Florfenicol Sustained-release Granules: An in Vitro release and pharmacokinetics study in pigs

The aim of the present study was to synthesize and characterize florfenicol sustained-release granules (FSRGs) in vitro and in vivo . FSRGs were synthesized using monostearate, polyethylene glycol 4000 and amylum starch. In vitro dissolution profiles were studied using the rotating basket method in pH1.2 HCl solution and pH 4.3 acetate buffer. Twenty-four male healthy Landrace×Yorkshire pigs were equally divided into three groups and administered a 20 mg/kg i.v bolus of florfenicol solution and dosed orally with FSRGs in fasted and fed condition. The Higuchi model was the best fit for the drug release profile in pH1.2 and pH 4.3 media and the mechanism of drug dissolution was governed by both diffusion and dissolution. We established a level A in vitro - in vivo correlation for FSRGs and the in vivo profile of the FSRGs can be estimated by the in vitro drug release