Modulating the oxidative and inflammatory response: The therapeutic potential of vasopressin in ovarian torsion–detorsion injury

Hany A. Elkattawy, Shimaa Hadhoud, Rania Naguib, Amira Mokhtar Gobran, Eslam Kamal Fahmy, Noura Mostafa Mohamed, Naser A El Sawy, Nada Mohamed Mohamed Soliman, Sahar K. Ali
In: Tissue and Cell · 2026 · vol. 101 , pp. 103454 · doi:10.1016/j.tice.2026.103454 · PMID:41855922 · W7135025147
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Vasopressin administration to rats after ovarian torsion-detorsion mitigated oxidative stress, inflammation, and apoptosis, suggesting therapeutic potential for ovarian ischemia-reperfusion injury.

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Abstract

BackgroundOvarian torsion is a serious emergency that can lead to female infertility. Vasopressin (VP) is a potent vasoconstrictor with potential anti-inflammatory properties.ObjectivesThis study aimed to evaluate the protective effect of VP administration on damage caused by ovarian torsion-detorsion in rats.Materials and methodsTwenty-four mature female albino Wistar rats were randomly divided into four groups (n = 6): group 1 (control), group 2 (sham, surgery without torsion-detorsion), group 3 (torsion-detorsion surgery without treatment) (TD), and group 4 (torsion-detorsion surgery with vasopressin) (VP). VP (0.1 μg/kg) was administered via the tail vein 15 min before surgery, then twice daily for 15 days. After treatment, the rats were euthanized, and biochemical parameters were measured using commercial kits. Levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) were measured. Additionally, mRNA levels of p53, BAX, BCL-2, Caspase-3, and SERCA2a were evaluated by real-time PCR, along with SIRT1 and NF-κB expression in ovarian tissue. Histological changes of the ovary were examined using hematoxylin and eosin (H&E) staining and Masson's trichrome.ResultsOvarian torsion-detorsion induced oxidative stress, increasing MDA production while decreasing the activities of GSH-Px and SOD. Furthermore, ovarian tissue showed increased levels of IL-1β, IL-6, TNF-α, and NF-κB, along with higher mRNA expression of BAX, p53, and caspase-3, and decreased BCL-2, indicating heightened inflammatory and apoptotic activity. The findings indicated that administering VP (0.1 μg/kg) mitigated these oxidative damage, inflammation, and programmed cell death, leveraging its antioxidant and anti-inflammatory effects.ConclusionThe study suggests a potential protective role of vasopressin (VP) in mitigating histopathological changes, inflammatory responses, and oxidative stress following ovarian torsion detorsion in rats. Consequently, VP could be a potential therapeutic option for ovarian ischemia-reperfusion injury.

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SciLite annotations

chemicals 4
vasopressin vasopressin vasopressin haematoxylin
organisms 3
rattus sp. zitter rats rattus sp.

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