary among the phenotypes of PCOS based on the Rotterdam criteria. This new data may be of reference in informing women with PCOS, although further prospective studies are needed to validate this proposition.
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Abstract

Objective: To compare the prevalence of various metabolic and cardiovascular risk factors and insulin resistance between polycystic ovary syndrome (PCOS) patients with or without hyperandrogenism.

Material and methods

This is a retrospective cross-sectional study involving women with PCOS as diagnosed according to the Androgen Excess (AE) Society definition (n=504) and women with normoandrogenemic PCOS (n=183). Anthropometrics, lipid profile, glucose, insulin, oral glucose tolerance test (OGTT), and reproductive hormone levels were evaluated.

Results

Women with PCOS diagnosed according to the AE Society had a significantly higher prevalence of metabolic syndrome compared with the normoandrogenemic PCOS phenotype: odds ratio (OR) 2.95 [95% confidence interval (CI) 1.21–7.21]. There was no significant difference in the prevalence glucose intolerance test between the groups [OR: 2.15, 95% CI 0.71–6.56]. The prevalence of low high density lipoprotein (HDL)-cholesterol in the group under the AE-PCOS Society criteria was higher than that of the normoandrogenemic PCOS group [OR: 2.82, 95%CI 1.29–3.36].

Conclusion

The risks of metabolic syndrome and cardiovascular disease may vary among the phenotypes of PCOS based on the Rotterdam criteria. This new data may be of reference in informing women with PCOS, although further prospective studies are needed to validate this proposition.

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