The use of retinoic acid for the treatment of endometriosis
Retinoic acid has demonstrated potential to suppress endometriosis development and lesion growth while promoting macrophage differentiation in animal models.
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This short article discusses the use of retinoic acid (a retinoid) as a potential treatment for endometriosis, synthesizing prior findings from experimental and mechanistic studies rather than reporting original experiments. It highlights evidence that retinoic acid can regulate endometriotic stromal cell growth and suppress lesion development, including effects on associated molecular pathways (e.g., Beclin1 upregulation) and immune-related processes such as cytokine secretion and macrophage differentiation. The main limitation is that the piece is not an original study with new human or animal data from the authors, and it does not provide new clinical outcomes. This paper is centrally about endometriosis — it specifically focuses on the potential therapeutic use of retinoic acid for treating endometriosis.
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References (7)
- Endometriosis: pathogenesis and treatment via openalex
- Pathogenesis of Endometriosis: Roles of Retinoids and Inflammatory Pathways via openalex
- Retinoic acid has the potential to suppress endometriosis development via openalex
- Retinoic acid regulates endometriotic stromal cell growth through upregulation of Beclin1 via openalex
- Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis via openalex
- The Efficacy of Bevacizumab, Sorafenib, and Retinoic Acid on Rat Endometriosis Model via openalex
- W2175100915 via openalex
Cited by (5)
- Vitamin A and pregnancy: myths and reality; prospects for the use in patients with endometriosis. A review 2021
- Pain 2021
- A comprehensive review of hormonal and biological therapies for endometriosis: latest developments 2019
- Current and emerging treatment options for endometriosis 2018
- Investigational drugs for the treatment of endometriosis, an update on recent developments 2018
Source provenance
- europepmc
- last seen: 2026-08-01T06:07:04.264727+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:19:49.066213+00:00
- unpaywall
- last seen: 2026-06-13T06:42:57.164913+00:00