Endocrine disruptors in utero cause ovarian damages linked to endometriosis
Prenatal exposure to endocrine disruptor bisphenol A in mice led to ovarian damage, characterized by reduced primordial and developing follicles and increased atretic follicles, linked to an endometriosis-like phenotype.
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The study used timed pregnant Balb-C mice treated with bisphenol A (BPA) from day 1 of gestation through 7 days after delivery, and then assessed offspring ovaries in their entirety three months later. Compared with untreated controls, BPA-exposed animals had significantly fewer primordial and developing follicles and significantly more atretic follicles. The authors also reported that mice displaying an endometriosis-like phenotype had more severe ovarian impairment in follicle numbers than other BPA-exposed mice, concluding that prenatal BPA exposure produced a combined phenotype involving ovarian lesions and endometriosis. This paper is centrally about endometriosis — it links prenatal bisphenol A exposure to ovarian damage alongside an endometriosis-like phenotype in mice.
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Cited by (9)
- The Role of Adenogenesis Factors in the Pathogenesis of Endometriosis 2025
- Endocrine Disruption in Women: A Cause of PCOS, Early Puberty, or Endometriosis 2023
- Endocrine Disruptor Compounds in Environment: Focus on Women's Reproductive Health and Endometriosis 2023
- Environmental Risk Factors for Endometriosis: An Umbrella Review of a Meta-Analysis of 354 Observational Studies With Over 5 Million Populations 2021
- The risk of endometriosis after exposure to endocrine-disrupting chemicals: a meta-analysis of 30 epidemiology studies 2019
- Anti-mullerian hormone is expressed by endometriosis tissues and induces cell cycle arrest and apoptosis in endometriosis cells 2014
- Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals 2014
- Transcriptional profiling of endometriosis tissues identifies genes related to organogenesis defects 2013
- <i>In utero</i> exposure and endometriosis 2013
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