The use of retinoic acid for the treatment of endometriosis

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AI-generated summary by claude@2026-06+body, 2026-06-11

Retinoic acid has demonstrated potential to suppress endometriosis development and lesion growth while promoting macrophage differentiation in animal models.

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This short article discusses the use of retinoic acid (a retinoid) as a potential treatment for endometriosis, synthesizing prior findings from experimental and mechanistic studies rather than reporting original experiments. It highlights evidence that retinoic acid can regulate endometriotic stromal cell growth and suppress lesion development, including effects on associated molecular pathways (e.g., Beclin1 upregulation) and immune-related processes such as cytokine secretion and macrophage differentiation. The main limitation is that the piece is not an original study with new human or animal data from the authors, and it does not provide new clinical outcomes. This paper is centrally about endometriosis — it specifically focuses on the potential therapeutic use of retinoic acid for treating endometriosis.

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References Lu H, Li S, Wu Q (2018) Retinoic acid regulates endometriotic stromal cell growth through upregulation of Beclin1. Arch Gynecol Obstet 297(1):93–99. https://doi.org/10.1007/s00404-017-4549-8 Taylor RN, Kane MA, Sidell N (2015) Pathogenesis of endometriosis: roles of retinoids and inflammatory pathways. Semin Reprod Med 33(4):246–256. https://doi.org/10.1055/s-0035-1554920 Hatice O, Abdullah B, Gökhan A, Remzi A, Ozlem Bozoklu A, Mehmet Ilkay K (2012) The efficacy of bevacizumab, sorafenib, and retinoic acid on rat endometriosis model. Reprod Sci 20(1):26–32. https://doi.org/10.1177/1933719112452941 Wieser F, Wu J, Shen Z, Taylor RN, Sidell N (2012) Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis. Fertil Steril 97(6):1430–1437. https://doi.org/10.1016/j.fertnstert.2012.03.004 Vercellini P, Vigano P, Somigliana E, Fedele L (2014) Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol 10(5):261–275. https://doi.org/10.1038/nrendo.2013.255 Yamagata Y, Takaki E, Shinagawa M, Okada M, Jozaki K, Lee L, Sato S, Maekawa R, Taketani T, Asada H, Tamura H, Nakai A, Sugino N (2015) Retinoic acid has the potential to suppress endometriosis development. J Ovarian Res 8:49. https://doi.org/10.1186/s13048-015-0179-6 Tafi E, Leone Roberti Maggiore U, Alessandri F, Bogliolo S, Gardella B, Vellone VG, Grillo F, Mastracci L, Ferrero S (2015) Advances in pharmacotherapy for treating endometriosis. Expert Opin Pharmacother 16(16):2465–2483. https://doi.org/10.1517/14656566.2015.1085510 Author information Authors and Affiliations Contributions FB: Project development, data collection, manuscript writing. SF: Manuscript writing/editing. Corresponding author Ethics declarations Funding This paper is not funded. Conflict of interest Fabio Barra declares that he has no conflict of interest. Simone Ferrero declares that he has no conflict of interest. Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors. Rights and permissions About this article Cite this article Barra, F., Ferrero, S. The use of retinoic acid for the treatment of endometriosis. Arch Gynecol Obstet 298, 231–232 (2018). https://doi.org/10.1007/s00404-018-4774-9 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00404-018-4774-9

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Tretinoin Beclin-1 Female Humans Stromal Cells Up-Regulation

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